Squamous Cell Carcinoma of the Upper Aerodigestive Tract Associated With Well-Differentiated Carcinoma of the Thyroid Gland

Pacheco-Ojeda, Luis; Micheau, C; Luboinski, B.; Richard, Jean; Travagli, Jean-Paul; Schwaab, G; Marandas, P.

doi:10.1288/00005537-199104000-00015

Cited by 19 publications

(38 citation statements)

References 4 publications

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“…The rarity of this entity limits our ability to derive statistically significant results. However, it is clear from our data and previously published work 1,6,8,20 that in the presence of incidentally discovered well-differentiated thyroid metastases, a negative physical exam and thyroid ultrasound does not preclude the possibility of a clinically undetected thyroid carcinoma requiring appropriate surgical management. We cannot conclude that all patients require surgical intervention or conservative management, but we offer a diagnostic algorithm (Fig.…”

Section: 1011mentioning

confidence: 52%

“…1,6 Whereas up to 3% of patients with head and neck cancer may harbor clinically unsuspected papillary or follicular thyroid carcinoma, metastatic thyroid carcinoma as an incidental finding during neck dissection is even less common. 6 Controversy exists as to whether these lesions arise from preexisting benign lateral aberrant thyroid tissue that has undergone malignant transformation or as true metastatic lesions from clinically undiagnosed thyroid carcinoma.…”

Section: 1011mentioning

confidence: 99%

“…1,2 Although these lesions may become clinically significant, they are usually associated with an excellent long-term prognosis, and many head and neck surgeons recommend conservative management including frequent physical examinations and follow-up diagnostic studies. The clinical presentation of a metastatic thyroid lesion in a cervical lymph node is generally pursued more aggressively because these are advanced stage lesions.…”

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confidence: 99%

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Significance and management of thyroid lesions in lymph nodes as an incidental finding during neck dissection

et al. 2001

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Section: 1011mentioning

confidence: 52%

Section: 1011mentioning

confidence: 99%

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confidence: 99%

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Significance and management of thyroid lesions in lymph nodes as an incidental finding during neck dissection

et al. 2001

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“…13 Even if lymph nodes are known to represent the site of various aberrant tissues (eg, salivary glands or nevus cells), in the case of thyroid inclusions, cautious judgment is necessary when considering whether it is aberrant tissue or metastatic disease. Some authors 7 argue that the presence of metastasis should be considered when most of the lymph node is involved or when multiple lymph nodes are affected. This patient refused further evaluation and treatment for this finding.…”

Section: Commentmentioning

confidence: 99%

Importance of Routine Evaluation of the Thyroid Gland Prior to Open Partial Laryngectomy

Farrag

Lin

Cummings

et al. 2006

Arch Otolaryngol Head Neck Surg

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To determine the incidence and presentation of synchronous thyroid lesions in a patient population undergoing open partial laryngectomy (OPL), and to determine whether routine preoperative evaluation of the thyroid gland prior to OPL is useful to identify synchronous thyroid lesions in order to reduce the need for reoperation in this complex patient population.Design: Retrospective medical chart review.Setting: Academic institution.Patients: Sixty-seven consecutive patients with laryngeal tumors who had undergone OPL from 1996 to 2005.Interventions: Charts of 67 consecutive patients with laryngeal tumors who underwent OPL in 1996 to 2005 have been reviewed for synchronous thyroid lesions. For all patients, reports of (1) complete preoperative examination findings, (2) inpatient course, (3) postoperative follow-up, and (4) postoperative final histopathologic findings were reviewed. For patients with synchronous thyroid lesions, reports of (1) thyroid evaluation and imaging and (2) preoperative (fine-needle aspiration), (3) intraoperative (frozen section), and (4) postoperative (final) histopathologic results for the thyroid lesions were reviewed.Main Outcome Measures: Incidence of synchronous thyroid lesions and laryngeal cancer in patients undergoing OPL.Results: Eight (11.9%) of 67 (95% confidence interval, 5.3%-22.2%) patients with laryngeal tumors who underwent OPL had evidence of synchronous thyroid lesions. All 8 patients had squamous cell carcinoma of the lar-

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“…In addition, the wishes of the patient should be considered. A conservative approach has been suggested for differentiated thyroid cancers [21, 38] and it is likely that the upper aero-digestive tract cancer rather than the thyroid malignancy influences prognosis [39]. Information on long term follow-up is, however, lacking.…”

Section: Managementmentioning

confidence: 99%

Incidental findings of thyroid tissue in cervical lymph nodes: old controversy not yet resolved?

Triantafyllou

Williams

Angelos

et al. 2015

Eur Arch Otorhinolaryngol

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The clinical significance of papillary or follicular thyroid tissue incidentally discovered in cervical lymph nodes during pathological assessment of neck dissections for non-thyroid cancers of the upper aero-digestive tract is critically reviewed. Special emphasis is given to controversies over normal-looking, nodal, thyroid follicles. Arguments for and against the benign nature of these follicles are considered together with processes that could be involved in their formation. The admittedly limited evidence suggests that benign, thyroid follicular inclusions rarely occur in cervical lymph nodes. Histological criteria that could be helpful in recognising the inclusions, which include assessing their extent in conjunction with the size of the node, are discussed. Finally, an algorithm based on collaboration between specialists, correlating histological findings with imaging and loco-regional control of the upper aero-digestive tract cancer, is suggested for the management of patients with incidentally discovered, nodal thyroid tissue.

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Squamous Cell Carcinoma of the Upper Aerodigestive Tract Associated With Well-Differentiated Carcinoma of the Thyroid Gland

Cited by 19 publications

References 4 publications

Significance and management of thyroid lesions in lymph nodes as an incidental finding during neck dissection

Significance and management of thyroid lesions in lymph nodes as an incidental finding during neck dissection

Importance of Routine Evaluation of the Thyroid Gland Prior to Open Partial Laryngectomy

Incidental findings of thyroid tissue in cervical lymph nodes: old controversy not yet resolved?

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