Spray freeze drying as an alternative technique for lyophilization of polymeric and lipid-based nanoparticles

Ali, Marfoua S.; Lamprecht, Alf

doi:10.1016/j.ijpharm.2016.11.023

Cited by 50 publications

(17 citation statements)

References 34 publications

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“…On the other hand, in the spray freeze drying technique, a liquid containing the coating and core materials is sprayed into a cryogenic chamber wherein the spray droplets are rapidly frozen. Then the frozen droplets are lyophilised to take away the solvent and generate dried particles [43,45]. The various methods described below have the same aim, namely, coating living microorganisms with a protective layer.…”

Section: Methods For Microencapsulation Of Probioticsmentioning

confidence: 99%

A Brief Review of Edible Coating Materials for the Microencapsulation of Probiotics

et al. 2020

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The consumption of probiotics has been associated with a wide range of health benefits for consumers. Products containing probiotics need to have effective delivery of the microorganisms for their consumption to translate into benefits to the consumer. In the last few years, the microencapsulation of probiotic microorganisms has gained interest as a method to improve the delivery of probiotics in the host as well as extending the shelf life of probiotic-containing products. The microencapsulation of probiotics presents several aspects to be considered, such as the type of probiotic microorganisms, the methods of encapsulation, and the coating materials. The aim of this review is to present an updated overview of the most recent and common coating materials used for the microencapsulation of probiotics, as well as the involved techniques and the results of research studies, providing a useful knowledge basis to identify challenges, opportunities, and future trends around coating materials involved in the probiotic microencapsulation.

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Section: Methods For Microencapsulation Of Probioticsmentioning

confidence: 99%

A Brief Review of Edible Coating Materials for the Microencapsulation of Probiotics

et al. 2020

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“…Owing to the instability of liposomes in aqueous dispersion, there is always a need to formulate liposomes into solid dosage forms61., 62., 63., 64.. Traditionally, freeze-drying is employed to produce solid liposomal formulations with good reconstituting capacities64., 65., 66.. However, the freeze-drying technology is less efficient and consumes much time and money.…”

Section: Challenges Confronting Liposomes As Oral Drug Delivery Systemsmentioning

confidence: 99%

Adapting liposomes for oral drug delivery

Lü

et al. 2019

Acta Pharmaceutica Sinica B

455

250

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Liposomes mimic natural cell membranes and have long been investigated as drug carriers due to excellent entrapment capacity, biocompatibility and safety. Despite the success of parenteral liposomes, oral delivery of liposomes is impeded by various barriers such as instability in the gastrointestinal tract, difficulties in crossing biomembranes, and mass production problems. By modulating the compositions of the lipid bilayers and adding polymers or ligands, both the stability and permeability of liposomes can be greatly improved for oral drug delivery. This review provides an overview of the challenges and current approaches toward the oral delivery of liposomes.

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“…Bile salts, fatty acid derivatives, or surfactants increased the mucosal permeability of insulin but they concomitantly increase the risks for local irritation, nasal secretion, sneezing, or burning sensation [31,32]. Additionally, the presence of surface-active components has been reported to impede the structural integrity of SFD particles [38].…”

Section: Discussionmentioning

confidence: 99%

Spray Freeze Dried Lyospheres® for Nasal Administration of Insulin

et al. 2021

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Pharmacologically active macromolecules, such as peptides, are still a major challenge in terms of designing a delivery system for their transport across absorption barriers and at the same time provide sufficiently high long-term stability. Spray freeze dried (SFD) lyospheres® are proposed here as an alternative for the preparation of fast dissolving porous particles for nasal administration of insulin. Insulin solutions containing mannitol and polyvinylpyrrolidone complemented with permeation enhancing excipients (sodium taurocholate or cyclodextrins) were sprayed into a cooled spray tower, followed by vacuum freeze drying. Final porous particles were highly spherical and mean diameters ranged from 190 to 250 µm, depending on the excipient composition. Based on the low density, lyospheres resulted in a nasal deposition rates of 90% or higher. When tested in vivo for their glycemic potential in rats, an insulin-taurocholate combination revealed a nasal bioavailability of insulin of 7.0 ± 2.8%. A complementary study with fluorescently labeled-dextrans of various molecular weights confirmed these observations, leading to nasal absorption ranging from 0.7 ± 0.3% (70 kDa) to 10.0 ± 3.1% (4 kDa). The low density facilitated nasal administration in general, while the high porosity ensured immediate dissolution of the particles. Additionally, due to their stability, lyospheres provide an extremely promising platform for nasal peptide delivery.

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Spray freeze drying as an alternative technique for lyophilization of polymeric and lipid-based nanoparticles

Cited by 50 publications

References 34 publications

A Brief Review of Edible Coating Materials for the Microencapsulation of Probiotics

A Brief Review of Edible Coating Materials for the Microencapsulation of Probiotics

Adapting liposomes for oral drug delivery

Spray Freeze Dried Lyospheres® for Nasal Administration of Insulin

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