Spread of excitation varies for different electrical pulse shapes and stimulation modes in cochlear implants

Undurraga, Jaime A.; Carlyon, Robert P.; Macherey, Olivier; Wouters, Jan; Wieringen, Astrid Van

doi:10.1016/j.heares.2012.05.003

Cited by 36 publications

(52 citation statements)

References 42 publications

(62 reference statements)

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“…For example, in BP stimulation, two main groups of neurons may be excited, close to each stimulated electrode. Such dual-peak excitation patterns have also been reported in an electrophysiological animal study (Snyder et al, 2008) and in psychophysical and electrophysiological human CI studies (Lim et al, 1989;Chatterjee et al, 2006;Undurraga et al, 2012). This dual-peak shape may also arise when measuring tuning curves.…”

Section: Introductionsupporting

confidence: 59%

Simulating the dual-peak excitation pattern produced by bipolar stimulation of a cochlear implant: Effects on speech intelligibility

Mesnildrey

Macherey

2015

Hearing Research

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Section: Introductionsupporting

confidence: 59%

Simulating the dual-peak excitation pattern produced by bipolar stimulation of a cochlear implant: Effects on speech intelligibility

Mesnildrey

Macherey

2015

Hearing Research

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“…Contrary to most data obtained from animal and computer models (Frijns et al 1996;Miller et al 1997Miller et al , 1998Miller et al , 1999bMiller et al , 2001Klop et al 2004;Smit et al 2010), objective and behavioral data from CI users suggest that the anodic polarity is more effective than the cathodic one 2008Undurraga et al 2010Undurraga et al , 2012. However, there are several issues that shall be taken into account from those studies.…”

Section: Introductionmentioning

confidence: 87%

“…Previous studies have demonstrated that human ECAP responses with asymmetric and SYM stimuli with a long IPG could be obtained when the effective phase of the stimuli was anodic (Macherey et al 2008;Undurraga et al 2010Undurraga et al , 2012.…”

Section: Ecap and Eabrmentioning

confidence: 99%

“…Evidence consistent with the idea that CI listeners are insensitive to cathodic stimulation comes from measures of the electrically evoked compound action potential (ECAP). Those studies, which used the masker-probe paradigm (Macherey et al 2008;Undurraga et al 2010Undurraga et al , 2012, found evidence for activation only by the anodic phase of asymmetric pulses.…”

Section: Introductionmentioning

confidence: 99%

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The Polarity Sensitivity of the Electrically Stimulated Human Auditory Nerve Measured at the Level of the Brainstem

Undurraga

Carlyon

Wouters

et al. 2013

JARO

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Recent behavioral studies have suggested that the human auditory nerve of cochlear implant (CI) users is mainly excited by the positive (anodic) polarity. Those findings were only obtained using asymmetric pseudomonophasic (PS) pulses where the effect of one phase was measured in the presence of a counteracting phase of opposite polarity, longer duration, and lower amplitude than the former phase. It was assumed that only the short high-amplitude phase was responsible for the excitation. Similarly, it has been shown that electrically evoked compound action potentials could only be obtained in response to the anodic phases of asymmetric pulses. Here, experiment 1 measured electrically evoked auditory brainstem responses to standard symmetric, PS, reversed pseudomonophasic, and reversed pseudomonophasic with inter-phase gap (6 ms) pulses presented for both polarities. Responses were time locked to the short high-amplitude phase of asymmetric pulses and were smaller, but still measurable, when that phase was cathodic than when it was anodic. This provides the first evidence that cathodic stimulation can excite the auditory system of human CI listeners and confirms that this stimulation is nevertheless less effective than for the anodic polarity. A second experiment studied the polarity sensitivity at different intensities by means of a loudness balancing task between pseudomonophasic anodic (PSA) and pseudomonophasic cathodic (PSC) stimuli. Previous studies had demonstrated greater sensitivity to anodic stimulation only for stimuli producing loud percepts. The results showed that PSC stimuli required higher amplitudes than PSA stimuli to reach the same loudness and that this held for current levels ranging from 10 to 100 % of the dynamic range.

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“…As Rosenthal's canal is not linearly related to the organ of Corti [Kawano et al, 1996] it is unclear which frequency-position function is appropriate for intracochlear electrical stimulation [Greenwood, 1990;Sridhar et al, 2006;Stakhovskaya et al, 2007;Schatzer et al, 2014]. Finally, mechanisms like spread of excitation [Hughes et al, 2013] including cross-turn stimulation [Frijns et al, 2001;Boëx et al, 2006] and channel interaction [Abbas et al, 2004;Undurraga et al, 2012] and frequency-place map reorganization Reiss et al, 2014] may influence the frequency-position prediction, and may thus affect which electrode is the tinnitus pitch-matched electrode.…”

Section: Effect Of Stimulation Sitementioning

confidence: 99%

Tinnitus Suppression by Intracochlear Electrical Stimulation in Single-Sided Deafness: A Prospective Clinical Trial - Part I

et al. 2015

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Cochlear implantation is a viable treatment option for tinnitus, but the underlying mechanism is yet unclear. Is the tinnitus suppression due to the reversal of the assumed maladaptive neuroplasticity or is it the shift in attention from the tinnitus to environmental sounds and therefore a reduced awareness that reduces tinnitus perception? In this prospective trial, 10 patients with single-sided deafness were fitted with a cochlear implant to investigate the effect of looped intracochlear electrical stimulation (i.e. stimulation that does not encode environmental sounds) on tinnitus, in an effort to find optimal stimulation parameters. Variables under investigation were: amplitude (perceived stimulus loudness), anatomical location inside the cochlea (electrode/electrodes), amplitude modulation, polarity (cathodic/anodic first biphasic stimulation) and stimulation rate. The results suggest that tinnitus can be reduced with looped electrical stimulation, in some cases even with inaudible stimuli. The optimal stimuli for tinnitus suppression appear to be subject specific. However, medium-to-loud stimuli suppress tinnitus significantly better than soft stimuli, which partly can be explained by the masking effect. Although the long-term effects on tinnitus would still have to be investigated and will be described in part II, intracochlear electrical stimulation seems a potential treatment option for tinnitus in this population.

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Spread of excitation varies for different electrical pulse shapes and stimulation modes in cochlear implants

Cited by 36 publications

References 42 publications

Simulating the dual-peak excitation pattern produced by bipolar stimulation of a cochlear implant: Effects on speech intelligibility

Simulating the dual-peak excitation pattern produced by bipolar stimulation of a cochlear implant: Effects on speech intelligibility

The Polarity Sensitivity of the Electrically Stimulated Human Auditory Nerve Measured at the Level of the Brainstem

Tinnitus Suppression by Intracochlear Electrical Stimulation in Single-Sided Deafness: A Prospective Clinical Trial - Part I

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