Squamous cell carcinoma arising from mature cystic teratoma of the ovary: A challenging question for gynecologic oncologists

Gadducci, Angiolo; Guerrieri, Maria Elena; Cosio, Stefania

doi:10.1016/j.critrevonc.2018.10.005

Cited by 44 publications

(79 citation statements)

References 72 publications

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“…In the past 40 years, adenocarcinoma, sarcoma (2%), melanoma, basal cell carcinoma, and carcinoid were reported. Consistent with previous studies, ranking according to pathological type incidence rate, the most common histology arising in mature cystic teratoma is squamous cell carcinoma, followed by adenocarcinoma [1,6,10]. For several case reports, the age of patients with MT-MCT at diagnosis tended to be older than patients diagnosed with MCT.…”

Section: Discussionsupporting

confidence: 83%

Clinical Features and Survival Outcome of Patients with Malignant Transformation Arising in Mature Cystic Teratoma: A 20-Year Experience at Multicenter Institution and Literature Review on 342 Cases

Yang

Wang

2020

Preprint

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Background: To analyze the clinicopathologic characteristics and prognosis in malignant transformation of mature cystic teratoma (MT-MCT).Methods: We retrospectively reviewed 23 patients (cohort 3) diagnosed with MT-MCT from the medical center (Tongji Hospital and Hubei cancer hospital), between January 1990 to June 2020. Cohort 2 was obtained from the PubMed, CNKI, Web of Science, and MEDLINE database, between January 1990 to June 2020. Cohort 3 was based on the surveillance, epidemiology, and results registry (SEER) database, between January 1975 and December 2016. Results: Among 3865 cases diagnosed with mature cystic teratoma, the incidence of MT-MCT is 23 (0.59%). The mean age of 23 patients was 50.6 years (median 49.0, range 24 to71 years). Patients mainly had abdominal pain (21.7%) or complained about an abdominal mass (30.4%). The mean tumor size was 11.6 cm (median 11.9, range 5.2 to 14.8 cm). According to the FIGO stage, eight patients were in stage I (34.8%), two cases were in stage II (8.6%), III (47.8%), and IV (8.7%), respectively. Most patients were diagnosed with squamous cell carcinoma (91.3%). Most patients received total hysterectomy, salpingo-oophorectomy, and omentectomy. Five patients (21.7%) received lymphadenectomy. Platinum-based chemotherapy and radiotherapy were selectively used for patients after surgical resection. The mean of disease-free survival was 27.3 months (median 22.0, range 3.0 to 67.0 months). According to the published data analysis of 342 cases, the 1-, 3-, and 5-year overall survival rates were 53.2%, 33.1%, and 23.2%, respectively. The young patients (＜55 years) showed better prognosis. Conclusion: MT-MCT has an aggressive clinical course, with poor long-term prognosis. The high incidence in postmenopausal women should not be ignored. The effectiveness of adjuvant chemotherapy or radiotherapy after surgery is needed to elucidate in the future.

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Section: Discussionsupporting

confidence: 83%

Clinical Features and Survival Outcome of Patients with Malignant Transformation Arising in Mature Cystic Teratoma: A 20-Year Experience at Multicenter Institution and Literature Review on 342 Cases

Yang

Wang

2020

Preprint

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“…Although the minimally invasive route seems attractive in such situations due to a better recovery of the patient, certain authors have underlined the fact that this procedure should be avoided due to the high risk of spillage and cystic effraction during laparoscopic manipulation and extraction of the specimen (15,16). However, if laparoscopic approach is the option of in vivo 34: 2141-2146 (2020) choice and spillage occurs, adequate peritoneal washing with warmed fluids in strongly recommended in order to prevent the development of further peritoneal lesions (17). Moreover, more recent studies have come to demonstrate that the minimally invasive surgical procedure might be safely performed if the specimen is placed in an endoscopic bag of retrieval (18).…”

Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma from Abscessed, Mature Cystic Ovarian Teratoma – A Case Report and Literature Review

Bacalbaşa

Crețoiu

Hălmaciu

et al. 2020

In Vivo

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“…37 Squamous cell carcinomas (SCC) arising within mature cystic teratomas have a mean age of presentation of 55. 37 They are usually larger in size than a benign mature cystic teratoma 38 and have suspicious features on imaging studies. They either arise directly from the squamous teratomatous component, often in association with carcinoma-in-situ, or from squamous metaplasia in glandular epithelium.…”

Section: Mural Nodules In Mucinous Tumours Of Intestinal Typementioning

confidence: 99%

Uncommon ovarian epithelial tumours

Vroobel

Attygalle

2020

Diagnostic Histopathology

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Epithelial ovarian tumours represent the most common type of ovarian tumour. Most of malignant cases represent high-grade serous, clear cell and endometrioid carcinomas; borderline serous and mucinous tumours of intestinal type are less common. This review focuses on the uncommon or rare epithelial tumours of the ovary which include borderline and malignant Brenner tumours, the recently-described mesonephric-like carcinoma of the ovary, and primary ovarian neuroendocrine tumours, with emphasis on helpful and diagnostic features.

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Squamous cell carcinoma arising from mature cystic teratoma of the ovary: A challenging question for gynecologic oncologists

Cited by 44 publications

References 72 publications

Clinical Features and Survival Outcome of Patients with Malignant Transformation Arising in Mature Cystic Teratoma: A 20-Year Experience at Multicenter Institution and Literature Review on 342 Cases

Clinical Features and Survival Outcome of Patients with Malignant Transformation Arising in Mature Cystic Teratoma: A 20-Year Experience at Multicenter Institution and Literature Review on 342 Cases

Squamous Cell Carcinoma from Abscessed, Mature Cystic Ovarian Teratoma – A Case Report and Literature Review

Uncommon ovarian epithelial tumours

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