Spray dried mannitol carrier particles with tailored surface properties – The influence of carrier surface roughness and shape

Littringer, Eva Maria; Mescher, Axel; Schroettner, Hartmuth; Achelis, Lydia; Walzel, Peter; Urbanetz, Nora Anne

doi:10.1016/j.ejpb.2012.05.001

Cited by 100 publications

(79 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The use of carrier particles with rougher surfaces was shown to increase [143,158,191,234,[237][238][239][240][241], decrease [21,158,242], or have no significant effect on FPF [243]. Direct proportional relationships were reported between the specific surface area of carrier powders and FPF [244,245], but the reverse trend was also reported [158,246].…”

Section: Surface Propertiesmentioning

confidence: 62%

On the effects of blending, physicochemical properties, and their interactions on the performance of carrier-based dry powders for inhalation — A review

Kaialy

2016

Advances in Colloid and Interface Science

View full text Add to dashboard Cite

Blending drug and carrier powders to produce homogeneous drug-carrier adhesive mixtures is a key step in the production of dry powder inhaler (DPI) formulations. Although the blending conditions can result in different conclusions or probably change the outcome of a study entirely if being selected differently, there is a scarcity of data on the influence of blending processes on the physicochemical properties of bulk powder formulations and the follow-on effects on DPI performance. This paper provides an overview of the interactions between variables related to blending conditions (e.g. blending equipment, time, speed and sequence as well as environmental humidity) and powder physicochemical properties (e.g. size distribution, shape distribution, density, anomeric composition, electrostatic charge, surface, and bulk properties), and their effects on the performance of adhesive mixtures for inhalation in terms of drug content homogeneity, drug-carrier adhesion, and drug aerosolisation behaviour. The relevance of carrier payload, batch size and segregation was also discussed. Challenges and future directions were identified. This review therefore contributes towards a better understanding of the blending process, powder physicochemical properties, and their interlinked effects on the fundamental understanding of adhesive mixtures for inhalation. The knowledge gained is essential to ensure optimum blending and thereby controlled functionality of DPIs.

show abstract

Section: Surface Propertiesmentioning

confidence: 62%

On the effects of blending, physicochemical properties, and their interactions on the performance of carrier-based dry powders for inhalation — A review

Kaialy

2016

Advances in Colloid and Interface Science

View full text Add to dashboard Cite

show abstract

“…Freitas and coworkers [6] discussed dryer design and its relationship with product characteristics. D-mannitol is largely used in pharmaceutical products because of its inertness, low hygroscopicity, good compatibility with the vast majority of excipients and does not present incompatibilities reactions with drugs, proteins and peptides that contains primary amino groups [7]. Furthermore, due to its physical properties spray dried mannitol (SDM) has been extensively studied in the last few years mainly as an alternative to monohydrated a-lactose as a carrier in dried powder inhalers for lung drug administration [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

A multivariate approach applied to quality on particle engineering of spray-dried mannitol

Guimarães

Lanchote

Costa

et al. 2015

Advanced Powder Technology

View full text Add to dashboard Cite

“…The tap and bulk densities increased with increasing concentration of NH 4 HCO 3 . Further, the measured values of CI (>40%) and H (>1.6) indicate an extremely poor flow ability [17,36]; however, commercial mannitol and spray-dried mannitol had similarly poor flow properties. The measured outlet temperature was 65 , and did not change with the concentration of NH 4 HCO 3 in the feed solution.…”

Section: Microparticle Properties and Process Parametersmentioning

confidence: 99%

“…For instance, Podczeck [14] found that small particles improved aerosol performance, while Kaialy et al [5] observed that large particles had such an effect. Further, Maas et al [15] and Kaialy et al [16] found that smooth carriers provided a higher fine particle fraction (FPF) than rough carriers, while Littringer et al [17] showed that rough surface carriers improved the FPF. Such inconsistencies may be attributed to the independent examination of individual properties rather than within the complete system.…”

Section: Introductionmentioning

confidence: 99%

Combined control of morphology and polymorph in spray drying of mannitol for dry powder inhalation

Lyu

Liu

Zhang

et al. 2017

Journal of Crystal Growth

View full text Add to dashboard Cite

The morphology and polymorphism of mannitol particles were controlled during spray drying with the aim of improving the aerosolization properties of inhalable dry powders. The obtained microparticles were characterized using scanning electron microscopy, infrared spectroscopy, differential scanning calorimetry, powder X-ray diffraction and inhaler testing with a next generation impactor. Mannitol particles of varied -mannitol content and surface roughness were prepared via spray drying by manipulating the concentration of NH 4 HCO 3 in the feed solution. The bubbles produced by NH 4 HCO 3 led to the formation of spheroid particles with a rough surface. Further, the fine particle fraction was increased by the rough surface of carriers and the high -mannitol content.Inhalable dry powders with a 29.1 ± 2.4% fine particle fraction were obtained by spray-drying using 5% mannitol (w/v)/2% NH 4 HCO 3 (w/v) as the feed solution, proving that this technique is an effective method to engineer particles for dry powder inhalation.

show abstract

Spray dried mannitol carrier particles with tailored surface properties – The influence of carrier surface roughness and shape

Cited by 100 publications

References 40 publications

On the effects of blending, physicochemical properties, and their interactions on the performance of carrier-based dry powders for inhalation — A review

On the effects of blending, physicochemical properties, and their interactions on the performance of carrier-based dry powders for inhalation — A review

A multivariate approach applied to quality on particle engineering of spray-dried mannitol

Combined control of morphology and polymorph in spray drying of mannitol for dry powder inhalation

Contact Info

Product

Resources

About