Squamous Cell Carcinoma in a Capybara (&lt;i&gt;Hydrochoerus            hydrochaeris&lt;/i&gt;)

Hamano, Takahisa; Terasawa, Fumio; Tachikawa, Yoshiharu; Murai, Atsuko; Mori, Takashi; El‐Dakhly, Khaled Mohamed; Sakai, Hiroki; Yanai, Tokuma

doi:10.1292/jvms.13-0395

Cited by 14 publications

(16 citation statements)

References 14 publications

(28 reference statements)

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“…A few reports of postmortem cross‐sectional imaging for the purpose of cause of death determination or for final diagnoses and not necessarily for forensic purposes are found in the veterinary literature . Postmortem CT with guided biopsy was investigated in a group of 11 Bernese mountain dogs with suspected histiocytic sarcoma and with postmortem intervals in this group ranging from 7 h to 12 days .…”

Section: Use Of Forensic Radiology and Imaging In Veterinary Medicinementioning

confidence: 99%

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Forensic Radiology and Imaging for Veterinary Radiologists

Watson

Heng

2017

Vet Radiology Ultrasound

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Imaging studies are often of evidentiary value in medicolegal investigations involving animals and the role of the veterinary radiologist is to interpret those images for courts as an expert or opinion witness. With progressing interest in prosecuting animal crimes and strengthening of penalties for crimes against animals, the participation of veterinary radiologists in medicolegal investigations is expected to increase. Veterinary radiologists who are aware of radiographic and imaging signs that result in animal suffering, abuse, or neglect; knowledgeable in ways radiology and imaging may support cause of death determinations; conversant in postmortem imaging; comfortable discussing mechanisms and timing of blunt or sharp force and projectile trauma in imaging; and prepared to identify mimics of abuse can assist court participants in understanding imaging evidence. The goal of this commentary review is to familiarize veterinary radiologists with the forensic radiology and imaging literature and with the advantages and disadvantages of various imaging modalities utilized in forensic investigations. Another goal is to provide background information for future research studies in veterinary forensic radiology and imaging.

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Section: Use Of Forensic Radiology and Imaging In Veterinary Medicinementioning

confidence: 99%

“…A diagnosis of histiocytic sarcoma was confirmed in 10 of 11 dogs by PMCT‐guided biopsy. Two additional reports involve postmortem imaging of exotic animals to provide final diagnoses …”

Section: Use Of Forensic Radiology and Imaging In Veterinary Medicinementioning

confidence: 99%

Forensic Radiology and Imaging for Veterinary Radiologists

Watson

Heng

2017

Vet Radiology Ultrasound

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“…Recently, the use of advanced imaging diagnostic methods in veterinary medicine has been recommended [ 6 , 7 ] and considered [ 6 , 8 – 10 ].…”

Section: Introductionmentioning

confidence: 99%

Post mortem computed tomography and core needle biopsy in comparison to autopsy in eleven bernese mountain dogs with histiocytic sarcoma

et al. 2015

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BackgroundBernese mountain dogs are reported to have a shorter life expectancy than other breeds. A major reason for this has been assigned to a high tumour prevalence, especially of histiocytic sarcoma. The efforts made by the breeding clubs to improve the longevity with the help of genetic tests and breeding value estimations are impeded by insufficiently reliable diagnoses regarding the cause of death. The current standard for post mortem examination in animals is performance of an autopsy. In human forensic medicine, imaging modalities, such as computed tomography and magnetic resonance imaging, are used with increasing frequency as a complement to autopsy. The present study investigates, whether post mortem computed tomography in combination with core needle biopsy is able to provide a definitive diagnosis of histiocytic sarcoma. For this purpose we have analysed the results of post mortem computed tomography and core needle biopsy in eleven Bernese mountain dogs. In the subsequent autopsy, every dog had a definitive diagnosis of histiocytic sarcoma, based on immunohistochemistry.ResultsComputed tomography revealed space-occupying lesions in all dogs. Lesion detection by post mortem computed tomography was similar to lesion detection in autopsy for lung tissue (9 cases in computed tomography / 8 cases in autopsy), thoracic lymph nodes (9/8), spleen (6/7), kidney (2/2) and bone (3/3). Hepatic nodules, however, were difficult to detect with our scanning protocol (2/7). Histology of the core needle biopsies provided definitive diagnoses of histiocytic sarcoma in ten dogs, including confirmation by immunohistochemistry in six dogs. The biopsy samples of the remaining dog did not contain any identifiable neoplastic cells. Autolysis was the main reason for uncertain histological diagnoses.ConclusionsPost mortem computed tomography is a fast and effective method for the detection of lesions suspicious for histiocytic sarcoma in pulmonary, thoracic lymphatic, splenic, osseous and renal tissue. Optimization of the procedure regarding the scanning protocol and tissue sample size and number will improve the accuracy of the method.

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“…For example, a cutaneous T cell lymphoma in an antelope ( Addax nasomaculatus ) with metastatic spread to multiple lymph nodes [24], an intestinal lymphosarcoma in an African black-footed penguin ( Spheniscus demersus ) with metastatic spread to the liver and kidneys [50], and a uterine T-cell lymphoma in an Atlantic bottle-nosed dolphin ( Tursiops truncates ) with metastatic spread to the lung, pituitary gland and peritoneum [35], all showed strong immunohistochemical staining for CD3 but not CD79a, confirming the lymphocytes to be of T cell origin (CD3 and CD79a are used as immunohistochemical markers of T and B-cell leukaemias/lymphomas in humans, respectively). In another case report, a cutaneous squamous cell carcinoma in a capybara ( Hydrochoerus hydrochaeris ) with regional lymph node metastases showed positive immunohistochemical staining for cytokeratin AE1/AE3, confirming the cell origin as being epithelial [39]. In addition, a pulmonary adenocarcinoma in a llama ( Lama glama ) with liver and bone metastases showed positive immunohistochemical staining for pan-cytokeratin, cytokeratin 7, and cytokeratin 5/6 antibodies and negative staining for vimentin and cytokeratins 8/18 and 20 antibodies, consistent with bronchioloalveolar carcinoma in humans [28].…”

Section: Occurrences Of Spontaneous Metastasis In Non-laboratory Animalsmentioning

confidence: 99%

Metastasis in the wild: investigating metastasis in non-laboratory animals

Abu-Helil

Weyden

2019

Clin Exp Metastasis

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Humans are not the only species to spontaneously develop metastatic cancer as cases of metastasis have been reported in a wide range of animals, including dinosaurs. Mouse models have been an invaluable tool in experimental and clinical metastasis research, with the use of genetically-engineered mouse models that spontaneously develop metastasis or ectopic/ orthotopic transplantation of tumour cells to wildtype or immunodeficient mice being responsible for many key advances in our understanding of metastasis. However, are there other species that can also be relevant models? Similarities to humans in terms of environmental exposures, lifespan , genetics, histopathology and available therapeutics are all factors that can be considered when looking at species other than the laboratory mouse. This review will explore the occurrence of metastasis in multiple species from a variety of domestic, captive and free-living veterinary cases to assist in identifying potential alternative experimental and clinical research models relevant to humans.

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Squamous Cell Carcinoma in a Capybara (<i>Hydrochoerus hydrochaeris</i>)

Cited by 14 publications

References 14 publications

Forensic Radiology and Imaging for Veterinary Radiologists

Forensic Radiology and Imaging for Veterinary Radiologists

Post mortem computed tomography and core needle biopsy in comparison to autopsy in eleven bernese mountain dogs with histiocytic sarcoma

Metastasis in the wild: investigating metastasis in non-laboratory animals

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