Spreading depolarizations exhaust neuronal ATP in a model of cerebral ischemia
Karl Schoknecht,
Felipe Baeza-Lehnert,
Johannes Hirrlinger
et al.
Abstract:Spreading depolarizations (SDs) have been identified in various brain pathologies. SDs increase the cerebral energy demand and, concomitantly, oxygen consumption, which indicates enhanced synthesis of adenosine triphosphate (ATP) by oxidative phosphorylation. Therefore, SDs are considered particularly detrimental during reduced supply of oxygen and glucose. However, measurements of intracellular neuronal ATP ([ATP]i), ultimately reporting the balance of ATP synthesis and consumption during SDs, have not yet be… Show more
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