Squamous cell carcinoma arising in ulcerated necrobiosis lipoidica diabeticorum

Uva, Luís; Freitas, João; Soares‐de‐Almeida, Luís; Vasques, Hugo; Moura, Cecília; Miguel, Diana; Filipe, Paulo

doi:10.1111/iwj.12206

Cited by 26 publications

(25 citation statements)

References 13 publications

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“…Necrobiosis lipoidica is a rare chronic granulomatous dermatitis characterized by plaques on the shins of tibia with red-brown edges and atrophic, yellow-brown, telangiectatic centers. [126][127][128] Although commonly asymptomatic, affected skin may be fragile and painful ulcerations develop in 25% to 33% of cases. 129,130 The pretibial region is the area typically affected and only rarely on hands, fingers, face, and scalp.…”

Section: Necrobiosis Lipoidica (Nl) Diabeticorummentioning

confidence: 99%

ISPAD Clinical Practice Consensus Guidelines 2018: Other complications and associated conditions in children and adolescents with type 1 diabetes

et al. 2018

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Section: Necrobiosis Lipoidica (Nl) Diabeticorummentioning

confidence: 99%

ISPAD Clinical Practice Consensus Guidelines 2018: Other complications and associated conditions in children and adolescents with type 1 diabetes

et al. 2018

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“…Caracteriza-se por máculo-pápulas brilhantes, telangiectásicas, amarelo-acastanhadas, com centro atrófico e contornos bem definidos e violáceos [7][8][9][10][11][12]. Apesar de habitualmente assintomáticas, constituindo um problema meramente estético, podem associar-se a prurido, disestesia e podem ocorrer ulcerações dolorosas, sobretudo após traumatismo [2,7,11].…”

Section: Discussionunclassified

“…A ulceração é a complicação mais frequente e pode surgir em 25-33% dos casos [2,10,11]. Raramente pode surgir carcinoma de células escamosas em áreas de NL [7,10].…”

Section: Discussionunclassified

Necrobiose lipoídica em adolescente com diabetes mellitus tipo 1: relato de caso

Gomes

Laranjo

Campos

et al. 2017

Sci Med

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Este artigo está licenciado sob forma de uma licença Creative Commons Atribuição 4.0 Internacional, que permite uso irrestrito, distribuição e reprodução em qualquer meio, desde que a publicação original seja corretamente citada. ABSTRACTAIMS: To report a case of necrobiosis lipoidica, a rare chronic granulomatous dermatosis. CASE DESCRIPTION: We present the case of a 17-year-old male adolescent, with type 1 diabetes mellitus from the age of four, followed in the Pediatric-Diabetology clinics of a level II hospital, under intensive regimen with multiple insulin administrations and poor metabolic control. At the age of 15, he noticed the appearance of an asymptomatic, erythematous, infiltrated, oval-shaped plaque, with a waxy whitish center, well-defined borders, 5 cm in diameter and progressive growth, located on the left forearm. The histological examination confirmed the diagnosis of necrobiosis lipoidica. He was treated with topical corticosteroid and emollient, thus stabilizing and reducing lesion infiltration. CONCLUSIONS: The authors highlight a rare dermatosis, non-pathognomonic of diabetes mellitus but related to this diagnosis in most cases. Its challenging recognition, especially in the presence of recent onset lesions, with atypical clinical presentation or in unusual sites, is fundamental in order to avoid erroneous or late treatments and its progression to ulceration.

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“…Although maintaining adequate glucose is essential for diabetes management, it is not thought to affect the course of NL 17. Rare cases of squamous cell carcinoma arising from NL have been reported 17 18…”

Section: Necrobiotic Granulomatous Conditionsmentioning

confidence: 99%

Non-infectious granulomatous conditions of the skin: a clinicopathological approach to diagnosis

2015

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Granulomatous disorders of the skin are diverse and include infectious and non-infectious conditions. They are a source of confusion to many dermatologists and pathologists, including even the most experienced dermatopathologists. Correlation with clinical picture, serology, microbiology and careful morphological examination is essential for accurate diagnosis. Most cases require ancillary histopathological studies to reach a final diagnosis. This review discusses important non-infectious granulomatous conditions of the skin and presents a practical approach when confronted with such entities.

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Squamous cell carcinoma arising in ulcerated necrobiosis lipoidica diabeticorum

Cited by 26 publications

References 13 publications

ISPAD Clinical Practice Consensus Guidelines 2018: Other complications and associated conditions in children and adolescents with type 1 diabetes

ISPAD Clinical Practice Consensus Guidelines 2018: Other complications and associated conditions in children and adolescents with type 1 diabetes

Necrobiose lipoídica em adolescente com diabetes mellitus tipo 1: relato de caso

Non-infectious granulomatous conditions of the skin: a clinicopathological approach to diagnosis

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