Spurious Macrocytosis, A Common Clue to Erythrocyte Cold Agglutinins

Bessman, J. David; Banks, D C

doi:10.1093/ajcp/74.6.797

Cited by 33 publications

(14 citation statements)

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“…Both of these findings reverse after the blood sample is incubated at 37°C for 20 min and are reanalyzed. 10,13 In addition to the red cell cytograms presented in this study, those with intermediate or indeterminate patterns are also seen in daily practice. An attempt must be made to optimally use the ones pointing to a particular hematological condition while maintaining a database of others for pattern matching.…”

Section: Labmedicinecommentioning

confidence: 68%

Red Cell Cytograms Generated by an ADVIA 120 Automated Hematology Analyzer: Characteristic Patterns in Common Hematological Conditions

Kakkar¹,

Makkar²

2009

Lab Med

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Worldwide, most hematology laboratories have now changed over from the labor intensive manual methods of testing to 3-or 5-part differential automated hematology analyzers. Although laboratory personnel and hematopathologists handling the automated data are familiar with the basic interpretation and benefits of numerical data, the seemingly complex graphical representation of the red cell data in the form of histograms and cytograms is often ignored. At times, these can provide vital information that may not even be apparent in the automated numerical data. 1 Characteristic red cell cytogram patterns indicative of common hematological conditions are being presented in this paper. Materials and MethodsThis study presents a compilation of characteristic red cell cytograms generated by Advia-120 (Siemens Healthcare Diagnostics, Deerfield, IL), 2 a 5-part differential system (Technicon H1 series) used in the hematology laboratory of a tertiary care teaching institution. The cytograms have been compiled over a 2-year period from blood samples (approximately 200 per day) received for routine complete blood counts (CBC) in the laboratory. Approximately 140,000 cytograms have been analyzed during the study period. Single test requests were not run through the Advia-120 and were done manually. Dipotassium ethylenediaminetetra-aceticacid (EDTA) blood was used for testing and the tubes for sample collection were prepared in-house. AbstractBackground: Graphical data output from automated hematology analyzers, especially those related to red blood cells, have been traditionally ignored in favor of the more frequently used numerical values. This study presents characteristic red cell cytograms generated by Advia-120, a 5-part automated hematology analyzer, as seen in common hematological conditions.

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Section: Labmedicinecommentioning

confidence: 68%

Red Cell Cytograms Generated by an ADVIA 120 Automated Hematology Analyzer: Characteristic Patterns in Common Hematological Conditions

Kakkar¹,

Makkar²

2009

Lab Med

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“…[12] Cold agglutinins make RBCs clump, making them appear larger to automatic cell counters. [13] Non Hodgkin Lymphomas may be associated with cold agglutinins resulting in spurious macrocytosis. [14] Weiss and Bessman reports two patients with warm autoimmune HA whose MCV values where spuriously high.…”

Section: Discussionmentioning

confidence: 99%

105 Cases of Macrocytosis- Etiologic Profile Reflecting Lifestyle Changes

Moothiringode¹

2016

jmscr

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“…Similarly, in our clinical observations, a decrease in rates of relapse could not be shown in cases in whom mucositis which is a side effect of methotrexate had a severe prognosis. Recently, White et al (11) investigated if increased MCV was a marker for hematologic toxicity in patients receiving methotrexate treatment with a diagnosis of rheumatic arthritis, but they could not find a relation . In another study, the relation of MCV values with cytogenetic response and prognosis was investigated in patients with a diagnosis of chronic myeloid leukemia receiving imatinib treatment (13).…”

Section: Discussionmentioning

confidence: 99%

Çocukluk çağı akut lenfoblastik lösemisinde tedavinin ortalama eritrosit hacimleri üzerine etkisi

Çelkan¹,

Özdemir²,

Bilgi³

et al. 2011

tpa

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T Th he e e ef ff fe ec ct t o of f t tr re ea at tm me en nt t o of f a ac cu ut te e l ly ym mp ph ho ob bl la as st ti ic c l le eu uk ke em mi ia a o on n m me ea an n e er ry yt th hr ro oy yt te e v vo ol lu um me e i in n c ch hi il ld dr re en n T Ti ir ra aj je e C Ce el lk ka an n, , N Ni ih ha al l Ö Öz zd de em mi ir r , , Z Ze ek ke er ri iy ya a Material and Method:One hundred-twenty-five children with ALL were included in this retrospective study. The MCV values of the patients (age 1-15 years, 83 boys, 42 girls) at diagnosis, at induction/consolidation chemotherapy and after maintenance treatment were evaluated. Results:The MCV values of the patients at diagnosis, at induction/consolidation chemotherapy and after maintenance treatment were 78,5+3,9 fl; 89,1+6,8 fl and 95,6+3,8 fl, respectively. On follow-up, MCV values were found to decrease with a mean of 1 fl per month after chemotherapy. The results of 15 relapsed patients were compared with results of 110 patients without relapse; there was no statistically significant difference in MCV values ( p>0.05).Conclusions: MCV was not found to be a significant parameter in relation to prognosis and relapse in children with ALL.

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Spurious Macrocytosis, A Common Clue to Erythrocyte Cold Agglutinins

Cited by 33 publications

References 0 publications

Red Cell Cytograms Generated by an ADVIA 120 Automated Hematology Analyzer: Characteristic Patterns in Common Hematological Conditions

Red Cell Cytograms Generated by an ADVIA 120 Automated Hematology Analyzer: Characteristic Patterns in Common Hematological Conditions

105 Cases of Macrocytosis- Etiologic Profile Reflecting Lifestyle Changes

Çocukluk çağı akut lenfoblastik lösemisinde tedavinin ortalama eritrosit hacimleri üzerine etkisi

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