Spreading Senescent Cells’ Burden and Emerging Therapeutic Targets for Frailty
Serena Marcozzi,
Giorgia Bigossi,
Maria Elisa Giuliani
et al.
Abstract:The spreading of senescent cells’ burden holds profound implications for frailty, prompting the exploration of novel therapeutic targets. In this perspective review, we delve into the intricate mechanisms underlying senescent cell spreading, its implications for frailty, and its therapeutic development. We have focused our attention on the emerging age-related biological factors, such as microbiome and virome alterations, elucidating their significant contribution to the loss of control over the accumulation r… Show more
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