Squamous cell carcinoma: 2021 updated review of treatment

Dreyfuss, Isabella; Kamath, Preetha; Frech, Fabio Stefano; Hernandez, Loren; Nouri, Keyvan

doi:10.1111/dth.15308

Cited by 14 publications

(13 citation statements)

References 46 publications

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“…Current methods for treatments in cSCC are surgical excision, adjuvant therapy, radiotherapy, systemic treatment and so on, and more effective therapies are still explored. [26,27] CRISPR/Cas9 was considered an adaptive immune system of bacteria and archaea that protect these microbial from the foreign virus. Now, CRISPR-Cas9 is used as a powerful versatile technology for programmable gene editing in various fields.…”

Section: Discussionmentioning

confidence: 99%

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A logic “OR” gate composed of a blue light‐induced CRISPR/dCas9 system and a Tet‐on system activates cancer suppressor genes to inhibit the growth of cutaneous squamous cell carcinoma cells

Huang

Wang

et al. 2022

Clinical and Translational Dis

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Optogenetic systems and tetracycline‐induced expression systems have been used in biological research. In gene circuits, light and tetracycline are often used to control the activation or inhibition of gene expression. In our study, we used a blue light induction system and tetracycline induction system to construct an “OR” logic gate, which can specifically induce the expression of p53 protein or E‐cadherin in the case of blue light or tetracycline, thus inhibiting the growth of cutaneous squamous cell carcinoma cells. Cutaneous squamous cell carcinoma is a kind of skin surface tumour. The activation of two tumour suppressor genes has a synergistic inhibitory effect on cutaneous squamous cell carcinoma, and blue light and tetracycline also provide a flexible means for gene regulation.

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Section: Discussionmentioning

confidence: 99%

“…Current methods for treatments in cSCC are surgical excision, adjuvant therapy, radiotherapy, systemic treatment and so on, and more effective therapies are still explored. [ 26,27 ]…”

Section: Discussionmentioning

confidence: 99%

A logic “OR” gate composed of a blue light‐induced CRISPR/dCas9 system and a Tet‐on system activates cancer suppressor genes to inhibit the growth of cutaneous squamous cell carcinoma cells

Huang

Wang

et al. 2022

Clinical and Translational Dis

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show abstract

“…The definition of clinical characteristics, diagnostic procedures, grading, staging, surgery, and non-invasive therapy must all be updated. Topical therapy, cryosurgery, photodynamic therapy, and radiation are among the non-surgical current therapies (Dreyfuss et al, 2022).…”

Section: Squamous Cell Carcinomamentioning

confidence: 99%

Ethosomes and their monotonous effects on Skin cancer disruption

Shinde

Page

Bhattacharya

2023

Front. Nanotechnol.

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Skin cancer is one of the most prominent diseases, affecting all continents worldwide, and has shown a significant rise in mortality and prevalence. Conventional therapy, including chemotherapy and surgery, has a few drawbacks. The ethosomal systems would be thoroughly reviewed in this compilation, and they would be classified based on constituents: classical ethosomes, binary ethosomes, and transethosomes. Ethosomes systems are model lipid vesicular carriers with a substantial portion of ethanol. The impacts of ethosomal system components, preparation techniques, and their major roles in selecting the final characteristics of these nanocarriers are comprehensively reviewed in this chapter. The special techniques for ethosomes, including the cold approach, hot approach, injection method, mechanical dispersion method, and conventional method, are explained in this chapter. Various evaluation parameters of ethosomes were also explained. Furthermore, ethosomal gels, patches, and creams can be emphasised as innovative pharmaceutical drug formulations. Some hybrid ethosomal vesicles possessing combinatorial cancer therapy using nanomedicine could overcome the current drug resistance of specific cancer cells. Through the use of repurpose therapy, phytoconstituents may be delivered more effectively. A wide range of in vivo models are employed to assess their effectiveness. Ethosomes have provided numerous potential skin cancer therapeutic approaches in the future.

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“…Cutaneous squamous cell carcinoma (SCC) is another common non-melanoma skin cancer that, unlike BCC, has the potential to metastasize. Early recognition and treatment are critical to reducing this risk, and actinic keratosis (AK) is considered a precursor lesion in SCC ( 46 ). Zhou et al., used an SD-OCT to image AK lesions of varying degrees in mice, which showed that the irregular wavy dermal-epidermal junction (DEJ) and persistent thickening of the epidermis are useful diagnostic parameters for AK.…”

Section: Application Of Oct In Oncologymentioning

confidence: 99%

Research progress on the application of optical coherence tomography in the field of oncology

et al. 2022

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Optical coherence tomography (OCT) is a non-invasive imaging technique which has become the “gold standard” for diagnosis in the field of ophthalmology. However, in contrast to the eye, nontransparent tissues exhibit a high degree of optical scattering and absorption, resulting in a limited OCT imaging depth. And the progress made in the past decade in OCT technology have made it possible to image nontransparent tissues with high spatial resolution at large (up to 2mm) imaging depth. On the one hand, OCT can be used in a rapid, noninvasive way to detect diseased tissues, organs, blood vessels or glands. On the other hand, it can also identify the optical characteristics of suspicious parts in the early stage of the disease, which is of great significance for the early diagnosis of tumor diseases. Furthermore, OCT imaging has been explored for imaging tumor cells and their dynamics, and for the monitoring of tumor responses to treatments. This review summarizes the recent advances in the OCT area, which application in oncological diagnosis and treatment in different types: (1) superficial tumors:OCT could detect microscopic information on the skin’s surface at high resolution and has been demonstrated to help diagnose common skin cancers; (2) gastrointestinal tumors: OCT can be integrated into small probes and catheters to image the structure of the stomach wall, enabling the diagnosis and differentiation of gastrointestinal tumors and inflammation; (3) deep tumors: with the rapid development of OCT imaging technology, it has shown great potential in the diagnosis of deep tumors such in brain tumors, breast cancer, bladder cancer, and lung cancer.

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Squamous cell carcinoma: 2021 updated review of treatment

Cited by 14 publications

References 46 publications

A logic “OR” gate composed of a blue light‐induced CRISPR/dCas9 system and a Tet‐on system activates cancer suppressor genes to inhibit the growth of cutaneous squamous cell carcinoma cells

A logic “OR” gate composed of a blue light‐induced CRISPR/dCas9 system and a Tet‐on system activates cancer suppressor genes to inhibit the growth of cutaneous squamous cell carcinoma cells

Ethosomes and their monotonous effects on Skin cancer disruption

Research progress on the application of optical coherence tomography in the field of oncology

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