Squamous cell carcinoma arising in plaque-like oral lichen planus: A case report

Prapinjumrune, Chanwit; Chaisuparat, Risa; Kobkan, Thongprasom

doi:10.17219/dmp/70528

Cited by 5 publications

(5 citation statements)

References 20 publications

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“…An atrophic pattern was the most commonly found in Thai patients in this group, followed by ulcerative and reticular patterns, corresponding to a previous study . Interestingly, 1 case with an OLP plaque pattern with negative DIF findings developed oral squamous cell carcinoma (OSCC) after 7 years of follow up . Moreover, a 52‐year‐old woman with histopathology and DIF confirming OLP had a family history of her mother developing OSCC.…”

Section: Discussionsupporting

confidence: 84%

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Correlation of clinicopathological characteristics and direct immunofluorescence studies in oral lichenoid lesion in Thai patients

Tikkhanarak

Wangboo

Sookviboonpol

et al. 2019

J of Invest & Clin Dent

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Aim To investigate the correlation between the clinicopathological characteristics, serum antinuclear antibody (ANA) and direct immunofluorescence (DIF) findings in oral lichen planus (OLP) and oral lichenoid lesion (OLL). Methods Fifty three Thai patients with red and white lesions were divided into 3 groups: 17 cases of OLP, 19 cases of OLL and 17 cases of oral lichenoid drug reaction (OLDR), respectively. The medical records, photographs, histopathological evaluation and laboratory ANA and DIF results were analyzed. Results Atrophic pattern was the most commonly found pattern in the OLDR, OLP and OLL groups. In the OLP group, the DIF interpretation confirmed only 41.2% of cases as OLP, with 23.5% each as lichen planus (LP)/lupus erythematosus (LE) or negative findings. In the OLL group, the most common DIF interpretation (31.6% each) was LP/LE or non‐specific finding. In the OLDR group, DIF interpretation was OLP or LP/LE (23.5% each), with 5.9% each of immune complex‐mediated disease, compatible with OLP, and mixed connective tissue disease. Interestingly, 1 case in the OLDR group demonstrated mild to moderate dysplasia. There were no significant differences in ANA positivity or patterns between the 3 groups. Conclusion An OLP‐like lesion could be diagnosed as OLP, OLP/LE, chronic ulcerative‐like lesion, immune‐mediated disease or dysplasia.

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Section: Discussionsupporting

confidence: 84%

“…case with an OLP plaque pattern with negative DIF findings developed oral squamous cell carcinoma (OSCC) after 7 years of follow up 12. Moreover, a 52-year-old woman with histopathology and DIF confirming OLP had a family history of her mother developing OSCC.…”

mentioning

confidence: 99%

Correlation of clinicopathological characteristics and direct immunofluorescence studies in oral lichenoid lesion in Thai patients

Tikkhanarak

Wangboo

Sookviboonpol

et al. 2019

J of Invest & Clin Dent

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“…The details of this case have been published. 18 In summary, this patient was initially diagnosed with OLP. The DIF result was negative.…”

Section: Resultsmentioning

confidence: 83%

Direct immunofluorescence cannot be used solely to differentiate among oral lichen planus, oral lichenoid lesion, and oral epithelial dysplasia

Korkitpoonpol¹,

Kanjanabuch²

2023

Journal of Dental Sciences

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“…The erosive, ulcerative [ 13 – 15 ], and plaque-type [ 16 , 17 ] OLP have the highest risk of malignant transformation. Sufficient data regarding the risk of malignant transformation of different types of OLRs are not available, but it appears that different types of graft versus host disease and oral lichenoid contact lesions have higher risk of malignant transformation than drug-induced OLRs [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Serum and salivary levels of lactate dehydrogenase in oral squamous cell carcinoma, oral lichen planus and oral lichenoid reaction

et al. 2020

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Background Increased levels of lactate dehydrogenase (LDH) as a tumor marker have been reported in malignant and some premalignant oral lesions such as oral lichen planus (OLP) and oral lichenoid reactions (OLRs). This study aimed to assess the level of total LDH in the saliva and serum of patients with oral squamous cell carcinoma (OSCC), OLP and OLRs. Methods In this case–control study, the participants were divided into four groups (n = 25) of healthy controls, OLP, OLRs, and OSCC. The serum and stimulated/unstimulated salivary levels of LDH were spectrophotometrically measured using standard LDH kits (Pars Azmoun). One-way ANOVA, Chi-square test, Pearson’s correlation test, and receiver operating characteristic (ROC) analysis were applied to analyze the data. Results The serum and salivary levels of LDH in OSCC patients were significantly higher than that the corresponding values in other groups (P = 0.0001). The serum level of LDH in OLR group was significantly higher than that in the control and OLP groups (P = 0.0001), but the difference in salivary level of LDH was not significant. The ROC analysis showed that both the serum and salivary levels of LDH had significant diagnostic ability for detection of OSCC and OLRs. Significant associations were noted between the serum and salivary levels of LDH. Conclusions Patients with OSCC and OLRs had higher serum levels of LDH than OLP and control groups. Further prospective longitudinal studies are required to assess the tissue level of LDH and monitor the transformation of OLRs because they have low rate of malignant transformation compared with other oral premalignant lesions.

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Squamous cell carcinoma arising in plaque-like oral lichen planus: A case report

Cited by 5 publications

References 20 publications

Correlation of clinicopathological characteristics and direct immunofluorescence studies in oral lichenoid lesion in Thai patients

Correlation of clinicopathological characteristics and direct immunofluorescence studies in oral lichenoid lesion in Thai patients

Direct immunofluorescence cannot be used solely to differentiate among oral lichen planus, oral lichenoid lesion, and oral epithelial dysplasia

Serum and salivary levels of lactate dehydrogenase in oral squamous cell carcinoma, oral lichen planus and oral lichenoid reaction

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