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Green, Antonia; Straube, Benjamin; Kircher, Tilo

doi:10.1007/978-3-540-71147-6_26

Cited by 2 publications

(1 citation statement)

References 36 publications

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“…Both of the above studies suggest that enhanced transcallosal interhemispheric interaction is associated with increased severity of AVH. This conclusion is consistent with findings of neuropsychological studies that have demonstrated reduced REA or even a left ear advantage (LEA) in the DL task in patients with SZ, especially those suffering from AVH (Green et al, 1994 ; Bruder et al, 1995 ; Rossell and Boundy, 2005 ; Hugdahl et al, 2008 ): Green et al ( 2008 ) reported complete absence of a REA in hallucinating patients, indicating an almost perfect LEA. Moreover, Hugdahl et al ( 2008 ) found a negative correlation between the ability to report the RE stimulus and BPRS (Brief Psychiatric Rating Scale) hallucination scores in 87 right-handed SZ patients, using a DL-task of CV-syllables.…”

Section: Altered Structural and Functional Interhemispheric Auditory supporting

confidence: 86%

Interhemispheric auditory connectivity: structure and function related to auditory verbal hallucinations

Steinmann

Leicht

Mulert

2014

Front. Hum. Neurosci.

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Auditory verbal hallucinations (AVH) are one of the most common and most distressing symptoms of schizophrenia. Despite fundamental research, the underlying neurocognitive and neurobiological mechanisms are still a matter of debate. Previous studies suggested that “hearing voices” is associated with a number of factors including local deficits in the left auditory cortex and a disturbed connectivity of frontal and temporoparietal language-related areas. In addition, it is hypothesized that the interhemispheric pathways connecting right and left auditory cortices might be involved in the pathogenesis of AVH. Findings based on Diffusion-Tensor-Imaging (DTI) measurements revealed a remarkable interindividual variability in size and shape of the interhemispheric auditory pathways. Interestingly, schizophrenia patients suffering from AVH exhibited increased fractional anisotropy (FA) in the interhemispheric fibers than non-hallucinating patients. Thus, higher FA-values indicate an increased severity of AVH. Moreover, a dichotic listening (DL) task showed that the interindividual variability in the interhemispheric auditory pathways was reflected in the behavioral outcome: stronger pathways supported a better information transfer and consequently improved speech perception. This detection indicates a specific structure-function relationship, which seems to be interindividually variable. This review focuses on recent findings concerning the structure-function relationship of the interhemispheric pathways in controls, hallucinating and non-hallucinating schizophrenia patients and concludes that changes in the structural and functional connectivity of auditory areas are involved in the pathophysiology of AVH.

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Section: Altered Structural and Functional Interhemispheric Auditory supporting

confidence: 86%

Interhemispheric auditory connectivity: structure and function related to auditory verbal hallucinations

Steinmann

Leicht

Mulert

2014

Front. Hum. Neurosci.

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Funktionelle MRT bei Patienten mit Schizophrenie

2009

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In patients with schizophrenia, numerous mental processes are impaired, which can be related to brain systems using functional imaging methods (e.g. functional magnetic resonance imaging; fMRI). In this review the methodological and conceptual background of fMRI will first be discussed. Secondly, the cerebral networks involved in important symptoms of schizophrenia such as hallucinations, delusions and formal thought disorders will be outlined. Furthermore, the pathways of the central nervous system involved in cognitive dysfunction in patients with schizophrenia will be described also in the dependence on genotype and medicinal status. Functional imaging methods provide psychiatry and psychotherapy with the unique opportunity to correlate mental processes and dysfunctions with neural networks.

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Sprachverständnis — Bildgebung

Cited by 2 publications

References 36 publications

Interhemispheric auditory connectivity: structure and function related to auditory verbal hallucinations

Interhemispheric auditory connectivity: structure and function related to auditory verbal hallucinations

Funktionelle MRT bei Patienten mit Schizophrenie

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