Squamous cell carcinoma arising in an ovarian mature cystic teratoma complicating pregnancy

Yun, Nae-Ri; Jung-Woo, Park; Hyun, Myung-Soo; Park, Jeehyun; Choi, Sangdun; Song, Eun Seop

doi:10.5468/ogs.2013.56.2.121

Cited by 11 publications

(2 citation statements)

References 14 publications

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“…Our study suggests that for SCC transformation in MCTO, it is safe and feasible to perform fertility-sparing surgery in patients younger than 45 years of age old with stage IA/IC. There are cases of successful pregnancies after fertility-sparing surgery [ 57 , 74 , 83 ].…”

Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a systematic review

Zhang

et al. 2019

BMC Cancer

134

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Background0.17–2% of mature cystic teratoma of the ovary (MCTO) undergo malignant transformation, of which 80% are squamous cell carcinoma (SCC) transformation in MCTO. We aim to investigate the clinical characteristics and treatment of SCC transformation in MCTOMethodsWe systematically searched PubMed database and individual patient data about SCC transformation in MCTO were extracted. The published cases were combined with 6 cases of SCC transformation in MCTO from Qilu Hospital, Shandong University.ResultsThe incidence of SCC transformation in MCTO was 0.3%. A total of 435 cases of SCC transformation in MCTO were enrolled in the analysis. The mean age of diagnosis was 53.5 (range 19–87) years old. The most common clinical manifestations were abdominal pain (47.3%) and abdominal mass (26.0%). StageI,II, III and IV accounted for 50.0, 18.8, 26.8 and 4.4% of all cases, respectively. Patients with stage I had significantly better prognosis than stage II, III and IV patients (P < 0.01). Hysterectomy can improve overall survival (P < 0.01). For patients younger than 45 years old with stageIA orIC, there was no difference in mortality between fertility-sparing and radical surgery (P = 1.00). Adjuvant chemotherapy can improve survival in patients with advanced stage (P = 0.02), and chemotherapy with platinum was related to better prognosis (P = 0.02).ConclusionSCC transformation in MCTO is a rare malignancy mainly occurs in older age. FIGO stage is an independent prognostic factor. Hysterectomy and platinum-based chemotherapy are associated with better survival. Fertility-sparing surgery is feasible for young patients with early stage.Electronic supplementary materialThe online version of this article (10.1186/s12885-019-5393-y) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a systematic review

Zhang

et al. 2019

BMC Cancer

134

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“…Granulomatous peritonitis happened in a 27-year-old primigravida female postoperatively following surgical removal of a ruptured dermoid cyst in the second trimester of pregnancy (11); another rare but ominous complication of mature cystic teratomas is malignant transformation. A case of squamous cell carcinoma developed from a dermoid cyst during pregnancy is reported (12).…”

Section: Discussionmentioning

confidence: 99%

Surgical Management of an Ovarian Bilateral Multiple Dermoid Cyst During Pregnancy: A Case Report Study

Moradan

2016

Middle East J Rehabil Health

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Introduction: Most ovarian dermoid cysts occur during the reproductive age and therefore could occur during pregnancy. They are present in 0.03% of pregnancies and the risk of torsion during pregnancy is approximately 8%. They are bilateral in approximately 10% of cases. Diagnosis is usually made by ultrasound imaging. An ovarian cystectomy is almost always possible, even if it appears that only a small amount of ovarian tissue remains. Intraoperative spill of tumor contents may be a cause of complications. Case Presentation: A 28-year-old, pregnant, primipara female with gestational age 20 weeks + four days where referred to with complaint of pelvic mass that was incidentally reported in sonography where referred to the hospital. She had undergone intact removal (without spillage) of cysts during pregnancy by laporotomy and histopathologic report confirmed bilateral, multiple, benign and dermoid cyst. She was discharged without any complication on the second day after operation. She had an uneventful pregnancy and a cesarean delivery with alive, normal, female fetus at 38 weeks of gestation because of breech presentation. Conclusions: It seems that early diagnosis and intact surgery of multiple ovarian dermoid cysts during the second trimester of pregnancy could prevent complication of cysts and probably guarantee the prevention of adverse pregnancy outcome.

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Ovarian Teratoma

2016

Diagnostic Ultrasound: Abdomen and Pelvis

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Squamous cell carcinoma arising in an ovarian mature cystic teratoma complicating pregnancy

Cited by 11 publications

References 14 publications

Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a systematic review

Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a systematic review

Surgical Management of an Ovarian Bilateral Multiple Dermoid Cyst During Pregnancy: A Case Report Study

Ovarian Teratoma

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