Spray-dried nanoparticle-loaded pectin microspheres for dexamethasone nasal delivery

Dukovski, Bisera Jurišić; Mrak, Lea; Winnicka, Katarzyna; Szekalska, Marta; Juretić, Marina; Filipović-Grčić, Jelena; Pepić, Ivan; Lovrić, Jasmina; Hafner, Anita

doi:10.1080/07373937.2018.1545783

Cited by 23 publications

(3 citation statements)

References 36 publications

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“…In this case, the release of active substances is on average 20% higher compared to the first hour for pH 3 and 7.4 for C-X and pH 3 for C-P NCaps. A possible explanation for these results may be the moderate rate of swelling of xanthan gum and pectin [20][21][22][23]. Compared to the release of the active substances alone, thymol was the best, then eugenol and then α-pinene was the worst in terms of release.…”

Section: Discussionmentioning

confidence: 99%

Development of pH-Responsive Biopolymeric Nanocapsule for Antibacterial Essential Oils

Skaličková

Aulichova

Venusová

et al. 2020

IJMS

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It is generally believed that antibacterial essential oils have the potential to become one of the alternatives in preventing diarrheal diseases of monogastric animals. The disadvantage is their low efficiency per oral due to easy degradation during digestion in the stomach. This study compares the efficacy of chitosan, alginate-chitosan, guar gum-chitosan, xanthan gum-chitosan and pectin-chitosan nanocapsules to the synthesis of pH-responsive biopolymeric nanocapsule for Thymus vulgaris, Rosmarinus officinalis and Syzygium aromaticum essential oils. Using spectrophotometric approach and gas chromatography, release kinetics were determined in pH 3, 5.6 and 7.4. The growth rates of S. aureus and E. coli, as well as minimal inhibition concentration of essential oils were studied. The average encapsulation efficiency was 60%, and the loading efficiency was 70%. The size of the nanocapsules ranged from 100 nm to 500 nm. Results showed that chitosan-guar gum and chitosan-pectin nanocapsules released 30% of essential oils (EOs) at pH 3 and 80% at pH 7.4 during 3 h. Similar release kinetics were confirmed for thymol, eugenol and α-pinene. Minimal inhibition concentrations of Thymus vulgaris and Syzygium aromaticum essential oils ranged from 0.025 to 0.5%. Findings of this study suggest that the suitable pH-responsive nanocapsule for release, low toxicity and antibacterial activity is based on chitosan-guar gum structure.

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Section: Discussionmentioning

confidence: 99%

Development of pH-Responsive Biopolymeric Nanocapsule for Antibacterial Essential Oils

Skaličková

Aulichova

Venusová

et al. 2020

IJMS

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“…The latest literature reports show the effectiveness of alginate/pectin microcapsules for encapsulation and controlled release of anthocyanins [ 159 ] or ALG-PC hydrogel films for diabetic wound healing [ 160 ]. Therefore, alginate nanoparticles, loaded with the drug, incorporated within pectin microspheres were studied as a potential nasal delivery system of dexamethasone [ 161 ]. The dry powder showed moderate swelling and mucoadhesive properties in contact with the simulated nasal fluid.…”

Section: Complexed Delivery Systemsmentioning

confidence: 99%

Recent Reports on Polysaccharide-Based Materials for Drug Delivery

Kurczewska

2022

Polymers

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Polysaccharides constitute one of the most important families of biopolymers. Natural polysaccharide-based drug delivery systems are of constant interest to the scientific community due to their unique properties: biocompatibility, non-toxicity, biodegradability, and high availability. These promising biomaterials protect sensitive active agents and provide their controlled release in targeted sites. The application of natural polysaccharides as drug delivery systems is also intensively developed by Polish scientists. The present review focuses on case studies from the last few years authored or co-authored by research centers in Poland. A particular emphasis was placed on the diversity of the formulations in terms of the active substance carried, the drug delivery route, the composition of the material, and its preparation method.

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“…Nasal deposition using human idealized geometry and in vivo pharmacokinetic studies with a rat model were then conducted with the selected formulations. Performance methodologies were chosen based on their frequent use in the literature and biomimetic potential (similar conditions to the nasal cavity) (Wadell et al 2003;Jug et al 2018;Jurišić Dukovski et al 2019;Chen et al 2022;Trenkel and Scherließ 2023). The second aim of this study was to establish IVIVCs of the results obtained, in order to investigate the potential of the methodologies used as predictive tools for nasal powder development.…”

Section: Introductionmentioning

confidence: 99%

Amorphous nasal powder advanced performance: in vitro/ex vivo studies and correlation with in vivo pharmacokinetics

Henriques,

Bicker,

Carona

et al. 2023

J. Pharm. Investig.

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Purpose Amorphous solid dispersions (ASD) for nasal delivery offer the opportunity to increase drug release performance, while using polymers with mucoadhesive properties. The aim of the present study was to apply this solubility enhancement technique to a poorly soluble drug for nasal delivery, while comparing two particle engineering strategies, namely spray dried microparticles and chimeral agglomerates, with the corresponding physical blends with crystalline drug. Methods Formulations of piroxicam were manufactured using varied polymer and particle engineering strategies and evaluated through in vitro drug release and ex vivo permeation studies, as well as nasal deposition and in vivo pharmacokinetic studies. Results ASD with hydroxypropyl methylcellulose (HPMC) showed enhanced drug release and permeation, compared to polyvinylpyrrolidone/vinyl acetate formulations and blends. Nasal deposition of HPMC chimeral agglomerates suggested off-target deposition. In vivo pharmacokinetic studies revealed that spray-dried HPMC-containing microparticles exhibited the highest maximum plasma concentration (Cmax) and the lowest time to attain it (tmax). In vitro release rate and in vivo absorption rate were correlated as well as tmax and in vitro performance. When excluding the formulation with least nasal targeted deposition, in vitro release and ex vivo permeation performance were also correlated with Cmax and area under the drug concentration-time curve (AUC) from 0 to 1 h, with R2 > 0.89. Conclusion ASD for nasal delivery provide fast drug absorption, which depends on the supersaturation ability of the polymer employed. In vitro-in vivo correlations suggested that in vitro release and ex vivo permeation studies are predictive tools regarding nasal absorption.

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Spray-dried nanoparticle-loaded pectin microspheres for dexamethasone nasal delivery

Cited by 23 publications

References 36 publications

Development of pH-Responsive Biopolymeric Nanocapsule for Antibacterial Essential Oils

Development of pH-Responsive Biopolymeric Nanocapsule for Antibacterial Essential Oils

Recent Reports on Polysaccharide-Based Materials for Drug Delivery

Amorphous nasal powder advanced performance: in vitro/ex vivo studies and correlation with in vivo pharmacokinetics

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