Abstract:Sprouty proteins are widely accepted modulators of receptor tyrosine kinase-associated pathways and fulfill diversified roles in cancerogenesis dependent on the originating cells. In this study we detected a high expression of Sprouty3 in osteosarcoma-derived cells and addressed the question of whether Sprouty3 and Sprouty1 influence the malignant phenotype of this bone tumor entity. By using adenoviruses, the Sprouty proteins were expressed in two different cell lines and their influence on cellular behavior … Show more
“…Sprouty proteins are modulators of receptor-tyrosine-kinase-induced signal transmission. The work of Kamptner et al investigates the function of Sprouty1 and Sprouty3 in osteosarcoma-derived cells [ 6 ]. The experiments described therein show that Sprouty1 has no significant effect on the biological processes involved in malignancies such as proliferation, migration, or spheroid formation, whereas the ectopic expression of Sprouty3 promotes all three processes.…”
Higher organisms, such as humans, are made up of trillions of cells that have to act as a unit in a finely tuned way to ensure the functioning of the living being that is composed of them [...]
“…Sprouty proteins are modulators of receptor-tyrosine-kinase-induced signal transmission. The work of Kamptner et al investigates the function of Sprouty1 and Sprouty3 in osteosarcoma-derived cells [ 6 ]. The experiments described therein show that Sprouty1 has no significant effect on the biological processes involved in malignancies such as proliferation, migration, or spheroid formation, whereas the ectopic expression of Sprouty3 promotes all three processes.…”
Higher organisms, such as humans, are made up of trillions of cells that have to act as a unit in a finely tuned way to ensure the functioning of the living being that is composed of them [...]
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