Sputum Induction in Children Is Feasible and Useful in a Bustling General Hospital Practice

Bart, Ingeborg Y.; Mourits, M.; Gent, René van; Leuken, Maarten H van; Hilbink, Mirrian; Warris, Adilia; Wever, Peter C.; Vries, Esther de

doi:10.1177/2333794x16636504

Cited by 6 publications

(6 citation statements)

References 10 publications

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“…IS had better diagnostic performance when compared to other specimens in the main study, and explains the higher percentage of etiological identification when compared with other studies (Ferrari C et al, 2007). In previous studies, 75%-91% of IS samples were considered good quality (Bart et al, 2016;Lahti et al, 2009). In our study 73% of IS samples were considered of good quality and appropriate to undergo testing with different microbiological procedures.…”

Section: Discussionmentioning

confidence: 63%

Induced sputum as an adequate clinical specimen for the etiological diagnosis of community-acquired pneumonia (CAP) in children and adolescents

Rueda

Bermúdez

Restrepo

et al. 2022

International Journal of Infectious Diseases

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Section: Discussionmentioning

confidence: 63%

Induced sputum as an adequate clinical specimen for the etiological diagnosis of community-acquired pneumonia (CAP) in children and adolescents

Rueda

Bermúdez

Restrepo

et al. 2022

International Journal of Infectious Diseases

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“…A total (89/98; 91%) had good quality sputum, and bacterial pathogens were isolated from 22/89 (25%). 13 In India, IS was performed in 120 children diagnosed with pneumonia. There was good quality sputum in 64 children (53.3%).…”

Section: Discussionmentioning

confidence: 99%

Performance and safety of the induced sputum procedure in young children in Malawi: a prospective study

Nyangulu

Thole

Chikhoza

et al. 2021

Transactions of the Royal Society of Tropical Medicine and Hygiene

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Background Collecting sputum specimens is a challenge in infants and young children. We assessed the performance and safety of induced sputum (IS) collection in this population, embedded in a prospective study evaluating respiratory cryptosporidiosis in Malawian children with diarrheal disease. Methods We assessed the sputum quality and correlation with detection of Cryptosporidium spp. and evaluated safety and adverse events in 162 children. Results Among 159 stool specimens tested, 34 (21%, 95% CI 15.0 to 28%) were positive for Cryptosporidium spp. There were 160 IS and 161 nasopharyngeal (NP) specimens collected. IS and NP specimen collection was performed for each patient. The majority of IS specimens (122/147; 83%) were clear in appearance and 132/147 (90%) were of good quality. Among the respiratory specimens tested, 10 (6.3%, 95% CI 2.5 to 10%) IS and 4 (3%, 95% CI 0 to 5%) NP were positive for Cryptosporidium spp. When stool cryptosporidium PCR was the gold standard, IS PCR sensitivity was higher (29%, 95% CI 22 to 37%) compared with NP PCR (12%, 95% CI 7 to 17%) for detection of Cryptosporidium spp. One (0.4%) adverse event occurred, consisting of a drop in oxygen saturations at the 30-min postprocedure evaluation. Consciousness level, median respiratory rate and oxygen saturations were unchanged, before or after IS. Conclusions IS provides good quality specimens, is more sensitive than NP specimens for diagnosis of respiratory cryptosporidiosis, and collection can be performed safely in children hospitalized with diarrheal disease.

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“…In another study in The Netherlands of children admitted with acute lower respiratory infection, 98 children had IS done. A total 89/98 (91%) had good quality sputum, and bacterial pathogens were isolated from 22/89 (25%) (12). In India, IS was done in 120 children diagnosed with pneumonia.…”

Section: Discussionmentioning

confidence: 99%

Performance and safety of induced sputum procedure in young children in Malawi: a prospective study

Nyangulu

Thole

Chikhoza

et al. 2021

Preprint

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BackgroundCollecting sputum specimens are a challenge in infants and young children. We assessed performance and safety of induced sputum (IS) collection in this population, embedded in a prospective study evaluating respiratory cryptosporidiosis in Malawian children with diarrheal disease.MethodsWe assessed sputum quality and correlation with detection of cryptosporidium, and evaluated safety and adverse events in 162 children.ResultsAmong 159 stool specimens tested, 34 (21%, 95% CI 15.0 – 28%) were positive for Cryptosporidium spp. There were160 IS and 161 nasopharyngeal (NP) specimens collected. The majority of IS specimens 122/147 (83%) were clear in appearance, and 132/147 (90%) were of good quality. Among the respiratory specimens tested, 10 (6.3%, 95% CI 2.5 - 10) IS and 4 (3% (95% CI 0 – 5)) NP were positive for Cryptosporidium spp. When stool cryptosporidium PCR was the gold standard, IS PCR sensitivity was higher (29 %, 95% CI 22 – 37) compared to NP PCR (12%, 95% CI 7 – 17) for detection of Cryptosporidium spp. One (0.4%) adverse event occurred, a drop in oxygen saturations at 30-minute post procedure evaluation. Consciousness – level, median respiratory rate and oxygen saturations were unchanged, before or after IS.ConclusionsIS provides good quality specimens, is more sensitive than NP specimens for diagnosis of respiratory cryptosporidiosis, and collection can be done safely in children hospitalized with diarrheal disease.

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Sputum Induction in Children Is Feasible and Useful in a Bustling General Hospital Practice

Cited by 6 publications

References 10 publications

Induced sputum as an adequate clinical specimen for the etiological diagnosis of community-acquired pneumonia (CAP) in children and adolescents

Induced sputum as an adequate clinical specimen for the etiological diagnosis of community-acquired pneumonia (CAP) in children and adolescents

Performance and safety of the induced sputum procedure in young children in Malawi: a prospective study

Performance and safety of induced sputum procedure in young children in Malawi: a prospective study

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