Squamous cell carcinoma of the paranasal sinuses: The cleveland clinic experience 1977–1986

Abstract

Fifty-four of 103 malignancies of the paranasal sinuses treated at the Cleveland Clinic Foundation between 1977 and 1986 were squamous cell carcinomas. Six arose from the ethmoid sinus and 48 from the maxillary sinus. Of the maxillary sinus patients, 11 presented with T1 or T2 lesions, 20 with T3, 16 with T4, and 7 of these had nodal disease. Treatment was surgery and/or radiation therapy. There was local recurrence in 25 of 48 maxillary sinus patients and in 1 of 6 ethmoid patients. Overall 5-year survival was 38.2% in the maxillary sinus group: T1, 100.0%; T2, 85.7%; T3, 31.8%; and T4, 6.7%. Three of six patients with ethmoid tumors were cured. There was a statistical trend for better prognosis in those patients presenting with ethmoid primaries, with early lesions, treated with both radiation and surgery, and with history of inverting papilloma. There were complications of treatment in 10 patients, four of which resulted in death. Local control was the major problem for these patients; therefore, early detection and aggressive local treatment are desirable.

Flow Cytometry and Squamous Cell Carcinoma of the Maxillary Sinus: A Possible Prognostic Indicator for Multimodality Intervention

“…Survival of advanced lesions (T3 and T4) was 13/21 (61.2%), comparable to previous studies [1, 17, 18]. Flow cytometry demonstrated a 25% aneuploid rate and survival was significantly related to aneuploid flow cytometry (p < 0.01).…”

“…In addition, the biological aggressiveness of these tumors is difficult to predict. Currently the best indicator of patient survival is the initial stage of disease based on the primary tumor [1]. As studies of biological growth evolve, the choice of therapy will eventually depend on the results of an array of studies in lieu of initial tumor presentation.…”

Impact of intra-arterial chemotherapy including internal carotid artery for advanced paranasal sinus cancers involving the skull base

“…Concerning the surgical treatment for resectable T4 disease, the 5-year survival rate was reported to be 7–28% ( Lavertu et al , 1989 ; Carinci et al , 1997 ; Myers et al , 2002 ). For anterior skull base invasion cases including orbital apex invasions, the orbital contents could not be preserved in almost all cases ( Nibu et al , 2002 ).…”

Skull Base Inverted Papilloma: A Comprehensive Review

“…Treatments may include medical intervention, radiation therapy, surgical intervention, or a combination thereof. Early detection and aggressive local treatment are desirable [332]. …”