Spread of Escherichia coli colonizing newborn babies and their mothers

Bettelheim, K. A.; Teoh-Chan, C. H.; Chandler, Mary E.; O'Farrell, S; Rahamim, Layla; Shaw, Elizabeth; Shooter, R. A.

doi:10.1017/s002217240004273x

Cited by 35 publications

(10 citation statements)

References 5 publications

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“…Results of the control samples were found similar to previous stud ies for: date of bowel colonization, frequency of drug resistance and relative stability of the flora [2,3,15,21]. Enterobacteria were present in the first stools of 53 children out of 60 at a mean level of 9.0 (s = 0.1); drug-resis tant enterobacteria were present in the first stools of 48 children at a mean level of 8.3 (s = 0.2); the dominant enterobacteria were drug-resistant in the first stools of 31 chil dren; drug-resistant enterobacteria reached at least level 7 in 44 children.…”

Section: General Considerationssupporting

confidence: 83%

“…They were admitted to the intensive-care unit of the Pediatric Hospital of Tours (France) on the day of delivery or the day after. They were chosen for (1) presenting no digestive trouble, (2) having no need of any antibiotic and having re ceived none, and (3) being born from mothers who had not received any antibiotic during or after preg nancy. They were all fed with human milk provided by the lactarium (40/60) or with an artificial one (20/60) by bottle or by gastric-tube feeding.…”

Section: Methodsmentioning

confidence: 99%

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Evolution of the Barrier Effects against an Exogenous Drug-Sensitive Escherichia coli Strain after Single or Repeated Oral Administration to Newborns and Infants Aged up to Three Months Admitted to an Intensive-Care Unit

Poisson¹,

Borderon²,

Amorim-Sena³

et al. 1986

Neonatology

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60 neonates – 42 newborns 0–30 days old and 18 infants 31–90 days old -without previous antibiotic treatment were chosen and randomized into three groups (A, B, C). The strain of Escherichia coli administered was antibiotic-sensitive and azide-resistant (E. coli AZ). The digestive implantation was quantified by an index. We studied the variations of this index (1) between the single administration group (A) and the 5 administrations group (B) and (2) with age in both groups. Drug-resistant enterobacteria were also numbered in each stool, and their variations were studied by comparing groups A and B to a control group (C) receiving no administration. Multiple administrations did not lead to different results from the single ones. Age played a negative role in the colonizations after single administration, but a positive one after multiple administrations. Drug-resistant enterobacteria were not affected by any procedure. The drug susceptibility of E. coli AZ was lost in only 1 infant.

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Section: General Considerationssupporting

confidence: 83%

Section: Methodsmentioning

confidence: 99%

Evolution of the Barrier Effects against an Exogenous Drug-Sensitive Escherichia coli Strain after Single or Repeated Oral Administration to Newborns and Infants Aged up to Three Months Admitted to an Intensive-Care Unit

Poisson¹,

Borderon²,

Amorim-Sena³

et al. 1986

Neonatology

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“…Strains spread in the hospital milieu contributed significantly to colonization (29). In developing countries, almost all infants acquire E. coli in the first week of life (30,31), including infants delivered by cesarean section (31,32) In the present study, we noted less than 50% E. coli colonization by 1 wk of age.…”

Section: Discussionsupporting

confidence: 42%

Escherichia coli in Infants' Intestinal Microflora: Colonization Rate, Strain Turnover, and Virulence Gene Carriage

