Spray Dried Rugose Lipid Particle Platform for Respiratory Drug Delivery

Wang, Hui; Ordoubadi, Mani; Connaughton, Patrick; Lachacz, Kellisa; Carrigy, Nicholas B.; Tavernini, Scott; Finlay, Warren H.; Lechuga‐Ballesteros, David; Vehring, Reinhard

doi:10.1007/s11095-022-03242-w

Cited by 10 publications

(4 citation statements)

References 69 publications

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“…For such compounds, an organic solvent or a mixture of cosolvents can be selected after a thorough solubility screening. Solubility limitations are of significance only when the API is intended to be dissolved in the feed liquid, as opposed to applications in which one or more of the components are emulsified or dispersed, in which case there should be negligible solubility of the suspended material to avoid instability in the feedstock during manufacturing (Gomez et al, 2021a;Maniyar and Kokare, 2019;Wang H. et al, 2022). A handful of organic solvents have been considered as solvents or cosolvents for feed preparation, with only a limited number of these deemed safe for inhaled product development.…”

Section: The Choice Of the Solvent Systemmentioning

confidence: 99%

Mechanistic Formulation Design of Spray-Dried Powders

Ordoubadi

Wang

Vehring

2023

KONA

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Spray drying is gaining traction in the pharmaceutical industry as one of the processing methods of choice for the manufacture of solid dosage forms intended for pulmonary, oral, and parenteral delivery. This process is particularly advantageous because of its ability to produce engineered particles with improved efficacy and stability by combining active pharmaceutical ingredients or biologics with appropriate excipients. Moreover, due to its high throughput, continuous operation, and ability to produce thermostable solid powders, spray drying can be a manufacturing method of choice in the production of drugs and other formulations, including vaccines, for global distribution. Formulation design based on a mechanistic understanding of the different phenomena that occur during the spray drying of powders is complicated and can therefore make the use of available particle formation models difficult for the practitioner. This review aims to provide step-by-step guidance accompanied by critical background information for the successful formulation design of spray-dried microparticles. These include discussion of the tools needed to estimate the surface concentration of each solute during droplet drying, their times and modes of solidification, and the amount of glass stabilizers and shell formers required to produce stable and dispersible powders.

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Section: The Choice Of the Solvent Systemmentioning

confidence: 99%

Mechanistic Formulation Design of Spray-Dried Powders

Ordoubadi

Wang

Vehring

2023

KONA

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“…Although the use of lactose alone seems to be not as functional as trehalose in encapsulating bioactive compounds, the addition of leucine makes the lactose-leucine combination efficient. Leucine is a hydrophobic amino acid that is often used in spray-dried and respirable formulations to enhance powder flowability and dispersibility (Wang et al, 2022). Moreover, leucine can also influence stability against moisture for spray-dried inhalable powders stored at elevated humidities.…”

Section: Selection Of the Impacting Parametersmentioning

confidence: 99%

Design of respirable sprayed microparticles of encapsulated bacteriophages

Baldelli

Liang

2023

Front. Drug Deliv.

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Antibiotic resistance is exponentially increasing, and the number of deaths caused by bacterial infections is expected to surge. When dealing with the respiratory system, inefficient antibiotics heighten the chance of death from bacterial infection. However, the alternatives to antibiotics are limited. Bacteriophages are a valid option since they can target a specific type of bacterium. Bacteriophages are highly specific and can avoid any side effects when delivered. However, their poor stability makes their use inefficient. Encapsulation is commonly used to protect any bioactive compound for different types of delivery. In the case of respiratory delivery, particle engineering is used to generate stable dry powders to target the nasal or lung areas. This review article provides a guideline for engineering a process of nasal dry powders of encapsulated bacteriophages.

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“…Compared with dietary supplementation and intravenous injection, lipid nanoparticles and liposomes are efficient lipid delivery systems owing to their simple administration mode, controlled drug release, and limited oxidation and degradation [ 5 , 6 ]. For example, lipid nanoparticles have been used for vitamin E delivery to the skin [ 7 ], while liposomes are used as a spray for drug delivery to the respiratory system [ 8 ]. However, the targeting efficiency of lipids is poor.…”

Section: Introductionmentioning

confidence: 99%

Vascular Endothelial Cell-Derived Exosomal Sphingosylphosphorylcholine Attenuates Myocardial Ischemia–Reperfusion Injury through NR4A2-Mediated Mitophagy

Yu,

Li,

Cai

et al. 2024

IJMS

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Cardiomyocyte survival is a critical contributing process of host adaptive responses to cardiovascular diseases (CVD). Cells of the cardiovascular endothelium have recently been reported to promote cardiomyocyte survival through exosome-loading cargos. Sphingosylphosphorylcholine (SPC), an intermediate metabolite of sphingolipids, mediates protection against myocardial infarction (MI). Nevertheless, the mechanism of SPC delivery by vascular endothelial cell (VEC)-derived exosomes (VEC-Exos) remains uncharacterized at the time of this writing. The present study utilized a mice model of ischemia/reperfusion (I/R) to demonstrate that the administration of exosomes via tail vein injection significantly diminished the severity of I/R-induced cardiac damage and prevented apoptosis of cardiomyocytes. Moreover, SPC was here identified as the primary mediator of the observed protective effects of VEC-Exos. In addition, within this investigation, in vitro experiments using cardiomyocytes showed that SPC counteracted myocardial I/R injury by activating the Parkin and nuclear receptor subfamily group A member 2/optineurin (NR4A2/OPTN) pathways, in turn resulting in increased levels of mitophagy within I/R-affected myocardium. The present study highlights the potential therapeutic effects of SPC-rich exosomes secreted by VECs on alleviating I/R-induced apoptosis in cardiomyocytes, thereby providing strong experimental evidence to support the application of SPC as a potential therapeutic target in the prevention and treatment of myocardial infarction.

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Spray Dried Rugose Lipid Particle Platform for Respiratory Drug Delivery

Cited by 10 publications

References 69 publications

Mechanistic Formulation Design of Spray-Dried Powders

Mechanistic Formulation Design of Spray-Dried Powders

Design of respirable sprayed microparticles of encapsulated bacteriophages

Vascular Endothelial Cell-Derived Exosomal Sphingosylphosphorylcholine Attenuates Myocardial Ischemia–Reperfusion Injury through NR4A2-Mediated Mitophagy

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