Squamous cell carcinoma arising from chronic osteomyelitis

Alami, M.; Mahfoud, Mustapha; Bardouni, Ahmed El; Berrada, Mohamed Saleh; Yaacoubi, M. El

doi:10.3944/aott.2011.2537

Cited by 27 publications

(21 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite these data, in the present study, tumors showed no signals of metastatic disease at the moment of diagnosis in 83.3% ( n = 5) of patients. All six patients in the study by Alami et al 7 were staged as N0M0. In contrast, out of the seven patients in the study by Altay et al, 10 three were at the N0M0 stage; two, N1M0; one, N1M1; the other died prior to the staging.…”

Section: Discussionmentioning

confidence: 99%

“…Only two articles were case series: one with six and another with seven patients 1, 7, 10. Therefore, this series is one of the first to analyze a series of patients diagnosed with malignant transformation in the context of chronic osteomyelitis.…”

Section: Discussionmentioning

confidence: 99%

“…It is assumed that, in a multifactorial manner, the chronic inflammatory state behaves as a promoter in the complex process of carcinogenesis 1, 6. Malignant transformation begins in the skin or epithelium of the fistula and infiltrate the adjacent tissues, including bone 7, 8. The prevalence of malignant transformation in the setting of chronic osteomyelitis ranges from 1.6% to 23%, and the most commonly affected bones are the tibia and femur.…”

Section: Introductionmentioning

confidence: 99%

“…The definitive and most frequently used surgical treatment in these situations, considering that the majority of patients have advanced disease, is the proximal amputation of the neoplasia 7, 10. Adjuvant chemoradiotherapy is indicated in metastatic disease and high-grade tumors 14 .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Malignant transformation in chronic osteomyelitis

Moura

Ferreira

Garruço

2017

Revista Brasileira de Ortopedia (English Edition)

View full text Add to dashboard Cite

IntroductionCarcinomatous degeneration is a rare and late complication developing decades after the diagnosis of chronic osteomyelitis.ObjectivesTo present the results from a retrospective study of six cases of squamous cell carcinoma arising from chronic osteomyelitis.MethodsSix cases of chronic osteomyelitis related to cutaneous squamous cell carcinoma were identified. The cause and characteristics of the osteomyelitis were analyzed, as well as time up to malignancy, the suspicion signs for malignancy, the localization and histological type of the cancer, and the type and result of the treatment.ResultsThe mean time between osteomyelitis onset and the diagnosis of malignant degeneration was 49.17 years (range: 32–65). The carcinoma resulted from tibia osteomyelitis in five cases and from femur osteomyelitis in one. The pathological examination indicated cutaneous squamous cell carcinoma in all cases. All the patients were staged as N0M0, except for one, whose lomboaortic lymph nodes were affected. The treatment consisted of amputation proximal to the tumor in all patients. No patient presented signs of local recurrence and only one had carcinoma metastasis.ConclusionEarly diagnosis and proximal amputation are essential for prognosis and final results in carcinomatous degeneration secondary to chronic osteomyelitis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Malignant transformation in chronic osteomyelitis

Moura

Ferreira

Garruço

2017

Revista Brasileira de Ortopedia (English Edition)

View full text Add to dashboard Cite

show abstract

“…The conversion of chronic osteomyelitis to squamous cell carcinoma is a relatively rare event that often occurs decades after the primary insult. Prevention and early clinical diagnosis can lead to limb salvage; however, once seeded, the customary treatment is amputation of the affected extremity [5]. Cancer recurrence is rare after amputation; however, proximal migration of the bony infection is common.…”

Section: Discussionmentioning

confidence: 99%

Salvage of an Infected Below-Knee Amputation with Chlorhexidine and Bi-Layer Dermal Matrix: A Case Report

MoyerHunter

MinterJon

2016

Surgical Infections Case Reports

View full text Add to dashboard Cite

Background: Salvage of below-knee amputations is of utmost importance as studies have shown dramatically improved ambulation rates and overall outcomes. Multiple techniques of BKA stump preservation have been described in the literature, from conservative management to free tissue transfer, each with differing success and complication rates. Method: We present a staged treatment of a grossly infected BKA stump with minimal soft tissue coverage using aggressive debridement, intravenous antibiotics, chlorhexidine immersion, and staged bi-layer dermal matrix placement with interval split thickness skin grafting. Results: The patient is now twelve-months out from surgery and ambulating on a below-knee prosthetic limb without the need to replace the prosthetic limb. Conclusion: The adoption of chlorhexidine irrigation to the clinical algorithm has greatly aided in eradication of infection, dermal matrix engraftment and salvage of lower extremity wounds.

show abstract