Squamous Cell Carcinoma Arising in a Hepatic Forgut Cyst

Lajarte-Thirouard, Anne-Sophie de; Rioux‐Leclercq, Nathalie; Boudjéma, Karim; Gandon, Y.; Ramée, M. P.; Turlin, Bruno

doi:10.1078/0344-0338-00323

Cited by 56 publications

(34 citation statements)

References 11 publications

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“…The clinical course of CHFC is essentially benign, although three patients [13][14][15] have been recently shown to develop squamous cell carcinoma (SCC), suggesting the overall rate of malignancy to be 3%. All patients with CHFC complicated by SCC had huge cysts with an average size of 10.6 cm; this is in sharp contrast to the small size of the benign cysts.…”

Section: Discussionmentioning

confidence: 99%

Ciliated Hepatic Foregut Cyst: An Increasingly Diagnosed Condition

et al. 2008

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Ciliated hepatic foregut cyst is a rare foregut cystic developmental malformation. It presents as a solitary cystic lesion in segment four of the liver. Histologically, it consists of four distinct layers; namely, the inner ciliate columnar epithelium, subepithelial connective tissue, smooth muscle layer, and an outer fibrous layer. Usually asymptomatic and detected incidentally, other modes of presentation can include portal hypertension, obstructive jaundice, and development of malignancy. We present a case of a young asymptomatic woman with a complex cyst in segment four of the liver, who underwent a laparoscopic resection, focusing our discussion on the review of the literature and the diagnostic dilemma encountered in these rare cases.

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Section: Discussionmentioning

confidence: 99%

Ciliated Hepatic Foregut Cyst: An Increasingly Diagnosed Condition

et al. 2008

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“…Indeed, it has never been described in the largest series including one with an extensive literature review [1,11]. To our knowledge, the only three cases of CHFC with squamous metaplasia described so far were always associated with a squamous carcinoma [2,3,12]. This could suggest that squamous metaplasia in CHFC is rare, and that when it appears, it rapidly degenerates into carcinoma.…”

Section: Discussionmentioning

confidence: 85%

“…Ciliated hepatic foregut cysts are usually benign solitary unilocular asymptomatic lesions; however, three cases of malignant transformation have been described. It is interesting to note that these three cases corresponded to a squamous cell carcinoma developed from foci of squamous metaplasia with dysplasia [2,3,12]. In this study, we report the first case of CHFC with extensive squamous metaplasia without dysplasia or carcinoma.…”

Section: Introductionmentioning

confidence: 92%

Ciliated hepatic foregut cyst with extensive squamous metaplasia: report of a case

et al. 2006

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Ciliated hepatic foregut cysts (CHFC) are rare cystic lesions of the liver composed of a ciliated pseudostratified columnar epithelium with mucous cells, connective tissue, and smooth muscles bundles. We report the first case of CHFC with extensive squamous metaplasia without dysplasia or carcinoma. A unilocular, avascular, hypoechoic 60-mm liver lesion located in segment IV was detected by ultrasonography in a 31-year-old woman. The cyst was surgically removed and was lined mainly by a regular squamous epithelium without keratin formation. After extensive sampling, a ciliated pseudostratified columnar epithelium with some alcian blue-positive goblet cells was identified. The lesion was totally examined and there was no epithelial dysplasia or carcinoma. Squamous epithelium is very rare in hepatic foregut cysts and may degenerate into squamous carcinoma. Squamous epithelium is also described in biliary cysts. When squamous epithelium is identified in a liver cyst, an extensive sampling is recommended to identify possible foci of squamous carcinoma and to classify more precisely the histological type of the lesion. Because some cases of squamous carcinoma have been described in CHFC, surgical removal of the lesion may be more appropriate than close follow-up or sclerosing therapy.

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“…Foregut cysts in esophageal, bronchial, and hepatic locations have been found to contain areas of adenocarcinoma. [9][10][11][12] One case of squamous cell metaplasia in a sublingual foregut cyst has been reported as well. 13 To our knowledge, this is the first case of adenocarcinoma arising in a lingual foregut cyst of the oral cavity.…”

Section: Commentmentioning

confidence: 99%