Squamous Cell Carcinoma Arising from Inverted Schneiderian Papilloma: A Case Report with Oral Involvement

Abstract

Inverted Schneiderian papilloma is an uncommon benign tumor that presents tendency to recur and propensity to be associated with malignancy in approximately 10% of the cases. Some of these lesions are isolated in the maxillary sinus, and predominantly affect white males with mean age of 50 years. We report a case of squamous cell carcinoma arising from inverted Schneiderian papilloma in the maxillary sinus extending to the mouth. The patient was submitted to extraction of a maxillary molar tooth four months before the exacerbation of the symptoms of nasal airway obstruction and facial enlargement. Computed tomography scan revealed a sinonasal mass causing opacification of the right maxillary sinus with destruction of the lateral nasal wall and maxillary sinus floor. The patient was referred to an oncology center for treatment and died from tumor progression one year after the cancer was diagnosed. The intention of this report is to alert dentists to include the inverted Schneiderian papilloma, either associated with squamous cell carcinoma, or not, in the differential diagnosis of maxillary sinus tumors with aggressive behavior, which may extend to the oral cavity or involve roots of teeth.

Utilization of computer-aided detection system in diagnosing unilateral maxillary sinusitis on panoramic radiographs

“…17 Maxillary sinus carcinoma has been reported to be induced from Schneider papilloma. 18,19 Therefore, early diagnosis and treatment of maxillary sinus lesions is important. 20 CAD systems for chest radiographs have been developed to support the screening of lung lesions at group medical examinations.…”

Clinical evidence based review and systematic scientific review in the identification of malignant transformation of inverted papilloma

“…Location (Table 3) Most IP-SCC originated from the ethmoid region, maxillary sinus and lateral nasal wall [11]; however, there were multiple cases reporting IP-SCC in the middle ear, oral cavity, lacrimal sac and pituitary fossa [15][16][17][18][19][20]22]. A complete head and neck examination is recommended to follow up patients with IP, as IP can reoccur and transform into malignancy in the primary site, or in an alternate location.…”

Advances in recurrence and malignant transformation of sinonasal inverted papillomas

“…The spread of SIP may be mediated either due to migration via the eustachian tube or due to embryological migration of the Schneiderian mucosa into the middle ear (53,54). Garcia et al (55) reported that SIP/SCC in the maxillary sinus may extend to the mouth as an early symptom. Furthermore, as a common unilateral nasal occurrence, a case with a bilateral SIP involving both sides of frontal sinus was reported in Keskin et al (56).…”