Spotting ‘unproven’ stem Cell Therapies in the Wild

Leask, Freya

doi:10.2144/btn-2019-0143

Cited by 3 publications

(1 citation statement)

References 6 publications

(6 reference statements)

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“…These patients lose objectivity and criticism, and oftentimes become victims of unscrupulous providers. Even those who observe safety issues may not appreciate the importance of the fact that there is a separate categorization of the quality of evidence and strength of recommendations available [22,23] . Failure to recognize the quality of evidence can lead to misguided recommendations.…”

Section: Resultsmentioning

confidence: 99%

Targeting facial aging with nano and regenerative technologies and procedures

Dobke¹,

Hauch²

2020

PAR

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This study reviews information about the most novel ideas and modalities being incorporated into facial and neck cosmetic care. We seek to identify trends and developments within these areas as well as perceptions of plastic surgeons regarding their probable significance, and discussion on how these modalities may impact future practice patterns. It is hypothesized that nano and regenerative technologies are considered the most "hopeful". Emerging invasive and non-invasive modalities utilizing nano and regenerative concepts were reviewed. We intentionally sought to investigate approaches to beautification, including maintenance and reversal of signs of aging, utilizing methods lacking an established level of evidence. This included promising modalities which are currently at the investigational stage. Twelve board-certified plastic surgeons were surveyed regarding the clinical importance of twelve concepts and their expected impact on facial and neck rejuvenation. Scientific and technological creativity in aesthetics is rapidly changing, and the efficacy of innovations and safety margins are improving. Nano and regenerative medicine-based technologies and procedures were ranked most promising for the future of cosmetics. Their potential applications and research were reviewed in the context of surgical and non-surgical modalities in clinical practice. There has been an advent of new approaches to facial and neck aesthetic surgery and tissue care, which is well-beyond just skin care. With this new level of knowledge regarding variability in care responses and indications for procedures on an almost "molecular level", personalized and precise aesthetic surgery and medicine are quickly becoming a reality.

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Section: Resultsmentioning

confidence: 99%

Targeting facial aging with nano and regenerative technologies and procedures

Dobke¹,

Hauch²

2020

PAR

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The Art of Stem Cell-Based Therapy

Burns

2023

Potency Assays for Advanced Stem Cell Therapy Medicinal Products

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Microvascular Tissue as a Platform Technology to Modify the Local Microenvironment and Influence the Healing Cascade

et al. 2020

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Aims: Profiling of microvascular tissue allows identification of components that stimulate wound healing. Here we study those elements for biological effect and establish clinical proof-of-concept using a microvascular tissue graft (mVASC®) in chronic refractory wounds. Methods: mVASC was characterized for tissue fragments and protein composition, evaluated for angiogenic potential in preclinical models, and applied clinically to a series of nonhealing wounds with compromised vascularity of different etiologies. Results: mVASC increased endothelial cell migration in vitro and angiogenesis in mouse ingrowth and hindlimb ischemia models. Clinically, mVASC stimulated wound neovascularization, granulation and epithelialization, and complete and durable healing. Conclusion: Microvascular tissue contains elements relevant to tissue repair and can be clinically applied to enable or accelerate the closure of challenging wounds.

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Spotting ‘unproven’ stem Cell Therapies in the Wild

Abstract: Freya Leask explores how to spot an ‘unproven’ stem cell-based therapy and why producing an effective stem cell-based therapy is so challenging.

Cited by 3 publications

References 6 publications

Targeting facial aging with nano and regenerative technologies and procedures

Targeting facial aging with nano and regenerative technologies and procedures

The Art of Stem Cell-Based Therapy

Microvascular Tissue as a Platform Technology to Modify the Local Microenvironment and Influence the Healing Cascade

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