Sprayed in-situ synthesis of polyvinyl alcohol/chitosan loaded silver nanocomposite hydrogel for improved antibacterial effects

Kumar, Arun; Kaur, Harman

doi:10.1016/j.ijbiomac.2019.09.186

Cited by 43 publications

(22 citation statements)

References 67 publications

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“…Therefore, chitosan is widely used in drug delivery due to its technological properties, which allow us to process the polymer in different ways (Table 5). [190,191] Nanocomposites [192,193] Composites [194] Initially, a chitosan salt (chitosan hydrochloride) was approved in 2002 by the Pharmacopeia. Chitosan was first introduced as an excipient into the European Pharmacopeia 6.0 and the 29th edition of the United States Pharmacopeia (USP) 34-NF almost ten years later.…”

Section: Chitosan In Drug Deliverymentioning

confidence: 99%

Chitosan: An Overview of Its Properties and Applications

et al. 2021

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Chitosan has garnered much interest due to its properties and possible applications. Every year the number of publications and patents based on this polymer increase. Chitosan exhibits poor solubility in neutral and basic media, limiting its use in such conditions. Another serious obstacle is directly related to its natural origin. Chitosan is not a single polymer with a defined structure but a family of molecules with differences in their composition, size, and monomer distribution. These properties have a fundamental effect on the biological and technological performance of the polymer. Moreover, some of the biological properties claimed are discrete. In this review, we discuss how chitosan chemistry can solve the problems related to its poor solubility and can boost the polymer properties. We focus on some of the main biological properties of chitosan and the relationship with the physicochemical properties of the polymer. Then, we review two polymer applications related to green processes: the use of chitosan in the green synthesis of metallic nanoparticles and its use as support for biocatalysts. Finally, we briefly describe how making use of the technological properties of chitosan makes it possible to develop a variety of systems for drug delivery.

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Section: Chitosan In Drug Deliverymentioning

confidence: 99%

Chitosan: An Overview of Its Properties and Applications

et al. 2021

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“…ity [30], low toxicity [24,[31][32][33], good strength [34,35], and high water content [36][37][38]. Currently, the PVA-based materials are extensively utilized in the medical, industrial, and agricultural industries [39].…”

Section: Abstract a R T I C L E I N F O R M A T I O Nmentioning

confidence: 99%

A review of Polyvinyl alcohol / Carboxiy methyl cellulose (PVA/CMC) composites for various applications

khoramabadi

Arefian

Hojjati

et al. 2020

jcc

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Polyvinyl alcohol/carboxymethyl cellulose (PVA/CMC) composites have attracted considerable attention due to the synergic relation between the two polymers and developing novel blends with improved properties. On one hand, PVA is a versatile polymer with higher mechanical properties compared to CMC. On the other hand, CMC has high biodegradability and biocompatibility, while suffering from poor mechanical properties. Therefore, the blending of the two polymers can help to benefit from the individual component properties. This paper has reviewed the properties and potential applications (e.g. drug delivery, food packaging, and agriculture) of the PVA/ CMC composites.

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“…e wells in the microtiter plates were stained with crystal violet stain (0.4%) to determine the biofilm inhibitory effect of AgNPs using a spectrophotometer at 570 nm [19].…”

Section: Biofilm Inhibition Assaymentioning

confidence: 99%

“…e bark of the shrub is used as antivenom. Besides, this shrub was also studied for its antibacterial, antifungal, antiviral, antiallergic, antihistaminic, anticancer, immunotoxic, and ulcerogenic properties [16][17][18][19]. Recently, Betulinic acid from the leaves of N. arbor was reported for having in vitro anticancer property [20].…”

Section: Introductionmentioning

confidence: 99%

Facile and Eco-Friendly Fabrication of Silver Nanoparticles Using Nyctanthes arbor-tristis Leaf Extract to Study Antibiofilm and Anticancer Properties against Candida albicans

Shafreen

Siddharthan

Velmurugan

et al. 2022

Advances in Materials Science and Engineering

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The synthesis of silver nanoparticles has been gaining more attention in recent years due to their small size and high stability. For this study, silver nanoparticles were biosynthesized from leaf extract of the medicinal plant (N. arbor-tristis). Vitally, the shrub with tremendous medicinal usage was diversely observed in South Asia and South East Asia. The synthesized silver nanoparticles were characterized by color visualization, ultraviolet-visible spectrophotometry (UV-Vis), Fourier-transform infrared spectroscopy (FTIR), field emission-scanning electron microscopy (FESEM), energy-dispersive X-ray spectroscopy (EDX), and dynamic light scattering (DLS) technique. A sharp peak at 427 nm for biosynthesized nanoparticles was obtained using UV-Vis, which represents surface plasmon resonance. Thus, characterization techniques showed the green synthesis of AgNPs leads to the fabrication of spherical shape particles with a size of 67 nm. Furthermore, AgNPs were subjected to antibiofilm studies against Candida albicans and it was observed that 0.5 μg mL−1 of AgNPs significantly reduced 50% of biofilm formation. These biosynthesized nanoparticles also showed a considerable reduction in viability of HeLa cells at 0.5 μg mL−1. The morphological changes induced by AgNPs were observed by AO/EB staining. The toxic effect of AgNPs was studied using brine shrimp as a model system. Therefore, it is envisaged that further investigation with these AgNPs can replace toxic chemicals, assist in the development of biomedical implants that can prevent biofilm formation, and avoid infections due to C. albicans.

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Sprayed in-situ synthesis of polyvinyl alcohol/chitosan loaded silver nanocomposite hydrogel for improved antibacterial effects

Cited by 43 publications

References 67 publications

Chitosan: An Overview of Its Properties and Applications

Chitosan: An Overview of Its Properties and Applications

A review of Polyvinyl alcohol / Carboxiy methyl cellulose (PVA/CMC) composites for various applications

Facile and Eco-Friendly Fabrication of Silver Nanoparticles Using Nyctanthes arbor-tristis Leaf Extract to Study Antibiofilm and Anticancer Properties against Candida albicans

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