Squamous cell carcinoma of the anterior tongue: is tumour thickness an indicator for cervical metastasis?

Loganathan, P.; Sayan, A.; Hsu, Derek; Paraneetharan, S.; Ilankovan, V.

doi:10.1016/j.ijom.2016.11.003

Cited by 20 publications

(28 citation statements)

References 29 publications

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“…In several studies, preference for males varied among 48% and 86.4% [18][19][20][21][22][23] and the male frequency we found (53.3%) is within the above-mentioned range. In the literature, mean age is widely variable, it was from 64.3 to 47.5 years, 18,[21][22][23][24] and in our study, it was slightly lower (63.9 years).…”

Section: Agesupporting

confidence: 82%

“…As it was with WDSCCs, the proportion of low risk affected patients (non-drinkers nonsmokers) was high (52.9%). Opposed to data from previously reported studies, 18,22,23,24 41.2% of the sample were PDSCCs and 57.1% of them were males with a mean age of 67.3 years. As it was detected in the MDSCCs group, an unexpectedly high rate of patients harbored BTSCCs (42.8%).…”

Section: Tnm Classificationcontrasting

confidence: 60%

“…Our results are only similar to those from the Ramdass et al study, 21 but completely different to those found in other studies showing that the WD type was the most common followed by the moderately differentiated type. 18,22,23,24 It is interesting to note, that in this study, a high proportion of low risk patients developed SCCT. This data does not agree with previous studies showing that high risk patients comprise the high proportion of the analyzed samples.…”

Section: Microscopic Differentiationmentioning

confidence: 54%

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Squamous cell carcinoma of the tongue in patients older than 45 years

et al. 2018

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This study aims to evaluate the clinicopathological features, TNM status, AJCC staging and behavior of squamous cell carcinoma of the tongue (SCCT) in patients older than 45 years. The files of the Department of Pathology of the Hospital General de México were reviewed and all cases of SCCT in patients older than 45 years were selected. Clinicopathological features, treatment, follow-up, microscopic diagnosis, and IJCC and TNM staging were retrieved. Complete data from 60 cases were evaluated. They were more common in males (mean age = 63.9 years). Unexpectedly a high rate of tumors (38.3%) were in the base of the tongue (BT). Moderately and poorly differentiated SCCT were the most common. 16.7% presented lymph node invasion, 15% were recurrent tumors and BT carcinomas recurred more frequently. A high rate (81.7%) were stage II and 48.3% were low-risk patients. SCCTs in the studied population displayed different clinico-pathological and behavioral features compared with worldwide data. Our results suggest that BT tumors should be treated more aggressively than those in the mobile tongue. BT located tumors were more frequent than previously published. Additional frequency studies will define outcomes in age cohorts with a consensus cutoff for young and elderly populations. More population-based studies should be performed in Latin American regions to acquire accurate data on SCC incidence in elder subpopulations and to identify precisely the etiological factors in these patients.

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Section: Agesupporting

confidence: 82%

Section: Tnm Classificationcontrasting

confidence: 60%

Section: Microscopic Differentiationmentioning

confidence: 54%

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Squamous cell carcinoma of the tongue in patients older than 45 years

et al. 2018

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“…According to Loganathan et al (2017), an approximate number of 500,000 cases of oral cancer occur, every year, around the globe. The tobacco use and HPV infection were related as main causes of carcinoma development in the oral area (KAMINAGAKURA et al, 2016;ACHARYA et al, 2016;LOGANATHAN et al, 2017;HASHIBE;STURGIS, 2013). The tongue is the deadliest site in the mouth (RODRIGUES et al, 2014) with a high incidence of relapse due to lymphatic spread (LOGANATHAN et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…Acharya et al (2016) stated that carcinoma is the eight most common malign neoplasm in the World. According to Loganathan et al (2017), tongue malignancies account for 90% of carcinomas in the oral cavity.…”

Section: Introductionmentioning

confidence: 99%

The Use of the Papanicolaou Stain to Routine Histological Examination: Teaching the Basic Microscopy of Squamous Cell Carcinoma

Mainenti¹

2018

Rev Int Est Exp

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Introduction: The understanding of microscopy classes is imperative to the student in human pathology. Objective: To prepare the student to observe and understand, through tinctorial recognition, the main histologic features of Papanicolaou-stained well-differentiated carcinomas. Methods: A selected case of a well-differentiated carcinoma of the tongue was used for a Papanicolaou stain. Results: The Papanicolaou-stained slides showed, basically, basal cells in a faint to a dark blue color. The stratum spinosum stained light pink to a faint blue-green and the keratin layer and the keratin pearls stained bright orange. The connective tissue stained light green. Conclusion: The use of Papanicolaou stain was found very convenient as the beginner in histopathology can perform a ready identification of the well-differentiated squamous cell carcinoma aspects.

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Occult metastasis is no burden factor in oral squamous cell carcinoma patients when adhering to a standardized approach in neck dissection

Struckmeier,

Buchbender,

Moest

et al. 2024

Clin Oral Invest

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Objectives Management of the neck in patients with oral squamous cell carcinoma (OSCC) is pivotal to oncologic control and survival. However, there is controversy regarding necessity of neck dissection (ND) in patients with clinically node-negative neck. We aimed to assess risk factors for occult metastasis and to explore whether the presence of occult lymph node metastases (LNMs) has an impact on recurrence and survival. Material and methods A retrospective cohort study was performed including patients with primary OSCC who underwent radical tumor resection and ND in a high-volume center adhering to the prevailing German guideline. The ND was performed according to a standardized approach. Results Four hundred twenty-one patients with primary surgically treated OSCC were included. The incidence of occult metastasis was 14.49%. A pathological T stage > 1 (multivariate analysis, odds ratio (OR) 3.958, p = 0.042) and the presence of extranodal extension in LNMs (multivariate analysis, OR 0.287, p = 0.020) were identified as independent risk factors for occult metastasis. When comparing patients with and without occult metastasis, there were no significant differences in terms of progression-free survival (log-rank, p = 0.297) and overall survival (log-rank, p = 0.320). There were no cases of ipsilateral neck recurrence. One patient developed contralateral neck metastasis; however, he initially presented with a unilateral pT1 pN0 tumor. Conclusions Overall, our findings suggest that conducting a standardized approach in ND should be applied in terms of management of the neck in order to maintain survival rates and to prevent neck recurrence in OSCC patients. Clinical relevance. None of the risk factors for occult metastasis can be reliably assessed preoperatively. Although elective ND does not guarantee the complete prevention of neck recurrence, it increases the likelihood of either timely removal of micrometastases or strengthens the justification for adjuvant therapy. Consequently, this approach leads to improvements in clinical outcomes.

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Squamous cell carcinoma of the anterior tongue: is tumour thickness an indicator for cervical metastasis?

Cited by 20 publications

References 29 publications

Squamous cell carcinoma of the tongue in patients older than 45 years

Squamous cell carcinoma of the tongue in patients older than 45 years

The Use of the Papanicolaou Stain to Routine Histological Examination: Teaching the Basic Microscopy of Squamous Cell Carcinoma

Occult metastasis is no burden factor in oral squamous cell carcinoma patients when adhering to a standardized approach in neck dissection

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