Sputtered Gum metal thin films showing bacterial inactivation and biocompatibility

Achache, Sofiane; Alhussein, Akram; Lamri, Salim; François, Manuel; Sanchette, Frédéric; Pulgarín, C.; Kiwi, J.

doi:10.1016/j.colsurfb.2016.07.007

Cited by 12 publications

(7 citation statements)

References 29 publications

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“…Hsieh et al have reported TaN–(Ag,Cu) nanocomposite antibacterial films prepared by magnetron sputtering at room temperature . Direct current magnetron sputtering (DCMS) and high-power impulse magnetron sputtering (HIPIMS) have been shown to be effective in the preparation of uniform, adhesive thin antibacterial films on textiles. , Our laboratory has recently reported Ag– and Cu–MeN, −MeON, and −MeO x (Me = Ti, Zr, and Ta) films sputtered on textile and polymer films leading to efficient bacterial inactivation. , Energetic ions in a well-designed reactor atmosphere lead to the deposition of metals/bimetals/oxides with controlled sizes, redox properties, and hydrophobic/hydrophilic balance leading to fast bacterial inactivation. ,,,,− …”

Section: Introductionmentioning

confidence: 99%

Innovative Ti_1–xNb_xN–Ag Films Inducing Bacterial Disinfection by Visible Light/Thermal Treatment

Rtimi

Karimi

Sanjinés

2018

ACS Appl. Mater. Interfaces

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This study presents innovative TiNb N-Ag films obtained by a suitable combination of low-energy and high-energy sputtering leading to bacterial inactivation. The bacterial inactivation kinetics by the TiNbN layers was drastically enhanced by the addition of 6-7% Ag and proceeded to completion within 3 h after the film autoclaving. By X-ray photoelectron spectroscopy (XPS), the samples after autoclaving presented in their upper layers TiO, NbO and AgO with a surface composition of TiNbNAg. Surface potential/pH changes in the TiNb N-Ag films were monitored during bacterial inactivation. Surface redox processes during the bacterial inactivation were detected by XPS. The diffusion of Ag in the TiNb N-Ag films was followed at 50 and 70 °C pointing. The beneficial thermal treatment points out to the bifunctional bacterial inactivation properties of these films and their potential application in healthcare facilities. Interfacial charge transfer (IFCT) under light irradiation between AgO, NbO and TiO is suggested consistent with the data found during the course of this study. The TiO/NbO lattice mechanism is discussed in the framework of the Verwey's controlled valence model. The surface properties of the TiNb N-Ag films were investigated by X-ray diffraction, atomic force microscopy, and scanning electron microscopy.

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Section: Introductionmentioning

confidence: 99%

Innovative Ti_1–xNb_xN–Ag Films Inducing Bacterial Disinfection by Visible Light/Thermal Treatment

Rtimi

Karimi

Sanjinés

2018

ACS Appl. Mater. Interfaces

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“…Many copper-based coatings such as TiO 2 -Cu, Cu, Ti, Nb, and their oxides were developed and investigated, mainly for their antibacterial properties. In our previous studies [13][14][15], we reported the mechanical properties of a superelastic Ti-based GMTF showing increased bacterial inactivation under light concomitant to a biocompatible property in darkness [16,17]. We also showed the effect of copper content on the structure, morphology, and mechanical properties of GMTF [18].…”

Section: Introductionmentioning

confidence: 71%

Architectured Cu–TNTZ Bilayered Coatings Showing Bacterial Inactivation under Indoor Light and Controllable Copper Release: Effect of the Microstructure on Copper Diffusion

et al. 2020

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A Ti–23Nb–0.7Ta–2Zr–1.2O alloy (at %), called “gum metal”, was deposited by direct-current magnetron sputtering (DCMS) on an under layer of copper. By varying the working pressure during the deposition, columnar TNTZ (Ti–Nb–Ta–Zr) nanoarchitectures were obtained. At low working pressures, the upper layer was dense with a coarse surface (Ra = 12 nm) with a maximum height of 163 nm; however, the other samples prepared at high working pressures showed columnar architectures with voids and an average roughness of 4 nm. The prepared coatings were characterized using atomic force microscopy (AFM) for surface topography, energy dispersive X-ray spectroscopy (EDX) for atomic mapping, scanning electron microscopy (SEM) for cross-section imaging, contact angle measurements for hydrophilic/hydrophobic balance of the prepared surfaces, and X-ray diffraction (XRD) for the crystallographic structures of the prepared coatings. The morphology and the density of the prepared coatings were seen to influence the hydrophilic properties of the surface. The antibacterial activity of the prepared coatings was tested in the dark and under low-intensity indoor light. Bacterial inactivation was seen to happen in the dark from samples presenting columnar nanoarchitectures. This was attributed to the diffusion of copper ions from the under layer. To verify the copper release from the prepared samples, an inductively coupled plasma mass spectrometer (ICP-MS) was used. Additionally, the atomic depth profiling of the elements was carried out by X-ray photoelectron spectroscopy (XPS) for the as-prepared samples and for the samples used for bacterial inactivation. The low amount of copper in the bulk of the TNTZ upper layer justifies its diffusion to the surface. Recycling of the antibacterial activity was also investigated and revealed a stable activity over cycles.

