Spreading by Implantation on Epithelial Surfaces and Iatrogenic Spreading by Implantation

Kaiser, Hans E.

doi:10.1007/978-94-009-1093-5_4

Cited by 1 publication

(6 citation statements)

References 28 publications

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“…However, clinical evidence of this proposition is lacking. 1,2,6,[9][10][11][12][13][14][15] For the first time, this study provides the scientific proof for the presence of ET cells in oncological surgery resection. It also suggests potential routes of ET cells spillage.…”

Section: Information and Characteristics Of Positive Et Cells Cases Arementioning

confidence: 56%

“…Despite the significant impact of oncology surgery on patients’ survival, it was already noted in the early twentieth century that surgical manipulation might promote tumour outgrowth. Because of their loose microarchitecture and low cohesiveness, these dislodged neoplastic fragments may transmit to various epithelial surfaces and lead to metastasis 2 . However, the principles behind are still poorly understood.…”

Section: Introductionmentioning

confidence: 99%

“…However, the principles behind are still poorly understood. Up to this date, the concept of surgery‐induced tumour growth is largely based on the results from preclinical studies; clinical data to support this are lacking 2–8 …”

Section: Introductionmentioning

confidence: 99%

“…and low cohesiveness, these dislodged neoplastic fragments may transmit to various epithelial surfaces and lead to metastasis. 2 However, the principles behind are still poorly understood. Up to this date, the concept of surgery-induced tumour growth is largely based on the results from preclinical studies; clinical data to support this are lacking.…”

mentioning

confidence: 99%

“…Up to this date, the concept of surgery-induced tumour growth is largely based on the results from preclinical studies; clinical data to support this are lacking. [2][3][4][5][6][7][8] This study aimed to investigate the impact of cancer surgery per se upon tumour cells spillage. We have also investigated various potential routes of tumour cells spillage during operations.…”

mentioning

confidence: 99%

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Discovery of escapee tumour cells—a milestone in cancer surgery

Wong

Fung

et al. 2023

Surgical Practice

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BackgroundComplete excision of tumour is the basic principle of curative surgery and traditionally oncological en‐bloc tumour resection is a common practice. However, ironically, it is questionable whether surgery itself will cause tumour spillage.MethodFrom January 2019 to March 2022, 133 tumour‐related operations were performed. Routine operating field toileting was performed using warm normal saline before the end of operations. A filter was connected to the suction device throughout the whole operation processes. Sediments being trapped by the filter were sent for histopathology to look for the presence of spillage tumour cells—escapee tumour (ET) cells.ResultsA total of 26 (19.5%) of the collected residue showed the presence of ET cells while 16 residue samples (12%) revealed the presence of atypical cells. Incomplete resection (R1, R2 resection; P = .005, B = 1.519), advanced N‐stage (N2 or N3 disease; P = .031, B = 1.510) and certain cancer type (oesophageal cancer in this study; P = .027, B = −1.567) are the statistically significant factors related to the presence of ET cells.ConclusionTumour spillage occurs during operations. Long‐term follow‐up and larger‐scale studies are required to determine the clinical significance of the positive ET cell cases and how to prevent tumour spillage during operations in the future.

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