Squamous cell carcinoma of cervix origin with rare metastasis to the colon

Abstract

We discuss the rare case of a 47-year-old female with a history of squamous cell carcinoma (SCC) in situ of the cervix, who presents with a bowel obstruction secondary to a sigmoid colon mass confirmed to be SCC of cervical origin. SCC is one of the rare malignancies of the gastrointestinal tract, and may occur as either a primary or secondary lesion. Metastasis from the cervix to the gastrointestinal tract is a rare occurrence, and has only been described in a handful of case reports. The treatment for colonic metastatic tumor arising from cervical SCC remains controversial. Surgery and debulking are the primary treatment modalities, while the role for radiotherapy and chemotherapy remain ambiguous. Further study is required to compare the efficacy of different treatment regimens.

Sigmoid colonic metastasis from a squamous cell carcinoma of the cervix: A rare case report with literature review

“…In the past 3 decades, only 10 cases of metastatic carcinoma from the cervix to the colon have been documented in the literature. [3][4][5][6][7][8][9][10][11][12] Clinicopathological features of the published cases were listed in Table 1. The median age is 51 years in the patients, which ranged from 37 to 62 years.…”

“…Gastrointestinal metastasis from the cervical SCC is an extremely rare occurrence and only a handful of case reports were described until now. In the past 3 decades, only 10 cases of metastatic carcinoma from the cervix to the colon have been published in the literature to date [3][4][5][6][7][8][9][10][11][12] (Table 1). Physicians should be pay more attention this rare metastatic locations of cervical SCC to the sigmoid colon for appropriate diagnosis and treatment of these patients.…”

A case report of an unusual caecal metastatic location of a primary cervical squamous cell carcinoma

“…The remaining 10% of tumors consist of SCC, neuroendocrine tumors, undifferentiated carcinomas and lymphomas [ 4 ]. The primary tumors known to metastasize to the colon include the breast, lung, kidney, ovary, and malignant melanomas [ 5 ]. The literature regarding these tumors is limited, with most articles being solitary case reports.…”

“…Moreover, with the history of SCC of the cervix, the most likely diagnosis was a metastasis of cervical cancer that was confirmed after histopathologic analysis. As a secondary tumor, it arises through metastasis, either by one of these four methods: transperitoneal, hematogenous, lymphatic or transluminal [ 5 ].…”

“…The prognosis of the disease is poor with the overall survival is less than a year [ 1 , 2 , 5 ]. Early detection with prompt intervention is the key factor required in the successful management of these tumors and to improve the overall survival of the patient.…”