Spray drying of mixed amino acids: The effect of crystallization inhibition and humidity treatment on the particle formation

Lin, Ruohui; Woo, Meng Wai; Wu, Zhangxiong; Liu, Wenjie; Ma, Jisheng; Chen, Xiao; Selomulya, Cordelia

doi:10.1016/j.ces.2017.04.013

Cited by 8 publications

(2 citation statements)

References 31 publications

(43 reference statements)

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“…Spray drying is a liquid atomization technology, an important method for producing a drying powder. It disperses the solution into small droplets through a nozzle, transmits heat and mass using a hot and drying medium, and obtains dry particles through the evaporation of the solvent [103][104][105]. Recently, spray drying has been wellestablished as the preparation strategy for protein nanoparticles [106,107] [99] spray drying method for improving collection efficiency of a typical spray drying method [107].…”

Section: Spray Dryingmentioning

confidence: 99%

Protein nanoparticles directed cancer imaging and therapy

Miao

Yang

et al. 2022

Nano Convergence

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Cancer has been a serious threat to human health. Among drug delivery carriers, protein nanoparticles are unique because of their mild and environmentally friendly preparation methods. They also inherit desired characteristics from natural proteins, such as biocompatibility and biodegradability. Therefore, they have solved some problems inherent to inorganic nanocarriers such as poor biocompatibility. Also, the surface groups and cavity of protein nanoparticles allow for easy surface modification and drug loading. Besides, protein nanoparticles can be combined with inorganic nanoparticles or contrast agents to form multifunctional theranostic platforms. This review introduces representative protein nanoparticles applicable in cancer theranostics, including virus-like particles, albumin nanoparticles, silk protein nanoparticles, and ferritin nanoparticles. It also describes the common methods for preparing them. It then critically analyzes the use of a variety of protein nanoparticles in improved cancer imaging and therapy.

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Section: Spray Dryingmentioning

confidence: 99%

Protein nanoparticles directed cancer imaging and therapy

Miao

Yang

et al. 2022

Nano Convergence

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“…Monodisperse spray drying has a proven track record as a useful technique for studies with moderately volatile solvent systems: changing the drying temperature has been shown to modify particle physical properties for dried milk particles (Rogers et al 2012;Wu et al 2014), amino acid particles (Lin et al 2015), and for silica-lactose composite particles (Liu et al 2012). For solutions with multiple crystallizing solutes, modification of solute ratios may alter the overall morphology and the size of individual crystallites (Lin et al 2017). Choice of solvent has been shown to affect the polymorphic composition and particle morphology for crystalline monodisperse particles formed from solution (Carver and Snyder 2012).…”

Section: Introductionmentioning

confidence: 99%

Experimental investigations of particle formation from propellant and solvent droplets using a monodisperse spray dryer

Ivey

Bhambri

Church

et al. 2018

Aerosol Science and Technology

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Experimental studies of particle formation from solution droplets were conducted using a newly developed monodisperse spray drying process. Solutes beclomethasone dipropionate and caffeine were dissolved in ethanol, pressurized hydrofluoroalkane propellant 134a, and mixtures thereof. Solutions were atomized into monodisperse microdroplets using a custom droplet generator installed in a laboratory scale spray dryer, enabling drying and collection of the resulting monodisperse microparticles. The effects of droplet diameter, solution concentration, solvent composition, and drying rate on the physical properties of the dried particles were evaluated. Particle morphology and size were assessed using ultramicroscopy and image analysis of micrographs. Extent of crystallinity and polymorphism were investigated using Raman spectroscopy. The drying temperature was found to have a large effect on the morphology of amorphous beclomethasone dipropionate particles. Particles dried near room temperature were spheroidal to ellipsoidal with prevalent surface concavities and evidence of shell buckling; increasing the drying temperature for fixed droplet size and composition resulted in a transition to more spherical, smooth-surfaced particle morphologies. Crystalline caffeine microparticles were made up of assemblies of multiple crystallites. The measured length and breadth of these crystallites was found to be correlated with the time available for crystal nucleation and growth as calculated using a particle formation model. The results highlight the abilities and limitations of currently available particle formation models in elucidating the relationships between the size, composition, and evaporation rate of drying solution droplets and the physical properties of the resulting particles. The work demonstrates the suitability of monodisperse spray drying as an experimental technique for investigating the fundamentals of particle formation from solution droplets.

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