Sputum Eosinophilia, Airway Hyperresponsiveness and Airway Narrowing in Young Adults with Former Asthma

Abstract

This study shows that subjects with long-term outgrown asthma continue to have airway eosinophilic inflammation, airway hyperresponsiveness and airway narrowing.

A case‐control study of the relation between plasma selenium and asthma in European populations: a GA2LEN project*

“…Teenagers who are asymptomatic could actually have pathological signs of sub-clinical asthma, persistent BHR, airway inflammation and thickening of the reticular layer of the airways basement membrane (73)(74)(75). On the basis of these large numbers of converging observations, current hypotheses focus on epithelial barrier function and it has been suggested that in asthma a structurally and functionally defective lower airways epithelium underlies abnormal responses to the inhaled environment leading to enhanced signalling between the airway epithelium and the Epithelial-Mesenchymal Trophic Unit (EMTU) and immune cells (76).…”

Blood eosinophil counts during bronchiolitis are related to bronchial hyper‐responsiveness and lung function in early adolescence

“…Even though there was not a strong association between the level of eosinophils during bronchiolitis and subsequent asthma, increased BHR may represent risk factors for future development of asthma, as indicated by other studies (1). Others have reported a continuing eosinophilic airway inflammation, BHR and airway narrowing in young adults with outgrown asthma (24). In the Tucson's study, BHR at the age of six was independently associated with asthma at the age of 22 (25).…”

1H–NMR Metabolomic Biomarkers of Poor Outcome after Hemorrhagic Shock are Absent in Hibernators

“…Surprisingly, both groups of animals avoided anaerobic glucose metabolism during I/R, consistent with resistance from I/R injury. DBHB is protective during I/R [49]–[52], presumably from the ketone bodies direct entrance into the TCA cycle and the avoidance of the conversion of pyruvate to lactate and development of acidosis [53]–[55]. Similar metabolomes in both groups of AGS suggest that metabolic flexibility persists in AGS during the summer season.…”