Squamous cell carcinoma in a giant bladder diveticulum

Abiad, Yassine El; Bakloul, Fouad

doi:10.11604/pamj.2015.20.378.6765

Cited by 3 publications

(1 citation statement)

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“…Urinary stasis in BD might be associated with chronic infection and inflammation that lead to stone formation, dysplasia development, squamous cell metaplasia and leukoplakia, which increase the possibility of intradiverticular neoplasm development [24]. In addition, types of carcinoma that arise from BD include squamous cell carcinoma [7–8], adenocarcinoma [9], urothelial carcinoma [10], small cell carcinoma [11], and primary osteosarcoma [12]. Among these malignancies, urothelial carcinoma is the most common (78%), followed by squamous cell carcinoma (17%), a combination of transitional and squamous cell types (2%), and adenocarcinoma (2%) [25].…”

Section: Discussionmentioning

confidence: 99%

A population-based cohort study examining the association of documented bladder diverticulum and bladder cancer risk in urology patients

et al. 2019

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ObjectivesStudies have shown a high risk of tumor development within a bladder diverticulum (BD). We were interested in the relationship between BD and the development of bladder cancer. Herein, we attempted to investigate whether there exists an association between documented BD and subsequent risk of bladder cancer.MethodsWe identified 10,662 hospitalized urology patients, including 2,134 documented BD patients (study cohort) and 8,528 non-BD subjects (comparison cohort) from Taiwan’s National Health Insurance database. Only urology patients were enrolled in the study to minimize selection bias. The two cohorts were frequency-matched 1:4 by age, sex and index-year. Patients with less than one year of follow-up were excluded to avoid inverting cause and effect. Risks of developing bladder cancer were estimated using the Cox proportional hazard regression model.ResultsThere was an increased bladder cancer risk in the documented BD patients. The incidence of bladder cancer in documented BD patients was 2.60-fold higher than that in the comparison group, and the overall risk-factor-adjusted hazard ratio was 2.63 (95% CI, 1.74–3.97). Moreover, stratified analysis by sex also showed that documented BD patients were at higher risk of subsequent bladder cancer than the comparison cohort. The effect of BD on the risk of bladder cancer was higher in males than in females and was more profound in patients without comorbidities than in those with comorbidities.ConclusionIn this population-based longitudinal study, urology patients with documented BD might have an elevated risk of subsequent bladder cancer. Based on the limitations of the retrospective study design, further studies are required.

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Section: Discussionmentioning

confidence: 99%

A population-based cohort study examining the association of documented bladder diverticulum and bladder cancer risk in urology patients

et al. 2019

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Diagnosis and management of intradiverticular bladder tumours: A pooled analysis of 498 cases

Katsimperis

Tzelves

Bellos

et al. 2022

Arch Ital Urol Androl

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Objective: Intradiverticular bladder tumors (IDBT) are uncommon clinical entities. We reviewed the literature for clinical presentation, diagnosis and therapeutic options to establish recommendations for diagnostic and therapeutic management. Methods: Bibliographic research was performed using PubMed from database inception until October 15, 2022. A pooled analysis was performed of 498 patients with IDBT presented in the literature. The evaluation included patient sex, age, diagnostic methods, symptoms, localization of the tumor, tumor staging, tumor histopathology, treatment, and the presence of recurrence. To express results, descriptive statistics were used appropriately. Results: The mean age at diagnosis was 64.81 years (range 49 days to 84 years). The ratio between men and women was ≈ 24:1, suggesting a male predominance (85% male, 3.6% female). The most common presenting symptom was gross hematuria (60.88%). Most of the patients had cystoscopy (56.85%) and intravenous or computed tomography urography (52.01%). Regarding tumor staging, most of the patients were diagnosed with pT1 tumors. For the histopathology of IDBT, 87.95% of the specimens were transitional cell carcinomas and in 10.84% there were concomitant CIS. Regarding the treatment, radical cystectomy was chosen in 34.34%, partial cystectomy in 26.66%, diverticulectomy in 15.95% and transurethral resection of bladder tumour (TURBT) in 16.36% of the patients.Conclusions: Most common diagnostic tool for IDBT seems to be cystoscopy followed by computerized tomography urogram. Due to the absence of muscle layer in the diverticulum and the highgrade histology of most of them at diagnosis, cystectomy is the first therapeutic choice. However, for patients that are not considered appropriate candidates or for those presenting with lowgrade and low volume tumors, TURBT is a good option.

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Clinical Presentation, Tumor Characteristics, and Management of Intradiverticular Transitional Cell Carcinoma of the Urinary Bladder: A Systematic Review

Aijaz,

Farooqi Baloch,

Faiz

et al. 2024

Cureus

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Squamous cell carcinoma in a giant bladder diveticulum

Cited by 3 publications

References 0 publications

A population-based cohort study examining the association of documented bladder diverticulum and bladder cancer risk in urology patients

A population-based cohort study examining the association of documented bladder diverticulum and bladder cancer risk in urology patients

Diagnosis and management of intradiverticular bladder tumours: A pooled analysis of 498 cases

Clinical Presentation, Tumor Characteristics, and Management of Intradiverticular Transitional Cell Carcinoma of the Urinary Bladder: A Systematic Review

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