Squamous cell carcinoma arising in an epidermal inclusion cyst

Alkul, Suzanne; Nguyen, Christopher N; Ramani, Nisha S.; Alkul, Mahmud; Orengo, Ida; Shimizu, Ikue; Krishnan, Bhuvaneswari

doi:10.1080/08998280.2022.2077600

Cited by 5 publications

(15 citation statements)

References 17 publications

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“…Histologically, a milium (classified as a small epidermal cyst) or EIC is lined by squamous epithelium, a preserved granular layer, and epidermal-type keratinous material in the lumen [ 1 ]. Multiple malignancies have been reported to arise from EICs, including basal cell carcinoma (BCC), SCC, and Merkel cell carcinoma (MCC) [ 1 ]. The most common is well-differentiated SCC involving the head and neck further supported by a literature review from 1976-2021 demonstrating 56 cases.…”

Section: Discussionmentioning

confidence: 99%

“…Squamous cell carcinoma (SCC) is the second most common cutaneous malignancy that arises from atypical keratinocytes of the epidermis [ 1 ]. Histologically, it can be classified on a spectrum from well to poorly differentiated, can be invasive versus in-situ, and has varying potential for perineural invasion, lymphovascular invasion, and metastasis; however, it is unusual to see cystic structures [ 1 ]. Epidermal inclusion cysts (EIC) and milia are typically clinically evident as round structures filled with keratin [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…Histologically, it can be classified on a spectrum from well to poorly differentiated, can be invasive versus in-situ, and has varying potential for perineural invasion, lymphovascular invasion, and metastasis; however, it is unusual to see cystic structures [ 1 ]. Epidermal inclusion cysts (EIC) and milia are typically clinically evident as round structures filled with keratin [ 1 ]. Histologically, they are lined by squamous epithelium, a preserved granular layer, and keratinous material in the lumen [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…Epidermal inclusion cysts (EIC) and milia are typically clinically evident as round structures filled with keratin [ 1 ]. Histologically, they are lined by squamous epithelium, a preserved granular layer, and keratinous material in the lumen [ 1 ]. Rarely, these benign neoplasms can transform into a malignancy [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…Histologically, they are lined by squamous epithelium, a preserved granular layer, and keratinous material in the lumen [ 1 ]. Rarely, these benign neoplasms can transform into a malignancy [ 1 ]. We report a case of biopsy-proven, moderately well-differentiated invasive SCC treated with Mohs surgery that showed benign appearing milia/cyst-like structures in the margins.…”

Section: Introductionmentioning

confidence: 99%

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Squamous Cell Carcinoma With Unusual Benign-Appearing Cystic Features on Histology

Asad¹,

Alkul²,

Shimizu³

et al. 2023

Cureus

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Squamous cell carcinoma (SCC) is a malignancy that arises from keratinocytes of the epidermis. Cystic variants of several types of cutaneous neoplasms have been rarely described in the literature. We report a case of biopsy-proven, well-differentiated invasive SCC treated with Mohs surgery. On frozen sections, the pathology slides showed benign-appearing cystic structures in the margins that persisted after it had appeared that the original malignancy had been cleared. After taking another Mohs stage due to clinical suspicion, additional SCC was found and was subsequently cleared after two more Mohs stages. To the best of our knowledge, this is the first report to histologically demonstrate biopsy-proven invasive SCC with benign-appearing cystic structures on frozen sections.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Squamous Cell Carcinoma With Unusual Benign-Appearing Cystic Features on Histology

Asad¹,

Alkul²,

Shimizu³

et al. 2023

Cureus

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Epidermoid cyst beneath the scar after total knee arthroplasty: a case report

Ying

Luo

2023

Journal of Surgical Case Reports

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The epidermal cysts are benign cysts most commonly found in the head, neck and trunk. An epidermal cyst of the knee is an unusual complication developed after total knee arthroplasty. Here, we present a case of an 83-year-old man with a palpable mass in the left knee located beneath the scar, 3 years after total knee arthroplasty. The patient underwent complete surgical excision of the mass. Histological analysis revealed an epidermoid cyst.

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Diagnosis and therapy of giant epidermoid double cysts with infection on the buttock: A case report and literature review

Wu,

Wang,

Jiang

et al. 2024

Medicine

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Rationale: Epidermoid cyst (EC) is a common clinical condition and it can be filled with keratinized material. EC often represents painless, slow progressive growth, and single cyst. The cyst is usually 1 to 5 cm in size. Giant epidermoid cysts on the buttock area are extremely rare, and reports of giant epidermoid double cysts on the buttock are even rarer. Patient concerns: This paper reports a patient with a painless mass was on the left buttock. Diagnosis: A giant epidermoid double cysts with infection in a left buttock paranal location. Interventions: The mass was surgically removed. Outcomes: The patient recovered well after surgical treatment and currently has no recurrence. Conclusion: For patients with EC, MRI is recommended as a routine examination before surgery in order to detect the variation and extent of the cyst early. This lays a foundation for the complete resection of the lesion during the operation. The review of relevant literature will hopefully be helpful to clinicians.

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Squamous cell carcinoma arising in an epidermal inclusion cyst

Cited by 5 publications

References 17 publications

Squamous Cell Carcinoma With Unusual Benign-Appearing Cystic Features on Histology

Squamous Cell Carcinoma With Unusual Benign-Appearing Cystic Features on Histology

Epidermoid cyst beneath the scar after total knee arthroplasty: a case report

Diagnosis and therapy of giant epidermoid double cysts with infection on the buttock: A case report and literature review

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