Spray-Drying Technology

Miller, Dave A.; Gil, Marco

doi:10.1007/978-1-4614-1144-4_10

Cited by 23 publications

(6 citation statements)

References 56 publications

(71 reference statements)

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“…Additional important solvent properties include drying efficiency, combustibility, viscosity, and toxicity 96 . The drying efficiency is governed by the extent of heat and mass transfer which in turn depends on heat supply and solvent vapor removal.…”

Section: Manufacturing Methods For Preparing Amorphous Solid Dispersionsmentioning

confidence: 99%

Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies

Bhujbal

Mitra

Jain

et al. 2021

Acta Pharmaceutica Sinica B

260

131

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Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and bioavailability of poorly water-soluble drugs. Various approaches have been employed to produce ASDs and novel techniques are emerging. This review provides an updated overview of manufacturing techniques for preparing ASDs. As physical stability is a critical quality attribute for ASD, the impact of formulation, equipment, and process variables, together with the downstream processing on physical stability of ASDs have been discussed. Selection strategies are proposed to identify suitable manufacturing methods, which may aid in the development of ASDs with satisfactory physical stability.

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Section: Manufacturing Methods For Preparing Amorphous Solid Dispersionsmentioning

confidence: 99%

Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies

Bhujbal

Mitra

Jain

et al. 2021

Acta Pharmaceutica Sinica B

260

131

View full text Add to dashboard Cite

show abstract

“…There are several literature reports demonstrating the role of solvent removal process in the development of ASD (Joe et al 2010;Miller and Gil 2010). The choice of solvent evaporation process is influenced by the scale, the stability of the formulation, and the availability of equipment.…”

Section: Selection Of Solvent Evaporation Processmentioning

confidence: 99%

Overview of Amorphous Solid Dispersion Technologies

Sandhu

Shah

Chokshi

et al. 2014

Advances in Delivery Science and Technology

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A survey of recent literature shows considerable growth in the application of amorphous solid dispersion (ASD) to solve solubility-related challenges in product development (Williams et al. , 2013Repka et al. 2013). This growth is primarily driven by three factors:a. development and expansion of acceptable excipients especially at the dose level that is needed for solid dispersion, b. application of newer technologies, and c. enhanced understanding of amorphous systems using predictive analytical tools for stability and dissolution.The earlier developments in ASD were hindered by the lack of scientific understanding of the metastable high-energy form and the availability of suitable technologies (Sekiguchi et al. 1964). For the purpose of this chapter, the processing technologies are classified into two main classes primarily, i.e., solvent based or fusion based. A schematic of this classification is shown in Fig. 3.1 to help orient the readers (Miller 2012). Based on their maturity, selected technologies are covered in this chapter with a goal to provide the necessary tools to help select an appropriate technology for a specific application.

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“…However, it shows poor emulsifying capacity and emulsion stability. Whey protein isolate can stabilize emulsion droplets during homogenization as it interacts at the water–oil interface and thus inhibits the oxidation (Gharsallaoui et al, 2007; Goula & Adamopoulos, 2012; Madene et al, 2006; Miller & Gil, 2012; Souza et al, 2018). The drying technique and the materials used as coating usually affect the retention capacity of compounds within the matrix (Rosenberg et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

Microencapsulation of phycocyanin by spray‐drying method: Effect of process parameters and wall materials

İlter

Koç

Demirel

et al. 2022

Food Processing Preservation

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Spray‐drying method was used for the microencapsulation of the extracted, purified phycocyanin from Arthrospira platensis to increase its stability and usability as a food colorant. The effect of process conditions – wall material type, ratio, and inlet‐air temperature – on physical and chemical properties was investigated. The moisture content and water activity of phycocyanin microcapsules were found as 1.80–3.18% and 0.15–0.24, respectively. The product with the largest particle size was 19.44 μm. Size distribution values were in 1.87–6.05. Optimum process condition was determined as 34.4% maltodextrin, 65.6% whey protein isolate, and 167.6°C inlet temperature. Moisture content (2.35%), aw (0.18), Tg (58.25°C), D[4,3] (11.92 μm), size distribution (2.016), color properties (L*: 79.37, a*: −6.69, b*: −5.29), total phenolic content (12.14 mgGA/L), and microencapsulation efficiency (87.11%) of the phycocyanin microcapsules were also determined at optimum. Microencapsulation efficiency increased with the maltodextrin and whey protein isolate together; the conditions of process variables were effective in the encapsulation process. Novelty impact statement Phycocyanin was prepared in a double‐layer emulsion and dried in a spray dryer, thus preventing degradation caused by environmental factors. The physical and chemical properties of the final product were examined and modeled. The conditions required to obtain the microencapsulated phycocyanin with optimum properties were examined.

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Spray-Drying Technology

Cited by 23 publications

References 56 publications

Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies

Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies

Overview of Amorphous Solid Dispersion Technologies

Microencapsulation of phycocyanin by spray‐drying method: Effect of process parameters and wall materials

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