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“…3/discussion) and the crystallization degree of TNTZ-(Cu) obtained by XRD (Fig. 4a/discussion) play an important role controlling the activity of the TNTZ-(Cu) x surface leading to bacterial inactivation [15]. Fig.…”

Section: Morphology and Surface Topography Of Films Observed By Sem Amentioning

confidence: 92%

“…; TiO 2 -Cu and Cu, Ti, Nb and their oxides were developed and investigated for their antibacterial properties. Achache et al [13,14] have recently reported the mechanical properties of super-elastic Ti-based gum metal thin films showing increased bacterial inactivation properties and biocompatibility [15,16]. The present study focuses on the effect of copper content on the structure, morphology and mechanical properties of these asdeposited films.…”

Section: Introductionmentioning

confidence: 91%

Beneficial effect of Cu on Ti-Nb-Ta-Zr sputtered uniform/adhesive gum films accelerating bacterial inactivation under indoor visible light

Alhussein

Achache

Déturche

et al. 2017

Colloids and Surfaces B: Biointerfaces

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a b s t r a c tThis article presents the evidence for the significant effect of copper accelerating the bacterial inactivation on Ti-Nb-Ta-Zr (TNTZ) sputtered films on glass up to a Cu content of 8.3 at.%. These films were deposited by dc magnetron co-sputtering of an alloy target Ti-23Nb-0.7Ta-2Zr (at.%) and a Cu target. The fastest bacterial inactivation of E. coli on this later TNTZ-Cu surface proceeded within ∼75 min. The films deposited by magnetron sputtering are chemically homogenous. The film roughness evaluated by atomic force spectroscopy (AFM) on the TNTZ-Cu 8.3 at.% Cu sample presented an RMS-value of 20.1 nm being the highest RMS of any Cu-sputtered TNTZ sample. The implication of the RMS value found for this sample leading to the fastest interfacial bacterial inactivation kinetics is also discussed. Values for the Young's modulus and hardness are reported for the TNTZ films in the presence of various Cu-contents. Evaluation of the bacterial inactivation kinetics of E. coli under low intensity actinic hospital light and in the dark was carried out. The stable repetitive bacterial inactivation was consistent with the extremely low Cu-ion release from the samples of 0.4 ppb. Evidence is presented by the bacterial inactivation dependence on the applied light intensity for the intervention of Cu as semiconductor CuO during the bacterial inactivation at the TNTZ-Cu interface. The mechanism of CuO-intervention under light is suggested based on the pH/and potential changes registered during bacterial disinfection.

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Sputtered Gum metal thin films showing bacterial inactivation and biocompatibility

Cited by 12 publications

References 29 publications

Innovative Ti_1–xNb_xN–Ag Films Inducing Bacterial Disinfection by Visible Light/Thermal Treatment

Innovative Ti_1–xNb_xN–Ag Films Inducing Bacterial Disinfection by Visible Light/Thermal Treatment

Architectured Cu–TNTZ Bilayered Coatings Showing Bacterial Inactivation under Indoor Light and Controllable Copper Release: Effect of the Microstructure on Copper Diffusion

Beneficial effect of Cu on Ti-Nb-Ta-Zr sputtered uniform/adhesive gum films accelerating bacterial inactivation under indoor visible light

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Sputtered Gum metal thin films showing bacterial inactivation and biocompatibility

Cited by 12 publications

References 29 publications

Innovative Ti1–xNbxN–Ag Films Inducing Bacterial Disinfection by Visible Light/Thermal Treatment

Innovative Ti1–xNbxN–Ag Films Inducing Bacterial Disinfection by Visible Light/Thermal Treatment

Architectured Cu–TNTZ Bilayered Coatings Showing Bacterial Inactivation under Indoor Light and Controllable Copper Release: Effect of the Microstructure on Copper Diffusion

Beneficial effect of Cu on Ti-Nb-Ta-Zr sputtered uniform/adhesive gum films accelerating bacterial inactivation under indoor visible light

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Product

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Innovative Ti_1–xNb_xN–Ag Films Inducing Bacterial Disinfection by Visible Light/Thermal Treatment

Innovative Ti_1–xNb_xN–Ag Films Inducing Bacterial Disinfection by Visible Light/Thermal Treatment