Spray drying for processing of nanomaterials

Lindeløv, Jesper Sæderup; Wahlberg, Michael

doi:10.1088/1742-6596/170/1/012027

Cited by 14 publications

(4 citation statements)

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“…We also separately measured the size of particles collected from the collection vessel and particles adhering to the cyclone walls and found that particle size varied depending on the collection location. This is consistent with a previous study by Lindeløv and Wahlberg, which was conducted with a slightly different spray drying configuration and for a different purpose [35].…”

Section: The Size Of the Dry Particles After Spray Dryingsupporting

confidence: 93%

Development of Simvastatin-Loaded Particles Using Spray Drying Method for Ex Tempore Preparation of Cartridges for 2D Printing Technology

Sterle Zorec,

Dreu

2023

Pharmaceutics

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In this work, a spray drying method was developed to produce drug/polymer (simvastatin/polycaprolactone) microparticles that have the potential to be used as a pre-formulation for ex tempore preparation of 2D printing cartridges. An experimental model was designed with the process parameters set to predict the smallest particle size required for successful 2D printing. Three different types of particles (lactose, nanocellulose/lactose, calcium silicate) were produced, and the average size of the dry particles varied depending on the sampling location (cyclone, collection vessel). The encapsulation efficiency of simvastatin was highest with nanocellulose/lactose from the collection vessel. The one-month stability of simvastatin in the particles showed low content, but the addition of ascorbic acid as an antioxidant increased the chemical stability of the drug. Interestingly, the addition of antioxidants decreased the stability of simvastatin in the calcium silicate particles from the collection vessel. Dispersion of the particles in three different propylene glycol and water mixtures (10/90, 50/50, and 90/10% (v/v)), representing a printable ink medium with three different viscosity and surface tension properties, showed that nanocellulose/lactose was the most suitable antiadhesive in terms of dispersed particle size (˂1 µm). After one month of storage, the dispersed particles remained in the same size range without undesirable particle agglomeration.

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Section: The Size Of the Dry Particles After Spray Dryingsupporting

confidence: 93%

Development of Simvastatin-Loaded Particles Using Spray Drying Method for Ex Tempore Preparation of Cartridges for 2D Printing Technology

Sterle Zorec,

Dreu

2023

Pharmaceutics

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“…This means a shorter diffusion time for the nanoparticles to reach the core of the droplet, leading to a more uniform distribution of nanoparticles within the spray‐dried microparticles with less aggregation/coalescence. Furthermore, decreased droplets with a smaller size will form smaller microparticles, which contain less nanoparticles; therefore, the probability of particle aggregation decreased leading to an improved redispersibility of the dried powders and lower RDI values for the dried nanosuspensions prepared at highest atomizing pressure employed in this study at both 70°C and 110°C can be obtained.…”

Section: Resultsmentioning

confidence: 96%

Preparation and Solidification of Redispersible Nanosuspensions

Zhang

Guan

et al. 2014

Journal of Pharmaceutical Sciences

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“…Following completion of production, nanomaterials may be refined through a common process such as spray drying [Lindeløv and Wahlberg 2009]. In the spray-drying process, a mixture of liquid and powder ingredients (slurry) is sprayed within a large sealed tank.…”

Section: Spray Dryermentioning

confidence: 99%