Spur-Cell Anemia

Keyserling, Kaleb; Koprowski, Steven

doi:10.1056/nejmicm1714572

Cited by 3 publications

(2 citation statements)

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“…Vassiliadis et al reported a 25-day median survival rate in the 9 patients with SCA, and only one patient, who had undergone liver transplantation, had survived after 1 year [12]. To our knowledge, there have been 24 case reports on 26 patients with SCA since 1983 including our case (Table 3) [13,14,16,19,20,[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40]. On reviewing these cases, the average age was 42.6 years old, and 14 (53.8%) of the 26 patients were men.…”

Section: Discussionmentioning

confidence: 66%

Spur cell anemia related to alcoholic liver cirrhosis managed without liver transplantation: a case report and literature review

Miwa

Hatano

Kochi

et al. 2020

Clin J Gastroenterol

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Spur cell anemia is an acquired hemolytic anemia associated with liver cirrhosis and is characterized by the presence of increased large red blood cells, which are covered with spike-like projections that vary in width, length, and distribution. A 26-year-old man was referred to our hospital presenting with jaundice, lower limb edema, and dyspnea. The patient was subsequently diagnosed with spur cell anemia related to alcoholic liver cirrhosis. Spur cell anemia is an independent predictor of mortality in liver cirrhosis and has been associated with extremely poor prognosis. The most effective treatment for spur cell anemia is liver transplantation. As seen in the literature, the treatment of spur cell anemia without liver transplantation is quite challenging. This report highlights the importance of management and treatment strategies, including control of fluid retention, blood transfusion, plasma diafiltration, and administration of diuretics. Our treatment strategies might be useful in patients who are not candidate of liver transplantation or patients waiting for liver transplantation.

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Section: Discussionmentioning

confidence: 66%

Spur cell anemia related to alcoholic liver cirrhosis managed without liver transplantation: a case report and literature review

Miwa

Hatano

Kochi

et al. 2020

Clin J Gastroenterol

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“…[1] Spur cells are the severe form of acanthocytes that have many irregular thorn-like projections formed because of a decreased ratio of phospholipids to cholesterol in red blood cell membranes and have been furthermore altered by an enlarged spleen. [2,3] Hemolysis due to a consequence of changes to red blood cell membranes leading to spur cell formation carries an abysmal prognosis as it generally reflects end-stage liver disease. [4][5][6]…”

Section: Introductionmentioning

confidence: 99%

Rare cause of non-immune hemolytic anemia in end-stage liver disease

Sangha

Aggarwal

Sandhu

2020

CRIM

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Spur cells are reportedly linked to advanced end-stage liver diseases and may lead to accelerated hemolysis. In this case report, we discuss one of these rare instances when a 45-year-old female with decompensated cirrhosis was admitted for severe anemia. Extensive workup revealed non-immune hemolysis secondary to spur cell formation. Orthotopic liver transplantation remains the only treatment of choice for reversal of spur cell anemia. Alternatively, multidrug therapy has also been explored, including usage of bile acid sequestrants; however, success is rare.

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