Spreadsheet-based nonlinear analysis of in vitro release properties of a model drug from colloidal carriers

Juhász, Ádám; Ungor, Ditta; Berta, Katalin; Serés, L.; Csapó, Edit

doi:10.1016/j.molliq.2021.115405

Cited by 22 publications

(16 citation statements)

References 45 publications

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“…To analyze the primer release data, the dissolution profiles were fitted by a non-linear technique using seven different kinetic models applying a self-developed and freely available routine [ 26 ], which was published previously by our research group. First- and second-order [ 27 , 28 ], Higuchi [ 29 ], Weibull [ 30 ], Korsmeyer–Peppas [ 31 ], Hopfenberg [ 32 ] and Hixon-Crowell [ 20 , 33 ] models were tested, where models take different physicochemical parameters into account.…”

Section: Resultsmentioning

confidence: 99%

“…For the mathematical description of the in vitro dissolution, seven different kinetic models were chosen, which are the first- [ 27 ] and second-order [ 28 ], Higuchi [ 29 ], Weibull [ 30 ], Korsmeyer–Peppas [ 31 ], Hopfenberg [ 32 ] and Hixon–Crowell [ 33 , 38 ] models. The calculation was executed based on a previously published open access spreadsheet method [ 26 ] by nonlinear fitting. The goodness of the fits was determined by the value of R 2 .…”

Section: Methodsmentioning

confidence: 99%

“…able routine [26], which was published previously by our research group. First-and sec-ond-order [27,28], Higuchi [29], Weibull [30], Korsmeyer-Peppas [31], Hopfenberg [32] and Hixon-Crowell [20,33] models were tested, where models take different physicochemical parameters into account.…”

Section: Analysis Of the Ph-dependent Vitamin Release From Lipsmentioning

confidence: 99%

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The pH-Dependent Controlled Release of Encapsulated Vitamin B1 from Liposomal Nanocarrier

Juhász

Ungor

Várkonyi

et al. 2021

IJMS

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In this work, we firstly presented a simple encapsulation method to prepare thiamine hydrochloride (vitamin B1)-loaded asolectin-based liposomes with average hydrodynamic diameter of ca. 225 and 245 nm under physiological and acidic conditions, respectively. In addition to the optimization of the sonication and magnetic stirring times used for size regulation, the effect of the concentrations of both asolectin carrier and initial vitamin B1 on the entrapment efficiency (EE %) was also investigated. Thermoanalytical measurements clearly demonstrated that after the successful encapsulation, only weak interactions were discovered between the carriers and the drug molecules. Moreover, the dissolution profiles under physiological (pH = 7.40) and gastric conditions (pH = 1.50) were also registered and the release profiles of our liposomal B1 system were compared with the dissolution profile of the pure drug solution and a manufactured tablet containing thiamin hydrochloride as active ingredient. The release curves were evaluated by nonlinear fitting of six different kinetic models. The best goodness of fit, where the correlation coefficients in the case of all three systems were larger than 0.98, was reached by application of the well-known second-order kinetic model. Based on the evaluation, it was estimated that our liposomal nanocarrier system shows 4.5-fold and 1.5-fold larger drug retention compared to the unpackaged vitamin B1 under physiological conditions and in artificial gastric juice, respectively.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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The pH-Dependent Controlled Release of Encapsulated Vitamin B1 from Liposomal Nanocarrier

Juhász

Ungor

Várkonyi

et al. 2021

IJMS

Self Cite

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“…The in vitro releasing experiment was conducted, using the method as reported with little modification. 53 First, 50 mg of differently prepared SK@MS was suspended in vials filled with 5 mL of PBS buffer (37°C, pH = 7.4) with a constant shaking speed of 100 rpm (Clifton Shaking Bath NE5, Nikel Electro Ltd., Weston-super-Mare, UK). At predetermined time intervals, 0.5 mL of the samples were taken out (equivalent amount of fresh PBS was used to refill) and centrifuged at 12,000 rpm for 5 min.…”

Section: Methodsmentioning

confidence: 99%

The Anti-Inflammation and Anti-Nociception Effect of Ketoprofen in Rats Could Be Strengthened Through Co-Delivery of a H2S Donor, S-Propargyl-Cysteine

Yu¹,

Yang²,

Wang³

et al. 2021

JIR

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“…The in vitro releasing experiment was conducted, using the method as reported with little modification [43]. First, 50 mg of differently prepared SPRC@PLA was dispersed in vials filled with 3 mL of PBS buffer (pH = 7.4, 37 • C) and placed in a shaker bath with a constant shaking speed of 100 rpm and temperature at 37 • C (Clifton Shaking Bath NE5, Nikel Electro Ltd., Weston-super-Mare, UK).…”

Section: The Sprc Release In Vitromentioning

confidence: 99%

The Preparation of a Novel Poly(Lactic Acid)-Based Sustained H2S Releasing Microsphere for Rheumatoid Arthritis Alleviation

Wang

Ding

et al. 2021

Pharmaceutics

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Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease that mainly erodes joints and surrounding tissues, and if it is not treated in time, it can cause joint deformities and loss of function. S-propargyl-cysteine (SPRC) is an excellent endogenous hydrogen sulfide donor which can relieve the symptoms of RA through the promotion of H2S release via the CSE/H2S pathway in vivo. However, the instant release of H2S in vivo could potentially limit its further clinical use. To solve this problem, in this study, a SPRC-loaded poly(lactic acid) (PLA) microsphere (SPRC@PLA) was prepared, which could release SPRC in vitro in a sustained manner, and further promote sustained in vivo H2S release. Furthermore, its therapeutical effect on RA in rats was also studied. A spherical-like SPRC@PLA was successfully prepared with a diameter of approximately 31.61 μm, yielding rate of 50.66%, loading efficiency of 6.10% and encapsulation efficiency of 52.71%. The SPRC@PLA showed significant prolonged in vitro SPRC release, to 4 days, and additionally, an in vivo H2S release around 3 days could also be observed. In addition, a better therapeutical effect and prolonged administration interval toward RA rats was also observed in the SPRC@PLA group.

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Spreadsheet-based nonlinear analysis of in vitro release properties of a model drug from colloidal carriers

Cited by 22 publications

References 45 publications

The pH-Dependent Controlled Release of Encapsulated Vitamin B1 from Liposomal Nanocarrier

The pH-Dependent Controlled Release of Encapsulated Vitamin B1 from Liposomal Nanocarrier

The Anti-Inflammation and Anti-Nociception Effect of Ketoprofen in Rats Could Be Strengthened Through Co-Delivery of a H2S Donor, S-Propargyl-Cysteine

The Preparation of a Novel Poly(Lactic Acid)-Based Sustained H2S Releasing Microsphere for Rheumatoid Arthritis Alleviation

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