Spray-Dried Rosuvastatin Nanoparticles for Promoting Hair Growth

Maged, Amr; Mahmoud, Azza A.; Salah, Samia; Abd-Elmonsif, Nehad M; Ghorab, Mahmoud M.

doi:10.1208/s12249-020-01746-5

Cited by 13 publications

(4 citation statements)

References 52 publications

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“…Spray-dried curcumin-loaded proliposomes (SD/P) were prepared using a nano-spray dryer (Buchi ® nano-spray dryer B-90, Büchi Labortechnik, Switzerland) similar to the technique used in previous work with some modifications. 23 For the preparation of SD/P, different components were used. Different ratios of lecithin and cholesterol were tried as follows: 1:1, 2:1 and 3:1 w/w calculated on molar basis with regard to the total lipid content (200 mg).…”

Section: Preparation Of Spray-dried Curcumin-loaded Proliposomes (Sd/p)mentioning

confidence: 99%

Design and Characterization of Spray-Dried Proliposomes for the Pulmonary Delivery of Curcumin

Adel

ElMeligy

Abdelrahim

et al. 2021

IJN

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Purpose The goal was to directly deliver curcumin, a natural polyphenolic anticancer and anti-inflammatory compound, to the lung tissues with minimal systemic exposure through the fabrication of proliposomes, overcoming its poor aqueous solubility and oral bioavailability. Methods Nano-spray drying was employed to prepare proliposomes using hydroxypropyl beta-cyclodextrin as a carrier. Lecithin and cholesterol were used as lipids, stearylamine and Poloxamer 188 were added as positive charge inducer and a surfactant, respectively. Different characterization parameters were evaluated like percentage yield, entrapment efficiency, drug loading, aerodynamic particle size, in vitro release besides morphological examination. Cytotoxicity studies on cell line A549 lung tumor cells as well as in vivo lung pharmacokinetic studies were also carried. Results The optimized formulations showed superior aerosolization properties coupled their enhanced ability to reach deep lung tissues with a high % of fine particle fraction. Cytotoxicity studies using MTT assay demonstrated enhanced growth inhibitory effect on lung tumor cells A549 and significant reduction of proinflammatory cytokines such as tumor necrosis factor-α, interleukin-6 and interleukin-10 compared to the pure drug. Results of lung pharmacokinetic tests confirmed the superiority of proliposomal curcumin over curcumin powder in both, the rate and extent of lung tissue absorption, as well as the mean residence time within the lung tissues. Conclusion The pulmonary delivery of curcumin-loaded proliposomes as dry powder provides a direct approach to lung tissues targeting while avoiding the limitations of the oral route and offering a non-invasive alternative to the parenteral one.

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Section: Preparation Of Spray-dried Curcumin-loaded Proliposomes (Sd/p)mentioning

confidence: 99%

Design and Characterization of Spray-Dried Proliposomes for the Pulmonary Delivery of Curcumin

Adel

ElMeligy

Abdelrahim

et al. 2021

IJN

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“…Rosuvastatin calcium, a renowned statin, has about 20% absolute bioavailability and it effectively lowers lipid levels in the body ( CRESTOR, 2005 ; Maged et al, 2020 ). By inhibiting some of the enzymes required for cell growth, rosuvastatin holds potential in limiting the growth of tumor cells.…”

Section: Introductionmentioning

confidence: 99%

PLGA and PDMS-based in situ forming implants loaded with rosuvastatin and copper-selenium nanoparticles: a promising dual-effect formulation with augmented antimicrobial and cytotoxic activity in breast cancer cells

Maged,

Mabrouk,

Nour El-Din

et al. 2024

Front. Pharmacol.

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Breast cancer is among the most prevalent tumors worldwide. In this study, in-situ forming implants (ISFIs) containing rosuvastatin calcium were prepared using three types of poly (D, L-lactic-co-glycolic acid) (PLGA), namely, PLGA 50/50 with ester terminal and PLGA 75/25 with ester or acid terminal. Additionally, polydimethylsiloxane (PDMS) was added in concentrations of 0, 10, 20, and 30% w/v to accelerate matrix formation. The prepared ISFIs were characterized for their rheological behaviors, rate of matrix formation, and in-vitro drug release. All the prepared formulations revealed a Newtonian flow with a matrix formation rate between 0.017 and 0.059 mm/min. Generally, increasing the concentration of PDMS increased the matrix formation rate. The prepared implants’ release efficiency values ranged between 46.39 and 89.75%. The ISFI containing PLGA 50/50 with 30% PDMS was selected for further testing, as it has the highest matrix formation rate and a promising release efficiency value. Copper-selenium nanoparticles were prepared with two different particle sizes (560 and 383 nm for CS1 and CS2, respectively) and loaded into the selected formulation to enhance its anticancer activity. The unloaded and loaded implants with rosuvastatin and copper-selenium nanoparticles were evaluated for their antibacterial activity, against Gram-positive and negative microorganisms, and anticancer efficacy, against MCF-7 and MDA-MB-231 cell lines. The results confirmed the potency of rosuvastatin calcium against cancer cells and the synergistic effect when loaded with smaller particle sizes of copper-selenium nanoparticles. This formulation holds a considerable potential for efficient breast cancer therapy.

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“…All the previous pros distinguish microfluidic techniques over conventional production methods used to produce nanoparticles. Moreover, in the traditional techniques, the produced nanoparticles possess wide PS distribution, suffer from particles aggregations and loss, and separation using different preparation methods like nanoprecipitation, spray drying, and ultracentrifugation (Salafi et al., 2016 ; Maged et al., 2020 ; Adel et al., 2021 ; Niculescu et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Merits and advances of microfluidics in the pharmaceutical field: design technologies and future prospects

et al. 2022

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Microfluidics is used to manipulate fluid flow in micro-channels to fabricate drug delivery vesicles in a uniform tunable size. Thanks to their designs, microfluidic technology provides an alternative and versatile platform over traditional formulation methods of nanoparticles. Understanding the factors that affect the formulation of nanoparticles can guide the proper selection of microfluidic design and the operating parameters aiming at producing nanoparticles with reproducible properties. This review introduces the microfluidic systems’ continuous flow (single-phase) and segmented flow (multiphase) and their different mixing parameters and mechanisms. Furthermore, microfluidic approaches for efficient production of nanoparticles as surface modification, anti-fouling, and post-microfluidic treatment are summarized. The review sheds light on the used microfluidic systems and operation parameters applied to prepare and fine-tune nanoparticles like lipid, poly(lactic-co-glycolic acid) (PLGA)-based nanoparticles as well as cross-linked nanoparticles. The approaches for scale-up production using microfluidics for clinical or industrial use are also highlighted. Furthermore, the use of microfluidics in preparing novel micro/nanofluidic drug delivery systems is presented. In conclusion, the characteristic vital features of microfluidics offer the ability to develop precise and efficient drug delivery nanoparticles.

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Spray-Dried Rosuvastatin Nanoparticles for Promoting Hair Growth

Cited by 13 publications

References 52 publications

Design and Characterization of Spray-Dried Proliposomes for the Pulmonary Delivery of Curcumin

Design and Characterization of Spray-Dried Proliposomes for the Pulmonary Delivery of Curcumin

PLGA and PDMS-based in situ forming implants loaded with rosuvastatin and copper-selenium nanoparticles: a promising dual-effect formulation with augmented antimicrobial and cytotoxic activity in breast cancer cells

Merits and advances of microfluidics in the pharmaceutical field: design technologies and future prospects

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