2015
DOI: 10.1021/acsnano.5b01139
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Spray-Dried Multiscale Nano-biocomposites Containing Living Cells

Abstract: Three-dimensional encapsulation of cells within nanostructured silica gels or matrices enables applications as diverse as biosensors, microbial fuel cells, artificial organs, and vaccines; it also allows the study of individual cell behaviors. Recent progress has improved the performance and flexibility of cellular encapsulation, yet there remains a need for robust scalable processes. Here, we report a spray-drying process enabling the large-scale production of functional nano-biocomposites (NBCs) containing l… Show more

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Cited by 24 publications
(55 citation statements)
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“…Large scaled artificial organism mineralization treatment can be achieved by spray drying technology . Industrial spray driers are routinely used in pharmaceutical and food industries due to their ease of use, diverse range of liquid precursors, and high product yield and consistency.…”
Section: Approach To Materials Shellsmentioning
confidence: 99%
See 1 more Smart Citation
“…Large scaled artificial organism mineralization treatment can be achieved by spray drying technology . Industrial spray driers are routinely used in pharmaceutical and food industries due to their ease of use, diverse range of liquid precursors, and high product yield and consistency.…”
Section: Approach To Materials Shellsmentioning
confidence: 99%
“…Using silica as an example, solvent evaporation (typically water‐ethanol) concentrates the dissolved silica and surfactant during evaporation‐induced self‐assembly, which causes micelles to form and progressively assemble into 3D silica‐surfactant mesophases. Following this strategy, cell‐directed assembly is developed by replacing standard surfactants with phospholipids, which are integral components of cell membrane with perfect biocompatibility . In cell‐directed assembly, amphiphilic phospholipids serve as the structure‐directing agents to organize hydrophilic silicic acid precursors into highly ordered periodic lipid silica meso‐phases via evaporative processes such as those in spin‐coating.…”
Section: Approach To Materials Shellsmentioning
confidence: 99%
“…Beyond polymer–drug studies, this process recently has been adapted to develop new vaccines 31 and nanobiocomposites. 32 We spray dried phenytoin and nilutamide with representative poly(NIPAm- co -DMA) and HPMCAS (as a commercial excipient control) polymers at 10 and 25 wt % drug loading from methanol. We obtained a distribution of micrometer- and nanosized particles, much smaller than pure crystalline drug (Figure S-25).…”
mentioning
confidence: 99%
“…Sol-gel technology has been significantly improved in the past 20 years. The sol-gel coatings are widely investigated in the area of optics [21], nanobiocomposites [22], biomaterials [23], self-cleaning materials [24] and others [25]. Different sol-gel coatings have been developed to increase the corrosion resistance of metals, although the pure inorganic films have limitations such as micro cracks, residual porosity and thickness limitations [26,27].…”
Section: Introductionmentioning
confidence: 99%