Squamous cell carcinoma arising in a chronic perineal wound in a patient with long-standing cutaneous Crohn's disease

Lymphedematous verrucous changes of the genital skin: an extraintestinal manifestation of Crohn disease

“…Interestingly, this is in contrast to report of high‐grade dysplasia or carcinoma in 23% of patients with vulvar CD in a case series of 13 patients 11 . Squamous cell carcinoma with metastasis has been reported in patients with cutaneous CD 14 . Therefore, it is important to be aware that malignancy is in the clinicopathologic differential diagnosis of LVC.…”

Cutaneous Squamous Cell Carcinoma in Patients with Hidradenitis Suppurativa

“…All the case reports and series met the minimum quality assessment standard and were included in the meta-analysis ( Supplementary Table S1 ) [ 2 , 6 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ]. Selection bias cannot be excluded as most authors did not explicitly explain their selection method; therefore, there is a possibility that some cases of cSCC arising from HS wounds were not reported, underestimating the total number of cases currently in the literature.…”

Giant squamous cell carcinoma developed on a mesh-related enterocutaneous fistula: A case report

“…The pathophysiology of SCC on EF has not been described yet. Nevertheless, it is hypothesized that chronic inflammation found in EF epitheliums is similar to that observed in chronic scars and ulcers [ 12 , [15] , [16] , [17] ]. Constant tissue injury carries to epithelial regeneration, dysplasia, and carcinoma development, and this is mediated by the infiltration of inflammatory cells that provoke the release of tumor factors and cytokines that affect the cellular life cycle and angiogenesis, which occurs at the same time that oxygen-free radicals and other toxic mediators secondary to the inflammatory response are released, causing oxidative damage, thus altering the cellular nitrogenous bases [ 6 , 18 , 19 ].…”

“…In our case, the diagnosis was made incidentally. However, it is suggested that exacerbation of local signs and symptoms should raise cancer suspicion [ 12 , 17 ]. The recommendations for the treatment of enterocutaneous fistulas are usually based on resuscitation of the patient's volume, early diagnosis, and treatment of sepsis, early evaluation and management of the fistula, and nutritional and multidisciplinary approach [ 1 ].…”