Squamous Cell Carcinoma Arising in a Chronic Osteomyelitic Sinus Tract With Metastasis

Malignant squamous cell carcinoma arising in a lumbar dermoid cyst

“…A squamous cell carcinoma may develop in a dermoid cyst in relation to prolonged chronic inflammation arising in sinus tracks, but there was no evidence of malignancy in the sinuses in our case [8]. The neoplastic transformation occurred only in the squamous epithelium, the other elements showing no evidence of dysplasia or neoplasia.…”

Pseudoepitheliomatous Hyperplasia vs. Squamous Cell Carcinoma Arising from Chronic Osteomyelitis of the Humerus

“…SCC arising from CO has an estimated incidence of 0.2 to 1.7% 5 . These patients are typically men in their 5th to 7th decade who have had CO for 20 to 50 years prior to the development of SCC 6 . The lower extremity is involved in about 85% of the instances of SCC arising from CO 7 .…”

Chronic Pancreatitis and Pancreatic Cancer

“…Already in 1863, the German pathologist Rudolf Virchow noted leucocytes in neoplastic tissues and made a connection between inflammation and cancer. Most of the early data were derived from descriptions of chronic cutaneous lesions, such as ulcers, burn scars or draining sinus tract [4,5]. Since then, the association between chronic inflammation and subsequent cancer has been recognized in many conditions (bladder cancer after schistosomiasis, ovarian cancer after pelvic inflammatory disease, esophageal cancer after Barrett's metaplasia, colorectal cancer after inflammatory bowel disease, ulcerative colitis and Crohn's disease, lung cancer and mesothelioma after silicosis or asbestosis and finally pancreas cancer after chronic pancreatitis).…”