Squamous Cell Carcinoma Arising from an Epidermal Inclusion Cyst

Lee, Jinwon; Shin, Jin Yong; Roh, Si Gyun; Lee, Nae Ho; Yang, Kyung Moo

doi:10.5999/aps.2016.43.1.112

Cited by 6 publications

(7 citation statements)

References 5 publications

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“…The incidence of SCC developing from an epidermal inclusion cyst has been estimated to range from 0.011 to 0.045% [ 1 ]. After a review of the literature, we found 41 well-documented cases of SCC arising from cutaneous epidermal inclusion cysts [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. Our findings are summarized in Table 1 and Table 2 , which shows an increase in the number of reported cases of SCC arising from epidermal inclusion cysts since 2010.…”

Section: Discussionmentioning

confidence: 99%

Incidental Squamous Cell Carcinoma in an Epidermal Inclusion Cyst: A Case Report and Review of the Literature

et al. 2018

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Epidermal inclusion cysts are common lesions that rarely develop into squamous cell carcinoma (SCC). Neoplastic change in these cysts can be associated with prominent symptoms such as pain, rapid growth, or ulceration. This study describes the case of a 64-year-old woman with a 4-year history of a largely asymptomatic neck mass, which after routine excision was found to be an epidermal inclusion cyst harboring well-differentiated SCC. The diagnosis was made incidentally after routine cyst bisection and hematoxylin and eosin staining. Given the potential for variable presentation and low cost of hematoxylin and eosin analysis, we recommend a low threshold for a comprehensive pathological search for malignancy in excised cysts when appropriate.

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Section: Discussionmentioning

confidence: 99%

Incidental Squamous Cell Carcinoma in an Epidermal Inclusion Cyst: A Case Report and Review of the Literature

et al. 2018

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“…[2,7,9] Similarly, no cases of malignant transformation to squamous cell carcinoma were identified. [13][14][15][16][17][18][19] Finally, due to the rarity and long disease period of the disease, we could not elucidate an evident mechanism for the size difference between UGEC and MGECs. Instead, we performed clinical inferences through histological examination.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological characteristics and importance of lobulation of giant epidermal cysts: An 18-year retrospective review of 19 cases

et al. 2022

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Giant epidermal cysts, which have a diameter of ≥5 cm, have rarely been reported. Giant epidermal cysts that have multiple lobules are referred to as multilocular giant epidermal cysts. This study aims to establish the epidemiological characteristics and statistically determine the significance of lobulation in giant epidermal cysts.Data on 19 patients who developed giant epidermal cysts between January 2003 and February 2021 were retrospectively reviewed. Patients were divided into 2 groups based on the presence of septa and the differences in characteristics were analyzed.Among the 19 patients, 16 (84.2%) were male, and the mean age was 57.7 ± 10.6 years. The mean patient-reported tumor duration was 14.8 ± 12.5 years. Seven (36.8%) patients had multilocular giant epidermal cysts, whereas 12 (63.2%) had unilocular giant epidermal cysts. Compared with unilocular giant epidermal cysts, multilocular giant epidermal cysts had a significantly larger mean diameter (6.0 ± 0.7 vs 8.2 ± 1.8 cm, P = .02) and estimated volume (91.8 ± 43.3 vs 250.0 ± 157.0 mL, P = .02).Giant epidermal cysts have distinctive epidemiologic characteristics with predominance among males, those in their 50s, and a long tumor duration. Multilocular giant epidermal cysts are significantly larger in diameter and volume than unilocular ones.

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“…Penile in situ melanoma is a rare condition that initiates with the appearance of a pigmented lesion often located on the glans, 1 described by Muchinson et al in 1859, 3 yet, to this date there are almost 220 cases in literature. 1 Penile melanoma is a neuroectodermic layer melanocytes malignant transformation; 1 because it is located on penis, it could…”

Section: Discussionmentioning

confidence: 99%

“…In very rare circumstances, they undergo malignant transformation to a squamous cell carcinoma (SCC) without clinical hints suggesting the change. 1 Here, we report a case of a high-grade (AJCC eighth edition stage T3) SCC arising from a suspected EIC on the midforehead. Dermatologists and dermatologic surgeons alike should be aware of this phenomenon to appropriately diagnose and treat these tumors.…”

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confidence: 94%