Squalene-based multidrug nanoparticles for improved mitigation of uncontrolled inflammation in rodents

Dormont, Flavio; Brusini, Romain; Cailleau, Catherine; Reynaud, Franceline; Peramo, Arnaud; Gendron, Amandine; Mougin, Julie; Gaudin, Françoise; Varna, Mariana; Couvreur, Patrick

doi:10.1126/sciadv.aaz5466

Cited by 91 publications

(93 citation statements)

References 59 publications

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“…Dormont et al used squalene, an endogenous lipid for preparing nanoparticles loaded with the anti-inflammatory drugs adenosine and alpha-tocopherol (vitamin E), for targeted action in regions of acute inflammation [147]. Mice in an acute hyperinflammatory state and with cytokine storm were treated with squalene nanoparticles, and a reduction in the levels of pro-inflammatory cytokines and an increase in the levels of IL-10 were observed, mitigating uncontrolled inflammation.…”

Section: Carriers and Drug Delivery Systems With Potential To Controlmentioning

confidence: 99%

How can nanotechnology help to combat COVID-19? Opportunities and urgent need

et al. 2020

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Incidents of viral outbreaks have increased at an alarming rate over the past decades. The most recent human coronavirus known as COVID-19 (SARS-CoV-2) has already spread around the world and shown R 0 values from 2.2 to 2.68. However, the ratio between mortality and number of infections seems to be lower in this case in comparison to other human coronaviruses (such as severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV)). These outbreaks have tested the limits of healthcare systems and have posed serious questions about management using conventional therapies and diagnostic tools. In this regard, the use of nanotechnology offers new opportunities for the development of novel strategies in terms of prevention, diagnosis and treatment of COVID-19 and other viral infections. In this review, we discuss the use of nanotechnology for COVID-19 virus management by the development of nano-based materials, such as disinfectants, personal protective equipment, diagnostic systems and nanocarrier systems, for treatments and vaccine development, as well as the challenges and drawbacks that need addressing.

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Section: Carriers and Drug Delivery Systems With Potential To Controlmentioning

confidence: 99%

How can nanotechnology help to combat COVID-19? Opportunities and urgent need

et al. 2020

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“…In addition, our group recently developed a novel antioxidant/anti-inflammatory multidrug squalene-based nanoparticle formulation, allowing simultaneous delivery of adenosine and tocopherol in tandem to targeted sites by exploiting dysfunctions of the endothelial barrier at the sites of acute inflammation. These nanoparticles demonstrated promising antiinflammatory and protective effects in mice models of endotoxemia and lethal systemic shock, with potential to treat uncontrolled inflammation associated with many diseases, including severe COVID-19 [129].…”

Section: Other Applications Of Nanoparticles For Immune System Modulamentioning

confidence: 99%

Advanced nanomedicines for the treatment of inflammatory diseases

Brusini

Varna

Couvreur

2020

Advanced Drug Delivery Reviews

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130

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Inflammation, a common feature of many diseases, is an essential immune response that enables survival and maintains tissue homeostasis. However, in some conditions, the inflammatory process becomes detrimental, contributing to the pathogenesis of a disease. Targeting inflammation by using nanomedicines (i.e. nanoparticles loaded with a therapeutic active principle), either through the recognition of molecules overexpressed onto the surface of activated macrophages or endothelial cells, or through enhanced vasculature permeability, or even through biomimicry, offers a promising solution for the treatment of inflammatory diseases. After providing a brief insight on the pathophysiology of inflammation and current therapeutic strategies, the review will discuss, at a pre-clinical stage, the main innovative nanomedicine approaches that have been proposed in the past five years for the resolution of inflammatory disorders, finally focusing on those currently in clinical trials.

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“…The formulation was tested in mice in a state of hyperinflammation and suffering from cytokine storm to mimic the condition of COVID-19. A significant decrease in TNF-α along with an increase in antiinflammatory cytokine interleukin-10 was observed [293].…”

Section: Nanotechnological Approaches Currently Under Investigation Amentioning

confidence: 97%

Nanotechnology-based antiviral therapeutics

Chakravarty

Vora

2020

Drug Deliv. and Transl. Res.

200

165

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The host immune system is highly compromised in case of viral infections and relapses are very common. The capacity of the virus to destroy the host cell by liberating its own DNA or RNA and replicating inside the host cell poses challenges in the development of antiviral therapeutics. In recent years, many new technologies have been explored for diagnosis, prevention, and treatment of viral infections. Nanotechnology has emerged as one of the most promising technologies on account of its ability to deal with viral diseases in an effective manner, addressing the limitations of traditional antiviral medicines. It has not only helped us to overcome problems related to solubility and toxicity of drugs, but also imparted unique properties to drugs, which in turn has increased their potency and selectivity toward viral cells against the host cells. The initial part of the paper focuses on some important proteins of influenza, Ebola, HIV, herpes, Zika, dengue, and corona virus and those of the host cells important for their entry and replication into the host cells. This is followed by different types of nanomaterials which have served as delivery vehicles for the antiviral drugs. It includes various lipid-based, polymer-based, lipid-polymer hybrid-based, carbon-based, inorganic metal-based, surface-modified, and stimuli-sensitive nanomaterials and their application in antiviral therapeutics. The authors also highlight newer promising treatment approaches like nanotraps, nanorobots, nanobubbles, nanofibers, nanodiamonds, nanovaccines, and mathematical modeling for the future. The paper has been updated with the recent developments in nanotechnology-based approaches in view of the ongoing pandemic of COVID-19.

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Squalene-based multidrug nanoparticles for improved mitigation of uncontrolled inflammation in rodents

Cited by 91 publications

References 59 publications

How can nanotechnology help to combat COVID-19? Opportunities and urgent need

How can nanotechnology help to combat COVID-19? Opportunities and urgent need

Advanced nanomedicines for the treatment of inflammatory diseases

Nanotechnology-based antiviral therapeutics

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