Squamous Cell Carcinoma in Perineal Inflammatory Disease

Gur, Eyal; Neligan, Peter C.; Shafir, Raphael; Reznick, Richard K.; Cohen, M.; Shpitzer, Thomas

doi:10.1097/00000637-199706000-00016

Cited by 42 publications

(24 citation statements)

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“…and an additionally 68 such cases have been reported in the world literature [83][84][85][86][87][88] .…”

Section: Bascom Techniquementioning

confidence: 99%

“…[90] • The average age of presentation is 49 with an average duration of pilonidal disease of 23 years (philipshen et al, 1981). [91] The process of malignant degeneration is similar in pilonidal squamous-cell carcinomas and other chronically inflamed wounds, such as burns, osteomyelitis, scars, skin ulcers and fistulas [92,83,84] Similar to other chronic ulcerative and scarifying cutaneous disorders, it is believed that the development of tumours due to pilonidal sinus is caused by the release of free oxygen radicals by activated inflammatory cells, inducing genetic damage and neoplastic transformation. [90] .Additionally, the normal repair DNA mechanism is impaired in chronic inflammation and predisposes patients to malignancy.…”

Section: Bascom Techniquementioning

confidence: 99%

See 1 more Smart Citation

Pilonidal Disease- Review Article

Singh¹,

Agrawal²,

Singh³

et al. 2017

AIMDR

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Pilonidal disease is a very common anorectal problem that most often arises in the hair follicles of the natal cleft of the sacrococcygeal area. Successful management depends on adherence to well-described surgical principles based on knowledge of pathogenesis and the patient's presentation. Considerable morbidity from prolonged wound Care can be avoided in these typically healthy patients when their disease is cured at initial presentation.

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“…and an additionally 68 such cases have been reported in the world literature [83][84][85][86][87][88] .…”

Section: Bascom Techniquementioning

confidence: 99%

Section: Bascom Techniquementioning

confidence: 99%

Pilonidal Disease- Review Article

Singh¹,

Agrawal²,

Singh³

et al. 2017

AIMDR

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“…The role of HPV in verrucous carcinoma is likely but has to be demonstrated more specifically to determine whether HPV presence is a coincidence or a cofactor in carcinogenesis [16]. Generally, it is believed that malignant transformation is caused by the release of free oxygen radicals by activated inflammatory cells, inducing genetic damage and neoplastic transformation [17,18]. The literature regarding pilonidal sinus verrucous carcinoma is comprised of reports containing very small number of cases with insufficient results.…”

Section: Discussionmentioning

confidence: 99%

Verrucous carcinoma (Buschke–Lowenstein) arising in a sacrococcygeal pilonidal sinus tract: report of a case

Menteş

Akbulut

Bağcı

2007

Langenbecks Arch Surg

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“…After an extensive literature survey, an additional 12 cases could be added. [3][4][5][6][7][8][9][10][11][12] …”

Section: Literature Reviewmentioning

confidence: 99%

“…Until now, only 56 such cases have been reported in the international literature. [2][3][4][5][6][7][8][9][10][11][12] Herein, we report three new cases treated in the Departments of Surgical Oncology and Radiotherapy at the University Hospital in Herakleion, Greece, and at The Netherlands Cancer Institute in Amsterdam during the last 5 years. In a collective review, the data of these 59 cases were analyzed, especially regarding treatment and outcome, to form treatment recommendations with the aim of reducing the recurrence rate and improving survival.…”

mentioning

confidence: 99%