Spray bacteriotherapy decreases middle ear fluid in children with secretory otitis media

Abstract

This study shows that spray treatment with S sanguinis may be effective against SOM. The mechanism for the effect remains to be investigated.

Harness the Nature for Computation

“…Secretory otitis media (SOM), persistent fluid in the middle ear cavity, stems from an unknown cause. S Skovbjerg et al [12] used a nasal spray containing alpha-streptococcal bacteria considered to have a protective effect for children prone to middle ear infections, or otitis media. They investigated the clinical, bacteriological, and immunological effects of treatment with pro-biotic bacteria on SOM.…”

Looking after local nasal and sinus mucosa in health, disease and after surgery

“…Probiotic were found to have a beneficial effect in AR by reducing symptom severity and medication use. The use of nasal spray of streptococcus sanignisis produced better resolution of middle ear effusion than placebo with no delitrous effect on nose or nasopharynx [14,15].…”

Oral <i>Lactobacillus plantarum</i> NCIMB 8825 Inhibits Adhesion, Invasion and Metabolism of <i>Neisseria meningitidis</i> Serogroup B and Affords Anti-Inflammatory and Cytotoxic Protection to Nasopharyngeal Epithelial Cells

“…In addition to N. lactamica, other species of commensal lactic acid-producing bacteria have been isolated from the upper respiratory tract (URT) [11][12][13][14][15], including several Lactobacillus (LB) species [11,12,16,17]. Although some LB strains are reported to exhibit direct antimicrobial properties against oral pathogens [11,12], no studies to our knowledge have determined the protective influence of oropharyngeal-derived LB isolates against pathogenic NmB.…”

“…Although some LB strains are reported to exhibit direct antimicrobial properties against oral pathogens [11,12], no studies to our knowledge have determined the protective influence of oropharyngeal-derived LB isolates against pathogenic NmB. Studies on LB isolates from the gut [18] and urogenital tract [19][20][21][22], however, show that they can promote local barrier function and reduce inflammation [18][19][20][21], reduce N. gonnorhoea adhesion [22], E. coli K1 invasion [23] and Group A streptococcal cytotoxicty [24].…”

“…Studies on LB isolates from the gut [18] and urogenital tract [19][20][21][22], however, show that they can promote local barrier function and reduce inflammation [18][19][20][21], reduce N. gonnorhoea adhesion [22], E. coli K1 invasion [23] and Group A streptococcal cytotoxicty [24]. In this study, we have evaluated for the first time the influence of a panel of oropharyngeal-derived LB isolates, with known antimicrobial properties [11,12], and evaluated their potential to afford innate immune protection to nasopharyngeal derived epithelial cells; against the nasopharyngeal coloniser and Gram negative pathogen, NmB.…”