Squamous cell carcinoma, malignant melanoma and malignant fibrous histiocytoma arising in burn scars

Alconchel, M.D.; Olivares, C. Mayer; Álvarez, Ramiro

doi:10.1046/j.1365-2133.1997.19552041.x

Cited by 50 publications

(38 citation statements)

References 21 publications

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“…As with burn scar cancers, tumours often start at an ulcer margin and only one portion of the ulcer may undergo malignant change, whilst the rest remains a non-healing inflamed area. [18][19][20] Therefore, it is often essential to perform multiple biopsies to avoid missing occult malignancy. In addition, regional lymph node examination is important because if lymphadenopathy is detected it may warrant a fine needle aspiration or lymph node biopsy.…”

Section: Do Eb Patients Have An Increased Risk Of Extracutaneous Malimentioning

confidence: 99%

Epidermolysis bullosa and cancer

Mallipeddi

2002

Clinical and Experimental Dermatology

134

105

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Epidermolysis bullosa (EB) encompasses a group of inherited blistering skin disorders classified into three main subtypes of simplex, junctional and dystrophic. In recent years there have been substantial advances in our understanding of the molecular basis of these conditions and in the management of such patients. In spite of this progress, squamous cell carcinoma (SCC) is still a major cause of morbidity and mortality, particularly in Hallopeau--Siemens recessive dystrophic EB. The reason why dystrophic EB patients readily develop SCC with such a poor prognosis remains a mystery. This article reviews the epidemiology of cancer in inherited EB and also discusses the clinical features, histological assessment and treatment options of SCC in EB.

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Section: Do Eb Patients Have An Increased Risk Of Extracutaneous Malimentioning

confidence: 99%

Epidermolysis bullosa and cancer

Mallipeddi

2002

Clinical and Experimental Dermatology

134

105

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“…By reviewing the 18 previously documented cases (Table I), we identified that the patient age range was 32–94 years and only 6 cases occurred in individuals aged ≤55 years (2,7,8,12). No predominant gender predilection has been noted for SMT variants.…”

Section: Discussionmentioning

confidence: 99%

An uncommon malignant cutaneous squamomelanocytic tumor

Wang¹,

Zhang²,

Su³

et al. 2013

Experimental and Therapeutic Medicine

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The intermingling of two malignant neoplasms within the same cutaneous tumor is rare. No consensus has been reached for a clear definition and categorization. In the current study, we describe a cutaneous neoplasm; a squamomelanocytic tumor (SMT) with histological features combining those of a squamous cell carcinoma (SCC) and a malignant melanoma (MM). This is the second report of an oculocutaneous SMT, and concerns a subject with a 20-year history of solar lentigo coexisting with solar keratosis in the primary lesion. This type of tumor is quite rare, with a distinct cytological architecture and immunohistochemical features, and the differential diagnosis of SMT may be considered. However, the histogenesis, biological behavior and malignant potential of SMTs remain a matter of speculation. With regard to the treatment, complete surgical resection and close follow-up are recommended.

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“…Double tumors comprising SCC and BCC (2%) and SCC with melanoma[2] (1%) have also been reported. A rare report of three malignancies developing in the same patient[3] has been described. Literature reports only two cases of epithelioid sarcoma in a burn scar[4] and the present case is the first case report of epithelioid sarcoma along with SCC in a burn scar.…”

Section: Discussionmentioning

confidence: 99%