Spray-drying of solutions containing chitosan together with polyuronans and characterisation of the microspheres

Muzzarelli, Corrado; Stanić, Vesna; Gobbi, L.; Tosi, Giorgio; Müzzarelli, Riccardo A.A.

doi:10.1016/j.carbpol.2004.04.002

Cited by 91 publications

(32 citation statements)

References 37 publications

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“…In order to avoid the chemical medication of chitosan, noncross-linked CMs were widely fabricated by spray-drying techniques. While monodispersed particle size distribution of CMs was obtained by spray-drying techniques, expensive equipment, and low encapsulation efficiency of protein have been bottlenecks for further commercialization (19)(20)(21).…”

Section: Introductionmentioning

confidence: 99%

Electrospun Chitosan Microspheres for Complete Encapsulation of Anionic Proteins: Controlling Particle Size and Encapsulation Efficiency

et al. 2013

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Abstract. Electrospinning was employed to fabricate chitosan microspheres by a single-step encapsulation of proteins without organic solvents. Chitosan in acetic acid was electrospun toward a grounded sodium carbonate solution at various electric potential and feeding rates. Electrospun microspheres became insoluble and solidified in the sodium carbonate solution by neutralization of chitosan acetate. When the freeze-dried microspheres were examined by scanning electron microscopy, the small particle size was obtained at higher voltages. This is explained by the chitosan droplet size at the electrospinning needle was clearly controllable by the electric potential. The recovery yield of chitosan microspheres was dependent on the concentration of chitosan solution due to the viscosity is the major factor affecting formation of chitosan droplet during curling of the electrospinning jets. For protein encapsulation, fluorescently labeled bovine serum albumin (BSA) was codissolved with chitosan in the solution and electrospun. At higher concentration of sodium carbonate solution and longer solidification time in the solution, the encapsulation efficiency of the protein was confirmed to be significantly high. The high encapsulation efficiency was achievable by instant solidification of microspheres and electrostatic interactions between chitosan and BSA. Release profiles of BSA from the microspheres showed that the protein release was faster in acidic solution due to dissolution of chitosan. Reversed-phase chromatography of the released fractions confirmed that exposure of BSA to acidic solution during the electrospinning did not result in structural changes of the encapsulated protein.

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Section: Introductionmentioning

confidence: 99%

Electrospun Chitosan Microspheres for Complete Encapsulation of Anionic Proteins: Controlling Particle Size and Encapsulation Efficiency

et al. 2013

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“…Similarly, carboxymethyl tamarind kernel powder and chitosan interpolymer complexed film coated tablets have been reported for colon specific delivery of budesonide [8]. Chitosan (CH) carries a net positive charge due to -NH 3 + groups and can be easily cross-linked with other anions, oppositely charged drugs and polymers [9]. CH is easily degraded by lysozyme, by non specific cellulases and enzymes secreted by intestinal bacteria [10].…”

Section: Introductionmentioning

confidence: 99%

Investigations on chitosan-carboxymethyl guar gum complexes interpolymer complexes for colon delivery of fluticasone.

Kumar¹,

Tiwary²,

Kaur³

2010

Int j Drug delivery

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The present study was designed to formulate colon release tablets of fluticasone by employing cross linked chitosan (CH) and carboxymethyl guar gum (CMG) interpolymer complexes (IPC). Matrix tablets were prepared by wet granulation method using IPC as binder and coating agent. The IPC were characterized by Fourier transform infrared spectroscopy (FTIR). The uncoated and coated tablets were tested for their suitability as colon specific drug delivery system by in vitro dissolution studies. The coated tablets were evaluated for their pharmacodynamic performance after oral administration to TNBS induced ulcerative colitic rats. FTIR studies demonstrated that the IPC was formed through an electrostatic interaction between -COO − groups of CMG and -NH 3 + groups of CH. Tablets formulated with 50:50 CH:CMG as binder and coated with the respective ratio of IPC was capable of protecting the drug release in stomach and small intestine and delivering the drug in the colon. Histopathology of the rat colon after oral administration of these IPC film coated tablets revealed significantly greater (p<0.05) reduction in TNBS-induced ulcerative colitis The study confirmed that selective delivery of fluticasone to the colon can be achieved using cross-linked CH and CMG polysaccharides.

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“…34 CS has been well reported to be the most widespread biopolymer having nontoxic, biocompatible, and biodegradable characteristics. 35 In addition, the most common approach for oral Cur delivery is the encapsulation of drug using mucoadhesive polymers such as CS by which the drug is physically protected from enzymatic degradation and intestinal juices. Besides, mucoadhesive in nature CS can enhance the penetration of drugs across mucosal barrier by its interactions with epithelial tight junctions, thereby facilitating transport of drugs across mucosal membrane and improving pharmacological effects.…”

Section: Introductionmentioning

confidence: 99%

Self-assembled nanoparticles based on amphiphilic chitosan derivative and arginine for oral curcumin delivery

Raja

Zeenat

Arif

et al. 2016

IJN

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Curcumin (Cur) is a striking anticancer agent, but its low aqueous solubility, poor absorption, hasty metabolism, and elimination limit its oral bioavailability and consequently hinder its development as a drug. To redress these limitations, amphiphilic chitosan (CS) conjugate with improved mucoadhesion and solubility over a wider pH range was developed by modification with hydrophobic acrylonitrile (AN) and hydrophilic arginine (Arg); the synthesized conjugate (AN–CS–Arg), which was well characterized by Fourier transform infrared and 1 H nuclear magnetic resonance spectroscopy. Results of critical aggregation concentration revealed that the AN–CS–Arg conjugate had low critical aggregation concentration and was prone to form self-assembled nanoparticles (NPs) in aqueous medium. Cur-encapsulated AN–CS–Arg NPs (AN–CS–Arg/Cur NPs) were developed by a simple sonication method and characterized for the physicochemical parameters such as zeta potential, particle size, and drug encapsulation. The results showed that zeta potential of the prepared NPs was 40.1±2.81 mV and the average size was ~218 nm. A considerable improvement in the aqueous solubility of Cur was observed after encapsulation into AN–CS–Arg/Cur NPs. With the increase in Cur concentration, loading efficiency increased but encapsulation efficiency decreased. The in vitro release profile exhibited sustained release pattern from the AN–CS–Arg/Cur NPs in typical biological buffers. The ex vivo mucoadhesion study revealed that AN–CS–Arg/Cur NPs had greater mucoadhesion than the control CS NPs. Compared with free Cur solution, AN–CS–Arg/Cur NPs showed stronger dose-dependent cytotoxicity against HT-29 cells. In addition, it was observed that cell uptake of AN–CS–Arg/Cur NPs was much higher compared with free Cur. Furthermore, the in vivo pharmacokinetic results in rats demonstrated that the AN–CS–Arg/Cur NPs could remarkably improve the oral bioavailability of Cur. Therefore, the developed AN–CS–Arg/Cur NPs might be a promising nano-candidate for oral delivery of Cur.

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Spray-drying of solutions containing chitosan together with polyuronans and characterisation of the microspheres

Cited by 91 publications

References 37 publications

Electrospun Chitosan Microspheres for Complete Encapsulation of Anionic Proteins: Controlling Particle Size and Encapsulation Efficiency

Electrospun Chitosan Microspheres for Complete Encapsulation of Anionic Proteins: Controlling Particle Size and Encapsulation Efficiency

Investigations on chitosan-carboxymethyl guar gum complexes interpolymer complexes for colon delivery of fluticasone.

Self-assembled nanoparticles based on amphiphilic chitosan derivative and arginine for oral curcumin delivery

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