Squamous Cell Carcinoma Arising in a Second Branchial Cleft Cyst

Girvigian, M.R.; Rechdouni, Aida K.; Zeger, Gary; Segall, Hervey D.; Rice, Dale H.; Petrovich, Zbigniew

doi:10.1097/01.coc.0000047127.46594.c0

Cited by 36 publications

(24 citation statements)

References 11 publications

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“…Reports indicate a significant incidence of local recurrence, frequent node metastases, and occasionally death due to disease. [33][34][35] The most recent reviews of the subject were those published by Hong and colleagues 35 in 1999 and by Girvigian and colleagues 36 …”

Section: Branchial Cleft Cysts Sinuses and Fistulasmentioning

confidence: 99%

Cysts of the Neck, Unknown Primary Tumor, and Neck Dissection

Luna¹,

Pfaltz²

2009

Diagnostic Surgical Pathology of the Head and Neck

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Section: Branchial Cleft Cysts Sinuses and Fistulasmentioning

confidence: 99%

Cysts of the Neck, Unknown Primary Tumor, and Neck Dissection

Luna¹,

Pfaltz²

2009

Diagnostic Surgical Pathology of the Head and Neck

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“…Due to their shared anatomic region, primary branchial cleft cyst carcinoma needs to be distinguished from cystic cervical metastases arising from occult primary tumors in the upper aerodigestive tract, which have a much higher incidence rate (1,2,5,7,8). The majority of cystic cervical metastases originate from Waldeyer's ring, including the nasopharynx, tonsil and the base of the tongue.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have revealed that most of the so-called primary branchial cleft cyst carcinomas are actually cystic cervical metastases resulting from oropharyngeal carcinoma, most commonly originating in the tonsils in the upper aerodigestive tract (5). To date, there are only approximately 40 cases of primary branchiogenic carcinoma reported in the literature, which were found mostly in men aged 40-60 with the majority of cases involving second branchial cleft cysts (6,7). In terms of primary carcinoma in the first branchial vestigium, to the best of our knowledge, there are only 5 reported cases, all of which occurred in adults (1,8,9).…”

Section: Introductionmentioning

confidence: 99%

Primary branchiogenic carcinoma in the first branchial cleft of a child

Teng

Wang

et al. 2012

Oncology Letters

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Abstract. To our knowledge, no case report of first branchial cleft carcinoma has been described in children. Herein, we report a case of squamous cell carcinoma that developed in the vestigium of the first branchial apparatus in a 10-year-old girl who had suffered from first branchial cleft sinus since childhood. Following a wide surgical excision and neck dissection, the patient has remained in good health for 2.5 years without developing any primary or recurrent tumors locally or elsewhere. Based on this case report, it is significant to check whether a patient has ever suffered from congenital lateral cervical sinus, fistulae or cysts during a history consultation, as this could be employed, in addition to the criteria of Khafif et al, to aid the diagnosis of primary branchiogenic carcinoma.

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“…On the other hand, the histology illustrat ing a transition of the epithelium to the carcinoma is the strongest argument support ing the existence of this clinical unit, which has never been explained in another way [5][6][7].…”

Section: Case Reportmentioning

confidence: 99%

Primary Branchiogenic Carcinoma

Hořáková¹,

Velecký²,

Pažourková³

et al. 2018

Klin Onkol

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SummaryBackground: Primary branchiogenic carcinoma (BC) is an exceptional dia gnostic entity. In most cases, suspicion of BC is confirmed to be a cystic lymph node metastasis of an occult primary tumor. Martin and Khafif therefore established dia gnostic criteria, emphasiz ing above all the importance of a histologically assessed transformation of cystic lin ing epithelium into an invasive squamous cell carcinoma in one pathological lesion after the exclusion of a primary tumor. Case report: We present a case report of an 80-year-old patient who presented for a follow-up for an 8-year history of a benign lateral cervical cyst, which was not surgically treated due to the patient's high risk of complications from general anesthesia. In spite of the risk, the surgery was performed after a sudden clinical progression, and surprisingly, post-operative histology revealed BC. Conslusion: BC is a very rare entity, strictly defined by Martin's and Khafif's criteria. Recently, BCs have been presented in the literature only as unique case reports respond ing as in our patient to the above mentioned criteria, with particular emphasis on the histological aspect, imag ing the cystic lin ing epithelium transform ing into an invasive squamous cell carcinoma in one pathological lesion and a long history without evidence of primary tumor.

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Squamous Cell Carcinoma Arising in a Second Branchial Cleft Cyst

Cited by 36 publications

References 11 publications

Cysts of the Neck, Unknown Primary Tumor, and Neck Dissection

Cysts of the Neck, Unknown Primary Tumor, and Neck Dissection

Primary branchiogenic carcinoma in the first branchial cleft of a child

Primary Branchiogenic Carcinoma

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