Sputum Cytology for the Diagnosis of Lung Cancer

Erkılıç, Suna; Özsaraç, Coşkun; Küllü, Sevgi

doi:10.1159/000326639

Cited by 23 publications

(3 citation statements)

References 6 publications

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“…3 The accuracy of the cell block is high, particularly in histological typing of cancer 4 and increases the sensitivity and specificity of sputum cytology. 5 Our results are comparable with other identical studies. Therefore preparing a cell block is highly advocated in every fluid sample if it is feasible.…”

supporting

confidence: 92%

Comparison of smear cytology and cell blocks in detection of respiratory cancer

Shafigh¹,

Siadaty²

2005

Annals of Saudi Medicine

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supporting

confidence: 92%

Comparison of smear cytology and cell blocks in detection of respiratory cancer

Shafigh¹,

Siadaty²

2005

Annals of Saudi Medicine

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“…Previous studies have shown that the sensitivity of this sample is much less than other samples [8], [25], [26]. For example, Choi and colleagues compared 955 sputum specimens that were prepared by both TP and CP.…”

Section: Discussionmentioning

confidence: 99%

Application of ThinPrep Bronchial Brushing Cytology in the Early Diagnosis of Lung Cancer: A Retrospective Study

et al. 2014

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The majority of lung cancer patients are diagnosed at advanced stages of disease. This study evaluated the diagnostic value of ThinPrep (TP) bronchial brushing cytology in lung cancer. A total of 595 patients with suspicious lung cancer were enrolled in this study. The bronchial brushing samples were prepared by TP. The data were then compared to histology of lung tissue samples. Histologically, 479 of these 595 patients were diagnosed with lung cancer, including 223 cases of lung squamous cell carcinoma (SCC), 77 cases of lung adenocarcinoma (ADC), and 152 cases of small cell lung carcinoma (SCLC). The TP cytology revealed a total of 460 cases of lung cancer (including 232 SCCs, 91 ADCs, and 108 SCLCs). The TP cytological technique had 87.06% sensitivity and 62.93% specificity in the diagnosis of lung cancer. Specifically, TP cytology confirmed 195 of 223 SCCs, 47 of 77 ADCs, and 94 of 152 SCLCs. The TP cytology showed 87.44% sensitivity and 90.05% specificity for the diagnosis of SCC, with a Matthew's correlation coefficient (MCC) of 0.820; while the sensitivity was reduced to 61.04% and the specificity was 90.93% for the diagnosis of ADC, with a MCC of 0.464. For the diagnosis of SCLC, the sensitivity was 61.84% and the specificity was 96.84%, with a MCC of 0.648. Thus, this study demonstrated the usefulness of TP bronchial brushing cytology in the early diagnosis of lung cancer, especially the early stage of lung SCC. A prospective clinical trial will verify these data before being translated into the clinic.

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“…The corresponding specificity was 99.5%, 100% and 99.5% for the three groups respectively. 9 The decreased Sensitivity to pick up malignancies can be attributed to the lack of robust processing methods to retrieve all the diagnostic materials clogged in mucus, inflammatory exudates and blood. 10…”

Section: Discussionmentioning

confidence: 99%

Pathological spectrum of lung lesions diagnosed by sputum cytology: A three years retrospective study in a tertiary health care centre of North India

Gangopadhyay,

Siddiqui

2023

ACHR

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Sputum Cytology is a cheap and noninvasive investigation contributing significantly to the workload of Cytopathology Laboratories. However, over the years, the use of Sputum Cytology has depreciated. It has been taken over by more advanced procedures like Broncho Alveolar Lavage and Trans Bronchial Needle Aspiration, which are comparatively invasive and expensive requiring a much higher learning curve. Hence, the usefulness of noninvasive samples like Sputum needs to be explored in resource limited settings.To study the spectrum of Lung lesions diagnosed using Sputum Cytology with Histopathological correlation wherever possible.: This was a three years retrospective study. Data of patients who had come with sputum sample was retrieved from the archives of the cytopathology lab between July 2019 and June 2022. Cytology findings were correlated with histopathological diagnosis, wherever possible.Out of the total sample size of 143, 67 showed inflammatory infiltrate, 1 out of which was confirmed to be malignant on biopsy. 17 cases were suspected to be malignant, out of which 15 were confirmed on biopsy. Other samples revealed the presence of fungal infection, dysplasia with no frank malignancy and reactive changes.Our study shows that sputum testing can be quite an accurate method in the early diagnosis of many lung lesions including malignancies. The Sensitivity and Specificity for malignancy was 83.33% and 95% respectively. Therefore, it can be applied as a cheaper, noninvasive ideal screening test for the early detection of lung pathologies especially in resource poor settings.

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Sputum Cytology for the Diagnosis of Lung Cancer

Cited by 23 publications

References 6 publications

Comparison of smear cytology and cell blocks in detection of respiratory cancer

Comparison of smear cytology and cell blocks in detection of respiratory cancer

Application of ThinPrep Bronchial Brushing Cytology in the Early Diagnosis of Lung Cancer: A Retrospective Study

Pathological spectrum of lung lesions diagnosed by sputum cytology: A three years retrospective study in a tertiary health care centre of North India

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