et al. 2003

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Colonization by Escherichia. coli in infants might have decreased in the last decades, owing to changes in hospital routines and family lifestyle. In this study, the E. coli flora was characterized in 70 healthy Swedish infants followed for the first year of life. E. coli was isolated from rectal swabs obtained at 3 d of age and quantified in fecal samples collected at 1, 2, 4, and 8 wk of age and at 6 and 12 mo of age. Strains were typed using random amplified polymorphic DNA, and their virulence factor genes were identified by multiplex PCR. Colonization by E. coli occurred late; only 61% of the infants were positive by 2 mo of age. The turnover of individual strains in the microflora was slow (1.5 strains per infant during 6 mo, 2.1 during 1 y). Environmental factors, such as siblings, pets, or feeding mode, did not influence colonization kinetics or strain turnover rate. Genes encoding type 1 fimbriae, P fimbriae, and hemolysin were significantly more common in E. coli strains persisting for at least 3 wk in the microflora than in transient strains. The P-fimbrial class III adhesin gene was more common in E. coli from children who had a cat in their homes than in E. coli from children without pets (p ϭ 0.01); this adhesin type is common in E. coli from cats. The late colonization and low E. coli strain turnover rate suggest limited exposure of Swedish infants to E. coli. Our results confirm that P fimbriae and other virulence factors facilitate persistence of E. coli in the human colonic microflora. Escherichia coli is one of the first bacterial species to colonize the infant's intestines. In the 1970s, E. coli usually appeared in the baby's feces a few days after birth (1, 2), as a sign of its establishment in the intestinal microflora (3, 4). E. coli colonizing the newborn infant may originate in the maternal fecal flora (5), but E. coli strains are also commonly spread at maternity wards via the nursing staff, especially during periods of high bed-occupancy and staff workload (6). We have recently reported that Staphylococcus aureus has become a major colonizer of the infant gut (7), which may be a sign of reduced competition from other microbes. E. coli and other fecal bacteria might be less easily spread today, because of increased hygiene in hospitals and families.Some E. coli strains persist in the intestinal microflora of an individual for months or years (resident strains), whereas others (transient strains) disappear within a few weeks (8). Resident E. coli strains display certain characteristics that enable them to persist in the intestinal microflora, e.g. the expression of P fimbriae and capacity to adhere to colonic epithelial cells (9 -12). P fimbriae are composed of a fimbrial rod with a tip adhesin that exists in three varieties, termed papG classes I, II, and III. These recognize the Gal␣134Gal␤ disaccharide, with slight differences in binding specificity (13). The class II variety of the papG adhesin is common among E. coli causing pyelonephritis (14), whereas the class III variety is comm...

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“…Domesticated animals are a potential source of human infections, and contamination of food by Escherichia coli from animals is widespread [1,2]. Analysis of the serotypes of human and animal E. coli strains from diarrheal diseases have indicated that they are distinct in most cases [3,4]. However, few studies show that there are E. coil clones which are pathogenic for both humans and animals.…”

Section: Introductionmentioning

confidence: 99%

Clonal relationships among Escherichia coli serogroup 06 isolates from human and animal infections

Cherifi

1991

FEMS Microbiology Letters

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The clonal relationship of thirty E. coli strains of 0 antigen serotype 06 isolated from human, dog, pig or cow infections were investigated. Two main clones with serotypes 06 : H1 or 06 : H31, H- were identified. Isolates from humans, dogs, pigs and cows were found in both clones, indicating that animals are a possible source for human extraintestinal Escherichia coli strains. Two human ETEC (06 : H16) and two pig isolates (06 : H10) were not related to the 06 : H1 or 06 : H31, H- E. coli clones.

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Spread of Escherichia coli colonizing newborn babies and their mothers

Cited by 35 publications

References 5 publications

Evolution of the Barrier Effects against an Exogenous Drug-Sensitive <i>Escherichia coli</i> Strain after Single or Repeated Oral Administration to Newborns and Infants Aged up to Three Months Admitted to an Intensive-Care Unit

Evolution of the Barrier Effects against an Exogenous Drug-Sensitive <i>Escherichia coli</i> Strain after Single or Repeated Oral Administration to Newborns and Infants Aged up to Three Months Admitted to an Intensive-Care Unit

Escherichia coli in Infants' Intestinal Microflora: Colonization Rate, Strain Turnover, and Virulence Gene Carriage

Clonal relationships among Escherichia coli serogroup 06 isolates from human and animal infections

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