Squamous carcinoma arising in benign cystic teratoma of the ovary.A report of four cases and review of the literature

Krumerman, Martin; Chung, Arthur F.

doi:10.1002/1097-0142(197703)39:3<1237::aid-cncr2820390332>3.0.co;2-l

Cited by 77 publications

(27 citation statements)

References 10 publications

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“…The reported incidence was 2.8% by Krumerman & Chung. [19] In our series also we had one case of moderately differentiated squamous cell carcinoma, giving the incidence of 5.26%, which is comparatively a higher figure. But the Indian authors like Tyagi et al documented this change in 4% (1 out of 25 cases).…”

Section: Germ Cell Tumorsmentioning

confidence: 65%

Study of morphological patterns of ovarian neoplasms

Tejeswini¹

2013

IOSR-JDMS

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Section: Germ Cell Tumorsmentioning

confidence: 65%

Study of morphological patterns of ovarian neoplasms

Tejeswini¹

2013

IOSR-JDMS

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“…In this study, the 3 pure OSCC showed strong p16 positivity, which was diffuse in 2, whereas only in 1 of the 2 OSCC associated with a dermoid cyst showed moderate p16 staining, the other being negative. The origin of OSCC in dermoid cysts has been ascribed to dysplastic changes in the squamous epithelium (59)(60)(61) or in the columnar epithelium that has undergone squamous metaplasia (59,62,63). Most ovarian carcinomas arising in the endometriosis are of endometrioid and clear cell types.…”

mentioning

confidence: 99%

p16 Expression in Squamous and Trophoblastic Lesions of the Upper Female Genital Tract

Chew

Post²,

Carinelli³

et al. 2010

International Journal of Gynecological Pathology

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p16, a surrogate marker for human papillomavirus (HPV) infection, is uniformly present in HPV-related carcinomas. This study aims to further characterize p16 expression in trophoblastic lesions and squamous lesions of the upper female genital tract, as little data exists. p16 immunostaining was performed on sections from ichthyosis uteri (1), primary uterine corpus squamous cell carcinoma (UCSCC) (2), primary ovarian SCC (OSCC) (5; 2 associated with a dermoid cyst), endometrial endometrioid adenocarcinoma with extensive squamous differentiation (EC-SD) (5), ovarian endometrioid adenocarcinoma with extensive squamous differentiation (OC-SD) (4), placental site nodule (5), and placental site trophoblastic tumor (PSTT) (6). We evaluated the percentage of positive cytoplasmic and nuclear staining (focal ≤10%, multifocal=10% to 50%, and diffuse ≥50%) and staining intensity (weak, moderate, and strong). HPV-DNA analysis by polymerase chain reaction was performed on 5 OSCC. Ichthyosis uteri, all UCSCC and 1 OSCC (arising in a dermoid) were negative; the other dermoid-associated OSCC showed focal moderate staining, the remaining OSCC displayed strong (100%), diffuse (2), or multifocal (1) p16 positivity. Three of the 5 EC-SD cases showed strong diffuse staining of the squamous component. The glandular component focally showed strong p16 positivity (2), with variably intense focal staining in 3 cases. The squamous component of all OC-SD showed focal moderate staining, with variable staining of the glandular component. Overall, 3 EC-SD had 80% to 90% p16 positivity. Five of the 5 placental site nodules and 4 of the 6 PSTT showed focal weak staining, whereas 2 PSTT were p16 negative. HPV-DNA analysis was negative in 3 of the 5 OSCC, the other 2 cases being technical failures. p16 is expressed in OSCC and in the squamous and glandular components of EC-SD and OC-SD. As p16 is negative in UCSCC, it may help to identify the origin of SCC diffusely involving the corpus and cervix, and suggests different pathogeneses for SCC of the upper female genital tract, likely to be unrelated to HPV infection. In contrast to earlier data, we found weak and focal p16 expression in trophoblastic lesions. Thus, when considering the differential diagnosis of cervical SCC and trophoblastic lesions, only strong diffuse p16 staining should be considered helpful.

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“…Malignancy in MOCT has been reported in several reviews [4,5,15,16,21,24,25,27]. In 1993 Carlson and Wheeler [3] recorded 14 cases of malignant melanoma in MOCT.…”

Section: Discussionmentioning

confidence: 99%

Mature ovarian cystic teratoma with combined squamous cell carcinoma and malignant melanoma

1998

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In a mature ovarian cystic teratoma (MOCT) in a 67-year-old woman we found associated invasive squamous cell carcinoma and nodular amelanotic malignant melanoma. The finding of foci of typical and atypical melanocytic proliferation at the junctional level of the dermal component together with the absence of other possible sources supports an ovarian origin of the melanoma. A comparative analysis of the reported MOCT-associated malignant melanomas emphasizes the singularity of our case in the amelanotic character of the melanoma, its lymphotropism and the coexistence of invasive squamous cell carcinoma.

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Squamous carcinoma arising in benign cystic teratoma of the ovary.A report of four cases and review of the literature

Cited by 77 publications

References 10 publications

Study of morphological patterns of ovarian neoplasms

Study of morphological patterns of ovarian neoplasms

p16 Expression in Squamous and Trophoblastic Lesions of the Upper Female Genital Tract

Mature ovarian cystic teratoma with combined squamous cell carcinoma and malignant melanoma

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